Anemia with normal reticulocytosis: Difference between revisions

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VisualWikitext

Latest revision as of 17:12, 16 October 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Differentiating Anemia with normal reticulocytosis from Other Diseases

To review the differential diagnosis of anemia, click here.

Disease	Genetics	Clinical manifestation					Lab findings
		History	Symptoms	Signs	Hemolysis	Intrinsic/Extrinsic	Hb concentration	MCV	RDW	Reticulocytosis	Haptoglobin levels	Hepcidin	Iron studies					Specific finding on blood smear
		History	Symptoms	Signs	Hemolysis	Intrinsic/Extrinsic	Hb concentration	MCV	RDW	Reticulocytosis	Haptoglobin levels	Hepcidin	Serum iron	Serum Tfr level	Transferrin or TIBC	Ferritin	Transferrin saturation	Specific finding on blood smear
Iron deficiency anemia^[1]	−	Menorrhagia GI loss GI surgery Pregnancy	Koilonychia Pica	Glossitis Cheilosis Dysphagia	−	−	Hypochromic	Microcytic	↑	Nl or ↓	Nl	Nl	↓	↑	↑	↓	↓↓↓	Central pallor
Lead poisoning^[2]	−	House painted with chipped paint	Burtonian lines Basophilic stippling Wrist drop Foot drop	Wrist drop Foot drop Burtonian lines	−	−	Hypochromic	Microcytic	Nl	Nl or ↓	Nl	Nl	Nl to ↓	Nl	Nl	Nl to ↓	−	RBCs retain aggregates of rRNA Basophilic stippling
Sideroblastic anemia^[3]	Defect in ALA synthase gene Autosomal dominant Autosomal recessive X-linked	Alcohol abuse Isoniazid use Chloramphenicol use Idiopathic	Seborrheic dermatitis Glossy Tongue Tingling	Patient present with symptoms of Vitamin B6, copper deficiency symptoms	−	−	Hypochromic	Microcytic	Nl	Nl or ↓	Nl	Nl	↑	Nl	Nl to ↓	↑	−	Ringed sideroblasts
Disease	Genetics	History	Symptoms	Signs	Hemolysis	Intrinsic/Extrinsic	Hb concentration	MCV	RDW	Reticulocytosis	Haptoglobin levels	Hepcidin	Serum iron	Serum Tfr level	IBC	Ferritin	Transferrin saturation	Specific finding on blood smear
Anemia of chronic disease^[4]	−	Rheumatoid arthritis SLE Neoplasm Chronic kidney disease	Headache Shortness of breath	−	−	−	Hypochromic	Microcytic	Nl	Nl or ↓	Nl	↑	↓	Nl	↓	↑	−	NA
Thalassemia^[5]	α-thalassemia α- globin gene deletions Cis deletions Trans deletions β-thalassemia Point mutation in splice sites and promoter sequences	Associated with parvovirus B19	α-thalassemia Hydrops fetalis β-thalassemia Skeletal deformities Chipmunk facies	Hepatomegaly Splenomegaly	−	−	Hypochromic	Microcytic	Nl	Thalassemia trait: Nl or ↓ Thalassemia Syndromes: ↑	Nl	Nl	Nl to ↑	Nl	Nl	↑	Nl to ↑	Target cells Anisopoikilocytosis
Chronic kidney disease^[6]	−	Pericarditis Encephalopathy Rectal incontinence Decreased libido Restless leg syndrome	Polyuria Hematuria Edema	Hypertension	−	−	Normochromic	Normocytic	↑	Nl or ↑	Nl	↑	↓	−	↓	↑	↓	Nl

References

↑ Camaschella C (May 2015). "Iron-deficiency anemia". N. Engl. J. Med. 372 (19): 1832–43. doi:10.1056/NEJMra1401038. PMID 25946282.
↑ Bain BJ (December 2014). "Lead poisoning". Am. J. Hematol. 89 (12): 1141. doi:10.1002/ajh.23852. PMID 25220013.
↑ Bottomley SS, Fleming MD (August 2014). "Sideroblastic anemia: diagnosis and management". Hematol. Oncol. Clin. North Am. 28 (4): 653–70, v. doi:10.1016/j.hoc.2014.04.008. PMID 25064706.
↑ Roy CN (2010). "Anemia of inflammation". Hematology Am Soc Hematol Educ Program. 2010: 276–80. doi:10.1182/asheducation-2010.1.276. PMID 21239806.
↑ Zainal NZ, Alauddin H, Ahmad S, Hussin NH (December 2014). "α-Thalassemia with Haemoglobin Adana mutation: prenatal diagnosis". Malays J Pathol. 36 (3): 207–11. PMID 25500521.
↑ Drawz P, Rahman M (June 2015). "Chronic kidney disease". Ann. Intern. Med. 162 (11): ITC1–16. doi:10.7326/AITC201506020. PMID 26030647.

[pmid25946282-1] Camaschella C (May 2015). "Iron-deficiency anemia". N. Engl. J. Med. 372 (19): 1832–43. doi:10.1056/NEJMra1401038. PMID 25946282.

[pmid25220013-2] Bain BJ (December 2014). "Lead poisoning". Am. J. Hematol. 89 (12): 1141. doi:10.1002/ajh.23852. PMID 25220013.

[pmid25064706-3] Bottomley SS, Fleming MD (August 2014). "Sideroblastic anemia: diagnosis and management". Hematol. Oncol. Clin. North Am. 28 (4): 653–70, v. doi:10.1016/j.hoc.2014.04.008. PMID 25064706.

[pmid21239806-4] Roy CN (2010). "Anemia of inflammation". Hematology Am Soc Hematol Educ Program. 2010: 276–80. doi:10.1182/asheducation-2010.1.276. PMID 21239806.

[pmid25500521-5] Zainal NZ, Alauddin H, Ahmad S, Hussin NH (December 2014). "α-Thalassemia with Haemoglobin Adana mutation: prenatal diagnosis". Malays J Pathol. 36 (3): 207–11. PMID 25500521.

[pmid26030647-6] Drawz P, Rahman M (June 2015). "Chronic kidney disease". Ann. Intern. Med. 162 (11): ITC1–16. doi:10.7326/AITC201506020. PMID 26030647.

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[6]

@@ Line 63: / Line 63: @@
 | align="left" style="background:#F5F5F5;" |
 * Central [[pallor]]
-|-
-! align="center" style="background:#DCDCDC;" |[[Iron deficiency anemia]] (early phase)<ref name="pmid24972460">{{cite journal |vauthors=De Andrade Cairo RC, Rodrigues Silva L, Carneiro Bustani N, Ferreira Marques CD |title=Iron deficiency anemia in adolescents; a literature review |journal=Nutr Hosp |volume=29 |issue=6 |pages=1240–9 |date=June 2014 |pmid=24972460 |doi=10.3305/nh.2014.29.6.7245 |url=}}</ref>
-| align="center" style="background:#F5F5F5;" | −
-| align="left" style="background:#F5F5F5;" |
-* [[Pica]]
-* [[Glossitis]]
-* [[Angular cheilitis|Cheilosis]]
-| align="left" style="background:#F5F5F5;" |
-* [[Fatigue]]
-* [[Headache]]
-| align="left" style="background:#F5F5F5;" |
-* [[Koilonychia]]
-* Conjunctival [[pallor]]
-* [[Xeroderma|Dry skin]]
-| align="center" style="background:#F5F5F5;" | −
-| align="center" style="background:#F5F5F5;" | −
-| align="center" style="background:#F5F5F5;" | [[Normochromic anemia|Normochromic]]
-| align="center" style="background:#F5F5F5;" | [[Normocytic anemia|Normocytic]]
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | ↓
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | ↓
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | ↓
-| align="center" style="background:#F5F5F5;" | ↓
-| align="left" style="background:#F5F5F5;" |
-* Pencil [[Cell (biology)|cells]]
-* [[Hereditary elliptocytosis|Elliptocytosis]]
-* Hypochromasia
 |-
 ! align="center" style="background:#DCDCDC;" |[[Lead poisoning]]<ref name="pmid25220013">{{cite journal |vauthors=Bain BJ |title=Lead poisoning |journal=Am. J. Hematol. |volume=89 |issue=12 |pages=1141 |date=December 2014 |pmid=25220013 |doi=10.1002/ajh.23852 |url=}}</ref>
@@ Line 239: / Line 208: @@
 * [[Target cell|Target cells]]
 * Anisopoikilocytosis
-|-
-! align="center" style="background:#DCDCDC;" |[[Glucose 6 phosphate dehydrogenase deficiency|G6pd deficiency]]<ref name="pmid24372186">{{cite journal |vauthors=Luzzatto L, Seneca E |title=G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications |journal=Br. J. Haematol. |volume=164 |issue=4 |pages=469–80 |date=February 2014 |pmid=24372186 |pmc=4153881 |doi=10.1111/bjh.12665 |url=}}</ref>
-| align="left" style="background:#F5F5F5;" |
-* Defect in [[Glucose-6-phosphate dehydrogenase|G6PD]] enzyme
-* X-Linked [[recessive]]
-| align="left" style="background:#F5F5F5;" |
-* History of using
-** [[Sulfonamide (medicine)|Sulfa drugs]]
-** [[Antimalarial drug|Antimalarials]]
-** [[Fava bean|Fava Beans]]
-* [[Infection|Infections]]
-| align="left" style="background:#F5F5F5;" |
-* [[Back pain]]
-* [[Hemoglobinuria]]
-| align="left" style="background:#F5F5F5;" |
-* [[Back pain]]
-| align="center" style="background:#F5F5F5;" | +
-| align="center" style="background:#F5F5F5;" |Intrinsic
-| align="center" style="background:#F5F5F5;" |[[Normochromic anemia|Normochromic]]
-| align="center" style="background:#F5F5F5;" |[[Normocytic anemia|Normocytic]]
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↑ but usually causes resolution within 4-7 days
-| align="center" style="background:#F5F5F5;" |↓
-| align="center" style="background:#F5F5F5;" |↓
-| align="center" style="background:#F5F5F5;" |Nl to ↑
-| align="center" style="background:#F5F5F5;" |Nl
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↑
-| align="left" style="background:#F5F5F5;" |
-* [[Red blood cell|RBC]] with [[Heinz bodies]]
-* Bite [[Cell (biology)|cells]]
-* Blister [[Cell (biology)|cells]]
-*
-|-
-! align="center" style="background:#DCDCDC;" |[[Pyruvate kinase deficiency]]<ref name="pmid26087744">{{cite journal |vauthors=Grace RF, Zanella A, Neufeld EJ, Morton DH, Eber S, Yaish H, Glader B |title=Erythrocyte pyruvate kinase deficiency: 2015 status report |journal=Am. J. Hematol. |volume=90 |issue=9 |pages=825–30 |date=September 2015 |pmid=26087744 |pmc=5053227 |doi=10.1002/ajh.24088 |url=}}</ref>
-| align="left" style="background:#F5F5F5;" |
-* [[Mutation]] in the ''[[PKLR]]'' and ''[[PKM2|PKM]]'' gene
-* [[Autosomal recessive]]
-| align="left" style="background:#F5F5F5;" |
-* [[Gallstones]]
-| align="left" style="background:#F5F5F5;" |
-* [[Hydrops fetalis]]
-* [[Neonatal hyperbilirubinemia]]
-* [[Iron overload]]
-* [[Perinatal]] complications
-| align="left" style="background:#F5F5F5;" |
-* Skin [[ulcers]]
-* [[Splenomegaly]]
-| align="center" style="background:#F5F5F5;" | +
-| align="center" style="background:#F5F5F5;" | Intrinsic
-| align="center" style="background:#F5F5F5;" | [[Normochromic anemia|Normochromic]]
-| align="center" style="background:#F5F5F5;" | [[Normocytic anemia|Normocytic]]
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | ↓
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | −
-| align="left" style="background:#F5F5F5;" |
-* Prickle [[cells]]
-* Polychromatophilic [[erythrocytes]]
-|-
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Disease
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Genetics
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Symptoms
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Signs
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hemolysis
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Intrinsic/Extrinsic
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hb concentration
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |MCV
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |RDW
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reticulocytosis
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Haptoglobin levels
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepcidin
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Serum iron
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Serum Tfr level
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |IBC
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Ferritin
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Transferrin saturation
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Specific finding on blood smear
-|-
-! align="center" style="background:#DCDCDC;" |[[Sickle-cell disease|Sickle cell anemia]]<ref name="pmid25431087">{{cite journal |vauthors=Singh PC, Ballas SK |title=Emerging drugs for sickle cell anemia |journal=Expert Opin Emerg Drugs |volume=20 |issue=1 |pages=47–61 |date=March 2015 |pmid=25431087 |doi=10.1517/14728214.2015.985587 |url=}}</ref>
-| align="left" style="background:#F5F5F5;" |
-* Hbs [[point mutation]] causes a single [[Amino acid|amino acid]] replacement in β chain
-| align="left" style="background:#F5F5F5;" |
-* [[High altitude]]
-* Low [[Oxygen]]
-* [[Acidosis]]
-* African-American race
-* [[Parvovirus B19]] infection
-| align="left" style="background:#F5F5F5;" |
-* Painful crisis
-** [[Dactylitis]]
-** [[Priapism]]
-** [[Acute chest syndrome]]
-** [[Avascular necrosis|Avascular Necrosis]]
-** [[Stroke]]
-* [[Autosplenectomy]]
-* [[Salmonella|Salmonella osteomyelitis]]
-| align="left" style="background:#F5F5F5;" |
-* [[Dactylitis]]
-* [[Priapism]]
-| align="center" style="background:#F5F5F5;" | +
-| align="center" style="background:#F5F5F5;" | Intrinsic
-| align="center" style="background:#F5F5F5;" | [[Normochromic anemia|Normochromic]]
-| align="center" style="background:#F5F5F5;" | [[Normocytic anemia|Normocytic]]
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | ↓
-| align="center" style="background:#F5F5F5;" | Nl or moderately ↑
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | Nl or moderately ↑
-| align="center" style="background:#F5F5F5;" | ↓
-| align="center" style="background:#F5F5F5;" | Nl
-| align="left" style="background:#F5F5F5;" |
-* Increased [[erythropoiesis]]
-* [[Howell-Jolly bodies]]
-* [[Anisocytosis]]
-|-
-! align="center" style="background:#DCDCDC;" |HbC disease<ref name="pmid25335812">{{cite journal |vauthors=Lemonne N, Billaud M, Waltz X, Romana M, Hierso R, Etienne-Julan M, Connes P |title=Rheology of red blood cells in patients with HbC disease |journal=Clin. Hemorheol. Microcirc. |volume=61 |issue=4 |pages=571–7 |date=2016 |pmid=25335812 |doi=10.3233/CH-141906 |url=}}</ref>
-| align="left" style="background:#F5F5F5;" |
-* Glutamic acid–to-lysine [[mutation]] in β-globin
-| align="left" style="background:#F5F5F5;" |
-* [[Gallstone]]
-| align="left" style="background:#F5F5F5;" |
-* [[Joint pains]]
-* Increased risk of [[Infection|infections]]
-| align="left" style="background:#F5F5F5;" |
-* [[Splenomegaly]]
-* [[Gallstone disease|Cholelithiasis]]
-* [[Avascular necrosis|Avascular necrosis of the femoral head]]
-| align="center" style="background:#F5F5F5;" | +
-| align="center" style="background:#F5F5F5;" | Intrinsic
-| align="center" style="background:#F5F5F5;" | [[Normochromic anemia|Normochromic]]
-| align="center" style="background:#F5F5F5;" | [[Normocytic anemia|Normocytic]]
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | ↓
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | ↓
-| align="center" style="background:#F5F5F5;" | −
-| align="left" style="background:#F5F5F5;" |
-* Hemoglobin crystals inside [[RBCs]]
-* [[Target cell|Target cells]]
-|-
-! align="center" style="background:#DCDCDC;" |[[Paroxysmal nocturnal hemoglobinuria]]<ref name="pmid1402472">{{cite journal |vauthors=Bunyaratvej A, Butthep P |title=Cytometric analysis of paroxysmal nocturnal hemoglobinuria erythrocytes |journal=J Med Assoc Thai |volume=75 Suppl 1 |issue= |pages=237–42 |date=January 1992 |pmid=1402472 |doi= |url=}}</ref><ref name="pmid25553278">{{cite journal |vauthors=Kahng J, Kim Y, Kim JO, Koh K, Lee JW, Han K |title=A novel marker for screening paroxysmal nocturnal hemoglobinuria using routine complete blood count and cell population data |journal=Ann Lab Med |volume=35 |issue=1 |pages=35–40 |date=January 2015 |pmid=25553278 |pmc=4272963 |doi=10.3343/alm.2015.35.1.35 |url=}}</ref>
-| align="left" style="background:#F5F5F5;" |
-* [[PIGA]] gene mutations
-* Impaired  synthesis of [[GPI anchor]] for [[decay-accelerating  factor]]
-| align="left" style="background:#F5F5F5;" |
-* Associated with [[aplastic anemia]]
-* [[Thrombosis]]
-| align="left" style="background:#F5F5F5;" |
-* [[Fatigue]]
-* [[Chest pain]]
-* [[Dyspnea]] on exertion
-* [[Headache]]
-| align="left" style="background:#F5F5F5;" |
-* [[Hemolysis|Chronic hemolysis]]
-* [[Hepatomegaly]]
-* [[Ascites]]
-* [[Papilledema]]
-* Skin nodules
-| align="center" style="background:#F5F5F5;" | +
-| align="center" style="background:#F5F5F5;" | Intrinsic
-| align="center" style="background:#F5F5F5;" | [[Normochromic anemia|Normochromic]]
-| align="center" style="background:#F5F5F5;" | [[Normocytic anemia|Normocytic]]
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | ↓
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | ↓
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | ↓
-| align="center" style="background:#F5F5F5;" | −
-| align="center" style="background:#F5F5F5;" | NA
-|-
-! align="center" style="background:#DCDCDC;" |[[Hereditary spherocytosis]]<ref name="pmid23664421">{{cite journal |vauthors=Da Costa L, Galimand J, Fenneteau O, Mohandas N |title=Hereditary spherocytosis, elliptocytosis, and other red cell membrane disorders |journal=Blood Rev. |volume=27 |issue=4 |pages=167–78 |date=July 2013 |pmid=23664421 |doi=10.1016/j.blre.2013.04.003 |url=}}</ref>
-| align="left" style="background:#F5F5F5;" |
-* [[Mutations]] in [[Ankyrin]], [[Band 3]], [[Protein 4.2]], and [[spectrin]]
-| align="left" style="background:#F5F5F5;" |
-* Associated with [[parvovirus B19]]
-* [[Cholelithiasis]]
-* Megaloblastic crisis
-| align="left" style="background:#F5F5F5;" |
-* [[Aplastic crisis]]
-| align="left" style="background:#F5F5F5;" |
-* [[Splenomegaly]]
-| align="center" style="background:#F5F5F5;" | +
-| align="center" style="background:#F5F5F5;" | Intrinsic
-| align="center" style="background:#F5F5F5;" | [[Normochromic anemia|Normochromic]]
-| align="center" style="background:#F5F5F5;" | [[Normocytic anemia|Normocytic]]
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | ↓
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | ↓
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | −
-| align="left" style="background:#F5F5F5;" |
-* Small, round [[Red blood cell|RBC]]s with less surface area and no central pallor
-|-
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Disease
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Genetics
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Symptoms
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Signs
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hemolysis
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Intrinsic/Extrinsic
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hb concentration
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |MCV
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |RDW
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reticulocytosis
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Haptoglobin levels
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepcidin
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Serum iron
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Serum Tfr level
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |IBC
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Ferritin
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Transferrin saturation
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Specific finding on blood smear
-|-
-! align="center" style="background:#DCDCDC;" |[[Microangiopathic hemolytic anemia]]<ref name="pmid26251142">{{cite journal |vauthors=Morishita E |title=[Diagnosis and treatment of microangiopathic hemolytic anemia] |language=Japanese |journal=Rinsho Ketsueki |volume=56 |issue=7 |pages=795–806 |date=July 2015 |pmid=26251142 |doi=10.11406/rinketsu.56.795 |url=}}</ref><ref name="pmid23390027">{{cite journal |vauthors=George JN, Charania RS |title=Evaluation of patients with microangiopathic hemolytic anemia and thrombocytopenia |journal=Semin. Thromb. Hemost. |volume=39 |issue=2 |pages=153–60 |date=March 2013 |pmid=23390027 |doi=10.1055/s-0032-1333538 |url=}}</ref>
-| align="center" style="background:#F5F5F5;" | −
-| align="left" style="background:#F5F5F5;" | Associated with
-* [[Disseminated intravascular coagulation|DIC]]
-* [[TTP]]
-* [[Hemolytic-uremic syndrome|HUS]]
-* [[SLE]]
-* [[HELLP syndrome]]
-* [[Hypertensive crisis|Hypertensive emergency]]
-| align="left" style="background:#F5F5F5;" |
-* [[Purpura]]
-* [[Confusion]]
-* [[Aphasia]]
-* [[Diplopia]]
-| align="left" style="background:#F5F5F5;" |
-* [[Paresthesia|Numbness]] of an arm or hand
-* [[Jaundice]]
-* [[Pallor|Pale conjunctiva]]
-| align="center" style="background:#F5F5F5;" | +
-| align="center" style="background:#F5F5F5;" | Extrinsic
-| align="center" style="background:#F5F5F5;" | [[Normochromic anemia|Normochromic]]
-| align="center" style="background:#F5F5F5;" | [[Normocytic anemia|Normocytic]]
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | ↓
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | ↓
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | −
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | −
-| align="left" style="background:#F5F5F5;" |
-* Helmet cells
-|-
-! align="center" style="background:#DCDCDC;" |Macroangiopathic hemolytic anemia<ref name="pmid5108522">{{cite journal |vauthors=Westphal RG, Azen EA |title=Macroangiopathic hemolytic anemia due to congenital cardiovascular anomalies |journal=JAMA |volume=216 |issue=9 |pages=1477–8 |date=May 1971 |pmid=5108522 |doi= |url=}}</ref>
-| align="left" style="background:#F5F5F5;" |
-* [[Autoimmunity|Autoimmune]]
-| align="left" style="background:#F5F5F5;" | Associated with
-* [[Artificial heart valve|Prosthetic heart valves]]
-* [[Aortic stenosis]]
-| align="left" style="background:#F5F5F5;" |
-* [[Pallor]]
-* [[Fatigue]]
-| align="left" style="background:#F5F5F5;" |
-* Signs of [[anemia]]
-* Complications of [[hemolysis]]
-* Decreased vascular volume
-| align="center" style="background:#F5F5F5;" | +
-| align="center" style="background:#F5F5F5;" | Extrinsic
-| align="center" style="background:#F5F5F5;" | [[Normochromic anemia|Normochromic]]
-| align="center" style="background:#F5F5F5;" | [[Normocytic anemia|Normocytic]]
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | ↓
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | ↓
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | −
-| align="center" style="background:#F5F5F5;" | −
-| align="center" style="background:#F5F5F5;" | −
-| align="left" style="background:#F5F5F5;" |
-* [[Spherocytosis|Spherocytes]] or [[Red blood cell|schistocytes]]
-|-
-! align="center" style="background:#DCDCDC;" |[[Autoimmune  hemolytic anemia]]<ref name="pmid26447931">{{cite journal |vauthors=Hill QA |title=Autoimmune hemolytic anemia |journal=Hematology |volume=20 |issue=9 |pages=553–4 |date=October 2015 |pmid=26447931 |doi=10.1179/1024533215Z.000000000401 |url=}}</ref>
-| align="center" style="background:#F5F5F5;" | −
-| align="left" style="background:#F5F5F5;" | Associated with:
-* [[SLE]]
-* [[Chronic lymphocytic leukemia|CLL]]
-* [[Mycoplasma pneumonia]]
-| align="left" style="background:#F5F5F5;" |
-* Painful blue fingers and toes on exposure to cold temperature
-* [[Chest pain]]
-* [[Rigor|Chills]]
-* [[Dizziness]]
-* [[Tachycardia]]
-* [[Headache]]
-* [[Fatigue]]
-| align="left" style="background:#F5F5F5;" |
-* Painful, blue fingers and toes with cold weather
-| align="center" style="background:#F5F5F5;" | +
-| align="center" style="background:#F5F5F5;" | Extrinsic
-| align="center" style="background:#F5F5F5;" | [[Normochromic anemia|Normochromic]]
-| align="center" style="background:#F5F5F5;" | [[Normocytic anemia|Normocytic]]
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | ↓
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | ↓
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | −
-| align="center" style="background:#F5F5F5;" | −
-| align="center" style="background:#F5F5F5;" | −
-| align="left" style="background:#F5F5F5;" |
-* [[Red blood cell|RBC]] agglutination
-|-
-! align="center" style="background:#DCDCDC;" |[[Aplastic anemia]]<ref name="pmid24424170">{{cite journal |vauthors=Dolberg OJ, Levy Y |title=Idiopathic aplastic anemia: diagnosis and classification |journal=Autoimmun Rev |volume=13 |issue=4-5 |pages=569–73 |date=2014 |pmid=24424170 |doi=10.1016/j.autrev.2014.01.014 |url=}}</ref>
-| align="left" style="background:#F5F5F5;" |
-* Constitutive expression of Tbet
-* [[Mutation|Mutations]] in the [[perforin]] gene
-* Mutations in ''SAP'' gene
-| align="left" style="background:#F5F5F5;" |
-* Exposure to [[Radiation]]
-* Drugs like [[Benzene]], [[chloramphenicol]], [[Alkylating agent|alkylating agents]]
-* Viral infections like [[EBV]], [[HIV]], [[Hepatitis]]
-* [[Fanconi anemia]]
-* Idiopathic like [[Immune]] mediated, primary stem cell defect
-| align="left" style="background:#F5F5F5;" |
-* Symptoms based on underlying condition
-| align="left" style="background:#F5F5F5;" |
-* Short stature
-* [[Cafe-au-lait spots]]
-* Thumb defects
-* [[Radius (bone)|Radial]] defects
-| align="center" style="background:#F5F5F5;" | −
-| align="center" style="background:#F5F5F5;" |−
-| align="center" style="background:#F5F5F5;" |[[Normochromic anemia|Normochromic]]
-| align="center" style="background:#F5F5F5;" |[[Normocytic anemia|Normocytic]]
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↓
-| align="center" style="background:#F5F5F5;" |Nl
-| align="center" style="background:#F5F5F5;" |Nl
-| align="center" style="background:#F5F5F5;" |↓
-| align="center" style="background:#F5F5F5;" |↓
-| align="center" style="background:#F5F5F5;" |Nl
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↓
-| align="left" style="background:#F5F5F5;" |
-* [[Pancytopenia]]
-* Fatty [[Infiltration (medical)|infiltration]]
-|-
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Disease
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Genetics
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Symptoms
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Signs
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hemolysis
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Intrinsic/Extrinsic
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hb concentration
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |MCV
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |RDW
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reticulocytosis
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Haptoglobin levels
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepcidin
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Serum iron
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Serum Tfr level
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |IBC
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Ferritin
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Transferrin saturation
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Specific finding on blood smear
-|-
-! align="center" style="background:#DCDCDC;" |[[Folate deficiency]]<ref name="pmid25663227">{{cite journal |vauthors=Koike H, Takahashi M, Ohyama K, Hashimoto R, Kawagashira Y, Iijima M, Katsuno M, Doi H, Tanaka F, Sobue G |title=Clinicopathologic features of folate-deficiency neuropathy |journal=Neurology |volume=84 |issue=10 |pages=1026–33 |date=March 2015 |pmid=25663227 |doi=10.1212/WNL.0000000000001343 |url=}}</ref>
-| align="left" style="background:#F5F5F5;" |
-* Impaired [[DNA]] synthesis
-| align="left" style="background:#F5F5F5;" |
-* [[Long-term effects of alcohol|Alcohol consumption]]
-* History of using drugs like [[methotrexate]], [[trimethoprim]], and [[phenytoin]]
-* Low socioeconomic groups with poor nutrition
-* Older people
-* [[Pregnancy|Pregnant]] and [[lactating]] women
-| align="left" style="background:#F5F5F5;" |
-* No neurological symptoms vs [[Vitamin B12 deficiency|B12 deficiency]]
-* [[Odinophagia|Odynophagia]]
-* [[Stomatitis|Angular stomatitis]]
-| align="left" style="background:#F5F5F5;" |
-* [[Glossitis]]
-* Signs of [[Congestive heart failure|heart failure]]
-* [[Anencephaly]] and [[spina bifida]]
-| align="center" style="background:#F5F5F5;" |−
-| align="center" style="background:#F5F5F5;" |−
-| align="center" style="background:#F5F5F5;" |Anisochromic
-| align="center" style="background:#F5F5F5;" |[[Macrocytic anemia|Macrocytic]]
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↓
-| align="center" style="background:#F5F5F5;" |Nl
-| align="center" style="background:#F5F5F5;" |Nl
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↓
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↑
-| align="left" style="background:#F5F5F5;" |
-* [[Macrocytosis|RBC macrocytosis]]
-* [[Neutrophil|Hypersegmented neutrophils]]
-* [[Pancytopenia]] in severe cases
-*
-|-
-! align="center" style="background:#DCDCDC;" |[[Vitamin B12 deficiency]]<ref name="pmid25189324">{{cite journal |vauthors=Hunt A, Harrington D, Robinson S |title=Vitamin B12 deficiency |journal=BMJ |volume=349 |issue= |pages=g5226 |date=September 2014 |pmid=25189324 |doi= |url=}}</ref>
-| align="left" style="background:#F5F5F5;" |
-* Impaired [[DNA synthesis]]
-| align="left" style="background:#F5F5F5;" |
-* [[Pernicious anemia]]
-* [[Crohn's disease]]
-* [[Gastrectomy]]
-* [[Vegan|Veganism]]
-* [[Diphyllobothrium|Diphyllobothrium latum]] infection
-| align="left" style="background:#F5F5F5;" |
-* [[Psychosis]]
-* [[Insomnia]]
-* [[Depression]]
-* Cognitive slowing
-* [[Restless leg syndrome]]
-| align="left" style="background:#F5F5F5;" |
-* Neurological deficit
-* [[Myelopathy]]
-* [[Memory loss]] with reduced attention span
-* [[Nystagmus]]
-* Positive [[Romberg test|romberg sign]]
-* Positive [[Lhermitte's sign]]
-| align="center" style="background:#F5F5F5;" |−
-| align="center" style="background:#F5F5F5;" |−
-| align="center" style="background:#F5F5F5;" |Anisochromic
-| align="center" style="background:#F5F5F5;" |[[Macrocytic anemia|Macrocytic]]
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↓
-| align="center" style="background:#F5F5F5;" |Nl
-| align="center" style="background:#F5F5F5;" |Nl
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↓
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↑
-| align="left" style="background:#F5F5F5;" |
-* [[Senile]] [[neutrophil]]
-* [[Anisocytosis]]
-* [[Ovalocytosis|Ovalocytes]]
-|-
-! align="center" style="background:#DCDCDC;" |[[Orotic aciduria]]<ref name="pmid25757096">{{cite journal |vauthors=Grohmann K, Lauffer H, Lauenstein P, Hoffmann GF, Seidlitz G |title=Hereditary orotic aciduria with epilepsy and without megaloblastic anemia |journal=Neuropediatrics |volume=46 |issue=2 |pages=123–5 |date=April 2015 |pmid=25757096 |doi=10.1055/s-0035-1547341 |url=}}</ref>
-| align="left" style="background:#F5F5F5;" |
-* [[Autosomal recessive]]
-* Deficiency of enzyme [[Uridine monophosphate synthetase|UMPS]]
-| align="left" style="background:#F5F5F5;" |
-* Episodic [[Nausea and vomiting|vomiting]]
-* [[Rhabdomyolysis]]
-| align="left" style="background:#F5F5F5;" |
-* [[Coma]]
-* [[Gastrointestinal tract|Gastrointestinal]] manifestation
-| align="left" style="background:#F5F5F5;" |
-* Neurological manifestation
-| align="center" style="background:#F5F5F5;" |−
-| align="center" style="background:#F5F5F5;" |−
-| align="center" style="background:#F5F5F5;" |Anisochromic
-| align="center" style="background:#F5F5F5;" |[[Macrocytic anemia|Macrocytic]]
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↓
-| align="center" style="background:#F5F5F5;" |Nl
-| align="center" style="background:#F5F5F5;" |Nl
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↓
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |NA
-|-
-! align="center" style="background:#DCDCDC;" |[[Fanconi anemia]]<ref name="pmid25455269">{{cite journal |vauthors=Alter BP |title=Fanconi anemia and the development of leukemia |journal=Best Pract Res Clin Haematol |volume=27 |issue=3-4 |pages=214–21 |date=2014 |pmid=25455269 |pmc=4254647 |doi=10.1016/j.beha.2014.10.002 |url=}}</ref>
-| align="left" style="background:#F5F5F5;" |
-* [[Autosomal recessive]]
-* [[X-linked recessive]]
-| align="left" style="background:#F5F5F5;" |
-* History of [[anemia]] at age 16
-| align="left" style="background:#F5F5F5;" |
-* [[Hypopigmentation]]
-* [[Café au lait spot|Cafe-au-lait patches]]
-* Radial ray anomaly
-| align="left" style="background:#F5F5F5;" |
-* Significant for bilateral short thumbs
-| align="center" style="background:#F5F5F5;" |−
-| align="center" style="background:#F5F5F5;" |−
-| align="center" style="background:#F5F5F5;" |Anisochromic
-| align="center" style="background:#F5F5F5;" |[[Macrocytic anemia|Macrocytic]]
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↓
-| align="center" style="background:#F5F5F5;" |Nl
-| align="center" style="background:#F5F5F5;" |Nl
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↓
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↑
-| align="left" style="background:#F5F5F5;" |
-* Nl appearing [[White blood cells|WBC]], [[Red blood cell|RBC]] and [[Platelet|Platelets]]
-* But the number is greatly reduced
-|-
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Disease
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Genetics
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Symptoms
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Signs
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hemolysis
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Intrinsic/Extrinsic
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hb concentration
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |MCV
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |RDW
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reticulocytosis
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Haptoglobin levels
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepcidin
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Serum iron
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Serum Tfr level
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |IBC
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Ferritin
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Transferrin saturation
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Specific finding on blood smear
-|-
-! align="center" style="background:#DCDCDC;" |[[Diamond-Blackfan anemia]]<ref name="pmid24665981">{{cite journal |vauthors=Vlachos A, Blanc L, Lipton JM |title=Diamond Blackfan anemia: a model for the translational approach to understanding human disease |journal=Expert Rev Hematol |volume=7 |issue=3 |pages=359–72 |date=June 2014 |pmid=24665981 |doi=10.1586/17474086.2014.897923 |url=}}</ref>
-| align="left" style="background:#F5F5F5;" |Mutations in:
-* ''RPL5''
-* ''RPL11''
-* ''RPL35A''
-* ''RPS7''
-* ''RPS10''
-* ''RPS17''
-* ''RPS19''
-* ''RPS24''
-* ''RPS26''
-| align="left" style="background:#F5F5F5;" |
-* Associated with [[myelodysplastic syndrome]]
-* Increased risk of [[AML]]
-| align="left" style="background:#F5F5F5;" |
-* [[Pale skin]]
-* Sleepiness
-* [[Murmur|Heart murmurs]]
-| align="left" style="background:#F5F5F5;" |
-* Triphalangeal  thumbs
-* [[Short stature]]
-* [[Microcephaly]]
-* [[Hypertelorism]]
-* [[Ptosis]]
-* [[Micrognathia]]
-| align="center" style="background:#F5F5F5;" |−
-| align="center" style="background:#F5F5F5;" |−
-| align="center" style="background:#F5F5F5;" |Anisochromic
-| align="center" style="background:#F5F5F5;" |[[Macrocytic anemia|Macrocytic]]
-| align="center" style="background:#F5F5F5;" |Nl
-| align="center" style="background:#F5F5F5;" |↓
-| align="center" style="background:#F5F5F5;" |Nl
-| align="center" style="background:#F5F5F5;" |Nl
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↓
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |NA
-|-
-! align="center" style="background:#DCDCDC;" |[[Infection|Infections]]<ref name="pmid23324217">{{cite journal |vauthors=Bustinduy AL, Parraga IM, Thomas CL, Mungai PL, Mutuku F, Muchiri EM, Kitron U, King CH |title=Impact of polyparasitic infections on anemia and undernutrition among Kenyan children living in a Schistosoma haematobium-endemic area |journal=Am. J. Trop. Med. Hyg. |volume=88 |issue=3 |pages=433–40 |date=March 2013 |pmid=23324217 |pmc=3592521 |doi=10.4269/ajtmh.12-0552 |url=}}</ref>
-| align="center" style="background:#F5F5F5;" | −
-| align="left" style="background:#F5F5F5;" | Associated with
-* [[Malaria]]
-* [[Babesia]]
-| align="left" style="background:#F5F5F5;" |
-* [[Fever]]
-| align="left" style="background:#F5F5F5;" |
-* [[Fever]]
-* Signs of [[shock]]
-* [[Headache]]
-| align="center" style="background:#F5F5F5;" | +
-| align="center" style="background:#F5F5F5;" | Extrinsic
-| align="center" style="background:#F5F5F5;" | [[Normochromic anemia|Normochromic]]
-| align="center" style="background:#F5F5F5;" | [[Normocytic anemia|Normocytic]]
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | ↑
-| align="center" style="background:#F5F5F5;" | ↓
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | Nl
-| align="center" style="background:#F5F5F5;" | −
-| align="center" style="background:#F5F5F5;" | −
-| align="center" style="background:#F5F5F5;" | −
-| align="left" style="background:#F5F5F5;" |
-* [[Trophozoite]]
-* Maltese crosses
 |-
 ! align="center" style="background:#DCDCDC;" |[[Chronic renal failure|Chronic kidney disease]]<ref name="pmid26030647">{{cite journal |vauthors=Drawz P, Rahman M |title=Chronic kidney disease |journal=Ann. Intern. Med. |volume=162 |issue=11 |pages=ITC1–16 |date=June 2015 |pmid=26030647 |doi=10.7326/AITC201506020 |url=}}</ref>
@@ Line 863: / Line 228: @@
 | align="center" style="background:#F5F5F5;" |[[Normocytic anemia|Normocytic]]
 | align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |Nl/↑
+| align="center" style="background:#F5F5F5;" |Nl or ↑
 | align="center" style="background:#F5F5F5;" |Nl
 | align="center" style="background:#F5F5F5;" |↑
@@ Line 872: / Line 237: @@
 | align="center" style="background:#F5F5F5;" |↓
 | align="center" style="background:#F5F5F5;" |Nl
-|-
-! align="center" style="background:#DCDCDC;" |[[Hepato-biliary diseases|Liver disease]]<ref name="pmid23953338">{{cite journal |vauthors=Marks PW |title=Hematologic manifestations of liver disease |journal=Semin. Hematol. |volume=50 |issue=3 |pages=216–21 |date=July 2013 |pmid=23953338 |doi=10.1053/j.seminhematol.2013.06.003 |url=}}</ref>
-| align="center" style="background:#F5F5F5;" |−
-| align="left" style="background:#F5F5F5;" |
-* [[Hepatitis]]
-* Binge drinking
-* Gall bladder disease
-| align="left" style="background:#F5F5F5;" |
-* [[Jaundice]]
-* [[Abdominal pain]]
-* [[Itchy skin]]
-| align="left" style="background:#F5F5F5;" |
-* [[Ascites]]
-* Right upper quadrant pain
-* [[Hepatomegaly]]
-* [[Edema|Swelling]] in the legs
-* [[Ankle swelling]]
-| align="center" style="background:#F5F5F5;" |−
-| align="center" style="background:#F5F5F5;" |−
-| align="center" style="background:#F5F5F5;" |Anisochromic
-| align="center" style="background:#F5F5F5;" |[[Macrocytic anemia|Macrocytic]]
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |Nl
-| align="center" style="background:#F5F5F5;" |Nl
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↓
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↑
-| align="left" style="background:#F5F5F5;" |
-* [[Macrocyte|Round macrocytes]]
-* [[Macrocyte|Target macrocytes]]
-|-
-! align="center" style="background:#DCDCDC;" |[[Alcoholism]]<ref name="pmid24588059">{{cite journal |vauthors=Yokoyama A, Yokoyama T, Brooks PJ, Mizukami T, Matsui T, Kimura M, Matsushita S, Higuchi S, Maruyama K |title=Macrocytosis, macrocytic anemia, and genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 in Japanese alcoholic men |journal=Alcohol. Clin. Exp. Res. |volume=38 |issue=5 |pages=1237–46 |date=May 2014 |pmid=24588059 |doi=10.1111/acer.12372 |url=}}</ref>
-| align="center" style="background:#F5F5F5;" |−
-| align="left" style="background:#F5F5F5;" |
-* History of increased [[Effects of alcohol on the body|alcohol intake]]
-* [[Folic acid deficiency]]
-| align="left" style="background:#F5F5F5;" |
-* [[Memory impairment]]
-* [[Nausea]]
-* [[Sweating]]
-| align="left" style="background:#F5F5F5;" |
-* Truncal [[obesity]]
-* [[Asterixis]]
-* [[Encephalopathy]]
-* [[Spider angiomas]]
-* [[Hematemesis]]
-* [[Gynecomastia]]
-| align="center" style="background:#F5F5F5;" |−
-| align="center" style="background:#F5F5F5;" |−
-| align="center" style="background:#F5F5F5;" |Anisochromic
-| align="center" style="background:#F5F5F5;" |[[Macrocytic anemia|Macrocytic]]
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |Nl
-| align="center" style="background:#F5F5F5;" |Nl
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↓
-| align="center" style="background:#F5F5F5;" |↑
-| align="center" style="background:#F5F5F5;" |↑
-| align="left" style="background:#F5F5F5;" |
-* [[Macrocyte|Oval macrocytes]]
-* [[Neutrophil|Hypersegmented neutrophils]]
-|-
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Disease
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Genetics
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Symptoms
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Signs
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hemolysis
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Intrinsic/Extrinsic
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hb concentration
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |MCV
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |RDW
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reticulocytosis
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Haptoglobin levels
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hepcidin
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Serum iron
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Serum Tfr level
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |IBC
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Ferritin
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Transferrin saturation
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Specific finding on blood smear
 |}
 ==References==
 {{Reflist|2}}

Anemia with normal reticulocytosis: Difference between revisions

Latest revision as of 17:12, 16 October 2018

Overview

Differentiating Anemia with normal reticulocytosis from Other Diseases

References

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