Adrenocortical carcinoma staging

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]

Overview

According to the TNM staging system, there are four stages of adrenocortical cancer based on the tumor size, lymph nodes, and distant metastasis. Each stage is assigned a number and letter that designates the number of lymph nodes involved and presence/absence of distant metastasis.

Staging of adrenocortical carcinoma

The AJCC has designated staging by TNM to define adrenocortical carcinoma

Staging according to TNM staging system

Stage T N M
I T1 N0 M0
II T2 N0 M0
III T1 N1 M0
T2 N1 M0
T3 N0 M0
IV T3 N1 M0
T4 N0 M0
T4 N1 M0
Any T Any N M1

Tumor size (T)

TX Primary tumor cannot be assessed.
T0 No evidence of primary tumor.
T1 Tumor ≤5 cm in greatest dimension, no extra-adrenal invasion.
T2 Tumor >5 cm, no extra-adrenal invasion.
T3 Tumor of any size with local invasion, but not invading adjacent organs.
T4 Tumor of any size with invasion of adjacent organs.

Lymph nodes (N)

NX Regional lymph nodes cannot be assessed.
N0 No regional lymph node metastasis.
N1 Metastases in regional lymph node(s).

Metastasis (M)

M0 No distant metastasis.
M1 Distant metastasis.

References

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