Antistreptococcal antibodies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Antistreptococcal antibodies are antibodies against a series of streptococcal exoantigens. They play a critical role in acute infections of the body surfaces, and certain organs.

Antistreptolysin O titre (AS(L)O titre or AS(L)OT) - titre of (serum) antistreptolysin O antibodies; a blood test used to assist in the diagnosis of a streptococcal infection or indicate a past exposure to streptococci. The ASOT helps direct the antimicrobial treatment and is used to assist in the diagnosis of scarlet fever, rheumatic fever and post infectious glomerulonephritis. The false negatives rate is 20-30%.^[1] If a false negative is suspected then an anti-DNase B titre should be sought. False positives can result from liver disease and tuberculosis.^[1]

Reference Range

ASO/ASL	Up to 200 IU (adults) ^[1] but normal ranges vary from laboratory to laboratory and by age.^[2]
	Up to 150 IU (children)
ADNase	Up to 200 IU

Differential Diagnosis

In alphabetical order. ^[3] ^[4]

Increased Antistreptococcal Antibodies

Acute poststreptococcal glomerulonephritis
Chronic hepatitis
Erysipelas
Hyperlipidemia with obesity
Lipid nephrosis
Membranoproliferative glomerulonephritis
Polyarteritis Nodosa
Rheumatic Carditis
Rheumatic Fever
Scarlet Fever
Streptococcal angina
Streptococcal Infection
Tuberculosis

Decreased Antistreptococcal Antibodies

Antibody Deficiency Syndrome
Exudative enteropathy
Nephrotic Syndrome
Newborns

References

↑ ^1.0 ^1.1 ^1.2 Antistreptococcal antibody titres. gpnotebook. URL: http://www.gpnotebook.co.uk/cache/-1630535637.htm. Accessed on: March 31, 2007.
↑ Danchin M, Carlin J, Devenish W, Nolan T, Carapetis J (2005). "New normal ranges of antistreptolysin O and antideoxyribonuclease B titres for Australian children". J Paediatr Child Health. 41 (11): 583–6. PMID 16398843.
↑ Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
↑ Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X