Aplastic anemia diagnostic study of choice: Difference between revisions

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Revision as of 19:55, 20 August 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Diagnostic Study of Choice

Study of choice

Bone marrow biopsy is the gold standard test for the diagnosis of aplastic anemia

Diagnostic results

The following findings on performing bone marrow biopsy are confirmatory for aplastic anemia:

Hypoplasia with <20% cellularity
Normal maturation of all cell line
Fat cells and stroma in bone marrow space
Residual hematopoietic cells are morphologically normal
Hematopoiesis is not megaloblastic

Sequence of Diagnostic Studies

Investigations must be performed in the following order:

In adults with AA, these tests should be done to detect coexistent disorders, such as paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome, or acute leukemia:

- Flow cytometry for assessment of cell surface CD59 on peripheral blood red blood cells or neutrophils.
- Cytogenetic and molecular testing of bone marrow
In children with AA genetic testing should be performed to find out inherited genetic abnormalities.
Some are Fanconi anemia, dyskeratosis congenita and short telomere syndromes

References

Template:WH Template:WS

@@ Line 10: / Line 10: @@
 ===== Diagnostic results =====
-The following findings  on performing bone marrow biopsy are confirmatory for aplastic anemia:
+The following findings on performing bone marrow biopsy are confirmatory for aplastic anemia:
-* Hypoplasia with <20% cellularity
+* [[Hypoplasia]] with <20% cellularity
-* Normal maturation of all [[cell]] lines
+* Normal maturation of all [[cell]] line
+* Fat cells and [[stroma]] in [[bone marrow]] space
+* Residual [[Hematopoietic cell|hematopoietic cells]] are morphologically normal
+* [[Hematopoiesis]] is not [[Megaloblastic anemia|megaloblastic]]
 ===== Sequence of Diagnostic Studies =====
-The [name of investigation] must be performed when:
+Investigations must be performed in the following order:
-* The patient presented with symptoms/signs 1, 2, and 3 as the first step of diagnosis.
+* '''In adults''' with AA, these tests should be done to detect coexistent disorders, such as paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome, or acute leukemia:
-* A positive [test] is detected in the patient, to confirm the diagnosis.
-OR
+** Flow cytometry for assessment of cell surface CD59 on peripheral blood red blood cells or neutrophils.
+** Cytogenetic and molecular testing of bone marrow
-The various investigations must be performed in the following order:
+* '''In''' '''children''' with AA genetic testing should be performed to find out inherited genetic abnormalities.
-* [Initial investigation]
+* Some are Fanconi anemia, dyskeratosis congenita and short telomere syndromes
-* [2nd investigation]
-=== Name of Diagnostic Criteria ===
-'''It is recommended that you include the criteria in a table. Make sure you always cite the source of the content and whether the table has been adapted from another source.'''
-[Disease name] is primarily diagnosed based on clinical presentation. There are no established criteria for the diagnosis of [disease name].
-OR
-There is no single diagnostic study of choice for [disease name], though [disease name] may be diagnosed based on [name of criteria] established by [...].
-OR
-The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].
-OR
-The diagnosis of [disease name] is based on the [criteria name] criteria, which includes [criterion 1], [criterion 2], and [criterion 3].
-OR
-[Disease name] may be diagnosed at any time if one or more of the following criteria are met:
-* Criteria 1
-* Criteria 2
-* Criteria 3
-OR
-'''IF there are clear, established diagnostic criteria'''
-The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].
-OR
-The diagnosis of [disease name] is based on the [criteria name] criteria, which include [criterion 1], [criterion 2], and [criterion 3].
-OR
-The diagnosis of [disease name] is based on the [definition name] definition, which includes [criterion 1], [criterion 2], and [criterion 3].
-OR
-'''IF there are no established diagnostic criteria'''
-There are no established criteria for the diagnosis of [disease name].
 ==References==