Amyloidosis electrocardiogram

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]

Overview

Electrocardiogram is particularly useful for cardiac amyloidosis. Findings on electrocardiogram include a variety of findings.

Electrocardiogram

Electrocardiogram is particularly useful for cardiac amyloidosis. Findings on electrocardiogram include:

  • Low voltage QRS complexes[1]: Low voltages are present due to infiltrative heart disease and the reduced electrical conduction through the cardiac muscle.
  • Left ventricular hypertrophy[2]
  • Right ventricular hypertrophy[2]
  • Left atrial abnormalities
  • Pathological Q waves[2]
  • Atrioventricular block: AV block occur due to deposition of amyloid fibrils in the conduction tissue.
    • First-degree AV block
    • Second-degree AV block
    • Third-degree AV block

References

  1. Guan J, Mishra S, Falk RH, Liao R (2012). "Current perspectives on cardiac amyloidosis". Am J Physiol Heart Circ Physiol. 302 (3): H544–52. doi:10.1152/ajpheart.00815.2011. PMC 3353775. PMID 22058156.
  2. 2.0 2.1 2.2 Damy T, Judge DP, Kristen AV, Berthet K, Li H, Aarts J (2015). "Cardiac findings and events observed in an open-label clinical trial of tafamidis in patients with non-Val30Met and non-Val122Ile hereditary transthyretin amyloidosis". J Cardiovasc Transl Res. 8 (2): 117–27. doi:10.1007/s12265-015-9613-9. PMC 4382536. PMID 25743445.

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