Alport syndrome natural history, complications and prognosis: Difference between revisions
No edit summary |
Rim Halaby (talk | contribs) |
||
| Line 5: | Line 5: | ||
Please help WikiDoc by adding more content here. It's easy! Click [[Help:How_to_Edit_a_Page|here]] to learn about editing. | Please help WikiDoc by adding more content here. It's easy! Click [[Help:How_to_Edit_a_Page|here]] to learn about editing. | ||
==Natural History== | ==Natural History== | ||
Recognition of Alport’s syndrome based on the clinical presentation and distinguishing it from other causes of hematuria or extra renal manifestations is important because Alport’s syndrome usually carries a poor prognosis with inevitable progression to end-stage renal disease (ESRD).<ref name="pmid23349312">{{cite journal| author=Savige J, Gregory M, Gross O, Kashtan C, Ding J, Flinter F| title=Expert guidelines for the management of Alport syndrome and thin basement membrane nephropathy. | journal=J Am Soc Nephrol | year= 2013 | volume= 24 | issue= 3 | pages= 364-75 | pmid=23349312 | doi=10.1681/ASN.2012020148 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23349312 }} </ref> Onset of symptoms often starts during infancy in X-linked Alport’s syndrome; patients reach ESRD during adolescence (23349312). Patients with autosomal recessive Alport’s syndrome sometimes progress less rapidly; although they may still progress to ESRD early, they may reach ESRD during adult life.<ref name="pmid23349312">{{cite journal| author=Savige J, Gregory M, Gross O, Kashtan C, Ding J, Flinter F| title=Expert guidelines for the management of Alport syndrome and thin basement membrane nephropathy. | journal=J Am Soc Nephrol | year= 2013 | volume= 24 | issue= 3 | pages= 364-75 | pmid=23349312 | doi=10.1681/ASN.2012020148 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23349312 }} </ref> | |||
==Complications== | ==Complications== | ||
*[[Chronic kidney disease]] | *[[Chronic kidney disease]] | ||
Revision as of 20:05, 31 October 2013
|
Alport syndrome Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Alport syndrome natural history, complications and prognosis On the Web |
|
American Roentgen Ray Society Images of Alport syndrome natural history, complications and prognosis |
|
FDA on Alport syndrome natural history, complications and prognosis |
|
CDC on Alport syndrome natural history, complications and prognosis |
|
Alport syndrome natural history, complications and prognosis in the news |
|
Blogs on Alport syndrome natural history, complications and prognosis |
|
Risk calculators and risk factors for Alport syndrome natural history, complications and prognosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Please help WikiDoc by adding more content here. It's easy! Click here to learn about editing.
Natural History
Recognition of Alport’s syndrome based on the clinical presentation and distinguishing it from other causes of hematuria or extra renal manifestations is important because Alport’s syndrome usually carries a poor prognosis with inevitable progression to end-stage renal disease (ESRD).[1] Onset of symptoms often starts during infancy in X-linked Alport’s syndrome; patients reach ESRD during adolescence (23349312). Patients with autosomal recessive Alport’s syndrome sometimes progress less rapidly; although they may still progress to ESRD early, they may reach ESRD during adult life.[1]
Complications
Prognosis
Women usually have a normal lifespan with no signs of the disease except for blood in the urine. Rarely, women will have high blood pressure, swelling, and nerve deafness as a complication of pregnancy. In men, deafness, vision problems, and end-stage kidney disease are likely by age 50.
References
- ↑ 1.0 1.1 Savige J, Gregory M, Gross O, Kashtan C, Ding J, Flinter F (2013). "Expert guidelines for the management of Alport syndrome and thin basement membrane nephropathy". J Am Soc Nephrol. 24 (3): 364–75. doi:10.1681/ASN.2012020148. PMID 23349312.