Anaphylaxis historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Dushka Riaz, MD

Overview

The term comes from the Greek words ana (against) and phylaxis (protection).

Discovery

  • Anaphylaxis was first discovered by Charles Richet and Paul Portier, who were French physiologists in 1913. They conducted a series of experiments on a dog by injecting a toxin that was repeated again later. They found an exaggerated immune response resulting in the dog experiencing collapse of the airway, breathing, and circulatory systems. [1]

Landmark Events in the Development of Treatment Strategies

In the year 1937, Daniel Bovet discovered antihistamines, and cortisone was introduced in the year 1949. [2], [2]

Impact on Cultural History

Famous Cases

The following are a few famous cases of [disease name]:

References

  1. Ring J, Behrendt H, de Weck A (2010). "History and classification of anaphylaxis". Chem Immunol Allergy. 95: 1–11. doi:10.1159/000315934. PMID 20519878.
  2. 2.0 2.1 LoVerde D, Iweala OI, Eginli A, Krishnaswamy G (2018). "Anaphylaxis". Chest. 153 (2): 528–543. doi:10.1016/j.chest.2017.07.033. PMC 6026262. PMID 28800865.

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