Amyloidosis causes: Difference between revisions

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* ''Dialysis related amyloidosis'' (the precursor protein is [[beta-2-microglobulin]] which is not removed with [[dialysis]], and thus accumulates in patients with [[end stage renal failure]] on dialysis).
* ''Dialysis related amyloidosis'' (the precursor protein is [[beta-2-microglobulin]] which is not removed with [[dialysis]], and thus accumulates in patients with [[end stage renal failure]] on dialysis).


=== Organ-specific amyloidosis ===
===Organ-Specific Amyloidosis===
In almost all of the organ-specific pathologies, there is '''significant debate''' as to whether the amyloid plaques are the causal agent of the disease or instead a downstream consequence of a common [[idiopathic]] agent.  The associated proteins are indicated in parentheses.   
In almost all of the organ-specific pathologies, there is '''significant debate''' as to whether the amyloid plaques are the causal agent of the disease or instead a downstream consequence of a common [[idiopathic]] agent.  The associated proteins are indicated in parentheses.   



Revision as of 13:13, 26 November 2012

Amyloidosis Microchapters

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Patient Information

Overview

Historical Perspective

Classification

Primary amyloidosis
Secondary amyloidosis
Familial amyloidosis
Wild-type (senile) amyloidosis
Cardiac amyloidosis
Beta-2 microglobulin related amyloidosis
Gelsolin related amyloidosis
Lysozyme amyloid related amyloidosis
Leucocyte cell-derived chemotaxin 2 related amyloidosis
Fibrinogen A alpha-chain associated amyloidosis

Pathophysiology

Causes

Differentiating Amyloidosis from other Diseases

Epidemiology and Demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Amyloidosis can be systemic or organ specific. In systemic amyloidosis, the secondary form (AL, AA) is much more common than the primary form.

Causes

Systemic Amyloidosis

Primary/Hereditary Amyloidosis

These rare hereditary disorders are usually due to point mutations in precursor proteins, and are also usually autosomal dominantly transmitted. The precursor proteins are:

Secondary Amyloidosis

These are far more common than the primary amyloidoses.

Organ-Specific Amyloidosis

In almost all of the organ-specific pathologies, there is significant debate as to whether the amyloid plaques are the causal agent of the disease or instead a downstream consequence of a common idiopathic agent. The associated proteins are indicated in parentheses.

Neurological amyloid

Cardiovascular amyloid

Other

References

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