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{{Acute respiratory distress syndrome}}
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==Overview==
==Overview==
Although the pathologic features of ARDS were first documented in the 19th century, the modern definition of ARDS did not arise until the 1960s. The diagnostic criteria of ARDS have continued to evolve over the latter half of the 20th century and into the 21st century, and they continue to evolve in tandem with our ability to diagnose the syndrome earlier on in its clinical course.
Although the pathologic features of acute respiratory distress syndrome (ARDS) were first documented in the 19<sup>th</sup> century, characterization of its clinical features did not arise until the 1960s. The most recently updated definition is the Berlin definition devised by the European Society of Intensive Care Medicine in 2012.


==Historical Perspective==
==Historical Perspective==
Although the first pathologic descriptions of what was likely ARDS date back to the 19th century, our understanding of the distinct pathophysiologic features of ARDS evolved alongside the development of medical technologies that facilitated a more in-depth study of the syndrome. The advent of [[projectional radiography|radiography]] permitted visualization of the bilateral [[pulmonary infiltrates]] (originally termed ''double [[pneumonia]]''), while the development of [[ABG|arterial blood gas measurement]] and [[mechanical ventilation|positive-pressure mechanical ventilation]] allowed for identification of the impaired [[oxygenation]] and reduced [[lung compliance]] that are now recognized as central features of ARDS.<ref name="pmid16020801">{{cite journal| author=Bernard GR| title=Acute respiratory distress syndrome: a historical perspective. | journal=Am J Respir Crit Care Med | year= 2005 | volume= 172 | issue= 7 | pages= 798-806 | pmid=16020801 | doi=10.1164/rccm.200504-663OE | pmc=2718401 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16020801  }} </ref>
Although the first pathologic description of ARDS dates back to 1821,<ref>Laennec, René Théophile Hyacinthe, and Sir John Forbes. A Treatise on the Diseases of the Chest, and on Mediate Auscultation. Samuel S. and William Wood, 1838.</ref> our understanding of the distinct pathophysiologic features of ARDS has volved alongside the development of medical technologies that facilitated a more in-depth study of the syndrome. The advent of [[projectional radiography|radiography]] permitted visualization of the bilateral pulmonary infiltrates (originally termed ''double [[pneumonia]]''), while the development of [[ABG|arterial blood gas measurement]] and [[mechanical ventilation|positive-pressure mechanical ventilation]] allowed for identification of the impaired [[oxygenation]] and reduced [[pulmonary compliance|lung compliance]] that are now recognized as central features of ARDS.<ref name="pmid16020801">{{cite journal| author=Bernard GR| title=Acute respiratory distress syndrome: a historical perspective. | journal=Am J Respir Crit Care Med | year= 2005 | volume= 172 | issue= 7 | pages= 798-806 | pmid=16020801 | doi=10.1164/rccm.200504-663OE | pmc=2718401 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16020801  }} </ref>


Ashbaugh and colleagues published he first description of what is now widely recognized as ARDS in a [[case series]] of 12 patients with rapidly progressive [[respiratory failure]] with bilateral pulmonary infiltrates and profound [[hypoxemia]] following [[trauma]] or [[infection]] in ''The Lancet'' in 1967.<ref name="pmid4143721">{{cite journal| author=Ashbaugh DG, Bigelow DB, Petty TL, Levine BE| title=Acute respiratory distress in adults. | journal=Lancet | year= 1967 | volume= 2 | issue= 7511 | pages= 319-23 | pmid=4143721 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4143721  }} </ref> The clinical syndrome was called the "adult respiratory distress syndrome" (ARDS) to distinguish it from the respiratory distress syndrome of infancy due to [[hyaline membrane disease]], although the ''A'' in ARDS was later changed from ''acute'' to ''adult'' once it was recognized that the syndrome could also present in infants as a distinct entity from hyaline membrane disease.
In 1967, Ashbaugh and colleagues first described the clinical entity "acute respiratory distress in adults" characterized by a clinical and pathological course of events remarkably similar to the [[Neonatal respiratory distress syndrome|infantile respiratory distress syndrome]].<ref name="pmid4143721">{{cite journal| author=Ashbaugh DG, Bigelow DB, Petty TL, Levine BE| title=Acute respiratory distress in adults. | journal=Lancet | year= 1967 | volume= 2 | issue= 7511 | pages= 319-23 | pmid=4143721 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4143721  }} </ref> In the [[case series]], 12 patients developed severe [[dyspnea]], [[tachypnea]], [[cyanosis]] refractory to [[oxygen therapy]], decreased [[pulmonary compliance]], and diffuse [[Alveolar lung disease|alveolar infiltration]] following [[trauma]], [[virus|viral]] [[infection]], or [[acute pancreatitis]]. Autopsy findings of the [[lungs]] include [[atelectasis]], [[vascular congestion]], [[hemorrhage]], [[pulmonary edema]], and [[hyaline]] membrane formation.


Until the formulation of the Berlin Definition of ARDS in 2012, the most widely used definition of ARDS was formulated by the American European Consensus Conference (AECC) in 1994. The AECC considered ARDS to be a severe form of [[acute lung injury|''acute lung injury'' (ALI)]], which they defined as a syndrome of lung [[inflammation]] and [[edema]] that could not be explained be elevated [[left atrial pressure]]. Their diagnostic criteria for ALI and ARDS were:<ref name="pmid16020801">{{cite journal| author=Bernard GR| title=Acute respiratory distress syndrome: a historical perspective. | journal=Am J Respir Crit Care Med | year= 2005 | volume= 172 | issue= 7 | pages= 798-806 | pmid=16020801 | doi=10.1164/rccm.200504-663OE | pmc=2718401 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16020801  }} </ref>
In 1988, Murray et al. proposed an expanded definition of ARDS that utilized a four-point lung injury scoring system to assess the physiologic respiratory impairment based on [[oxygenation]] status, level of [[positive end-expiratory pressure]], static [[pulmonary compliance]], and [[chest radiograph]] involvement.<ref>Murray, J. F., M. A. Matthay, J. M. Luce, and M. R. Flick. “An Expanded Definition of the Adult Respiratory Distress Syndrome.” The American Review of Respiratory Disease 138, no. 3 (September 1988): 720–23. doi:10.1164/ajrccm/138.3.720.</ref> Although the scoring system may be used to quantify the extent of lung injury in the research setting, the lack of survival predictability has limited its clinical usefulness.<ref>Doyle, R. L., N. Szaflarski, G. W. Modin, J. P. Wiener-Kronish, and M. A. Matthay. “Identification of Patients with Acute Lung Injury. Predictors of Mortality.” American Journal of Respiratory and Critical Care Medicine 152, no. 6 Pt 1 (December 1995): 1818–24. doi:10.1164/ajrccm.152.6.8520742.</ref><ref>Zilberberg, Marya D., and Scott K. Epstein. “Acute Lung Injury in the Medical ICU.” American Journal of Respiratory and Critical Care Medicine 157, no. 4 (April 1, 1998): 1159–64. doi:10.1164/ajrccm.157.4.9704088.</ref>
*Acute onset, bilateral infiltrates on [[chest radiography]]
*[[pulmonary capillary wedge pressure|Pulmonary-artery wedge pressure]] of < 19 mm Hg or the absence of clinical evidence of left atrial hypertension
*[[Pulmonary gas pressures|Arterial partial pressure of oxygen (PaO<sub>2</sub>)]]/[[fraction of inspired oxygen|fraction of inspired oxygen (FIO<sub>2</sub>)]] ≤ 300 for ALI ''or'' ≤ 200 for ARDS


The AECC definition of ARDS was largely superseded by the [[Acute respiratory distress syndrome#Diagnostic criteria||Berlin Definition]] of ARDS, published in 2012 by the ARDS Definition Task Force.<ref name="pmid22797452">{{cite journal| author=ARDS Definition Task Force. Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E et al.| title=Acute respiratory distress syndrome: the Berlin Definition. | journal=JAMA | year= 2012 | volume= 307 | issue= 23 | pages= 2526-33 | pmid=22797452 | doi=10.1001/jama.2012.5669 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22797452  }} </ref> In formulating their diagnostic criteria, the ARDS Definition Task Force removed the distinction between ALI and ARDS, choosing instead to risk-stratify ARDS according to severity (''mild'', ''moderate'', or ''severe''), each with its own associated mortality risk based on data from a large patient population. According to the Berlin Definition, what was once ALI is now classified as ''mild ARDS.''
In 1994, a standardized definition of ARDS was devised by the American European Consensus Conference (AECC).<ref>“The American-European Consensus Conference on ARDS. Definitions, Mechanisms, Relevant Outcomes, and Clinical Trial Coordination. (ATS Journals).” http://www.atsjournals.org/doi/abs/10.1164/ajrccm.149.3.7509706.</ref> The AECC committee defined [[acute lung injury|acute lung injury (ALI)]] as "a syndrome of [[inflammation]] and increased [[permeability]] that is associated with a constellation of clinical, radiologic, and physiologic abnormalities that cannot be explained by, but may coexist with, [[Pulmonary wedge pressure|left atrial or pulmonary capillary hypertension]]" that "is associated most often with [[sepsis syndrome]], [[aspiration]], primary [[pneumonia]], or multiple [[trauma]]". The term ARDS was reserved for the end of this spectrum with the most severe [[oxygenation]] deficit. ALI and ARDS are acute in onset and persistent, are associated with one or more known risk factors, and are characterized by arterial [[hypoxemia]] resistant to [[oxygen therapy]] alone and diffuse radiologic infiltrates. Despite the wide acceptance of the AECC definition, there are limitations across all four diagnostic criteria such as unspecified timing of acute onset, no minimum requirement of [[PEEP]] which can influence [[oxygenation]] status, and poor inter-observer agreement on interpretation of [[chest radiograph]]s or [[pulmonary artery catheter]] tracings.<ref>Sweeney, Rob Mac, and Daniel F. McAuley. “Acute Respiratory Distress Syndrome.” Lancet (London, England), April 28, 2016. doi:10.1016/S0140-6736(16)00578-X.</ref>
 
In 2012, the AECC definition was superseded by the [[Acute respiratory distress syndrome diagnostic criteria|Berlin definition]] from the European Society of Intensive Care Medicine.<ref>The ARDS Definition Task Force*. “Acute Respiratory Distress Syndrome: The Berlin Definition.JAMA 307, no. 23 (June 20, 2012): 2526–33. doi:10.1001/jama.2012.5669.</ref> The major changes to the Berlin definition of ARDS include: the term ALI was removed, [[pulmonary capillary wedge pressure|pulmonary artery wedge pressure]] requirement was removed, subgroups by severity of [[oxygenation]] deficit were added, minimal [[PEEP]] or [[CPAP]] levels across subgroups were added, and chest [[CT]] was incorporated as an alternative imaging modality for determination of lung infiltrates. Data from the pooled cohorts suggested that each stage is associated with a progressive increase in the [[mortality]] as well as the duration of [[mechanical ventilation]] among survivors. Compared with the AECC definition, the Berlin definition was deemed to be a better predictor of [[mortality]] among patients with ARDS.<ref>The ARDS Definition Task Force*. “Acute Respiratory Distress Syndrome: The Berlin Definition.” JAMA 307, no. 23 (June 20, 2012): 2526–33. doi:10.1001/jama.2012.5669.</ref>


==References==
==References==
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[[Category:Pulmonology]]
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{{WH}}

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Brian Shaller, M.D. [2]

Overview

Although the pathologic features of acute respiratory distress syndrome (ARDS) were first documented in the 19th century, characterization of its clinical features did not arise until the 1960s. The most recently updated definition is the Berlin definition devised by the European Society of Intensive Care Medicine in 2012.

Historical Perspective

Although the first pathologic description of ARDS dates back to 1821,[1] our understanding of the distinct pathophysiologic features of ARDS has volved alongside the development of medical technologies that facilitated a more in-depth study of the syndrome. The advent of radiography permitted visualization of the bilateral pulmonary infiltrates (originally termed double pneumonia), while the development of arterial blood gas measurement and positive-pressure mechanical ventilation allowed for identification of the impaired oxygenation and reduced lung compliance that are now recognized as central features of ARDS.[2]

In 1967, Ashbaugh and colleagues first described the clinical entity "acute respiratory distress in adults" characterized by a clinical and pathological course of events remarkably similar to the infantile respiratory distress syndrome.[3] In the case series, 12 patients developed severe dyspnea, tachypnea, cyanosis refractory to oxygen therapy, decreased pulmonary compliance, and diffuse alveolar infiltration following trauma, viral infection, or acute pancreatitis. Autopsy findings of the lungs include atelectasis, vascular congestion, hemorrhage, pulmonary edema, and hyaline membrane formation.

In 1988, Murray et al. proposed an expanded definition of ARDS that utilized a four-point lung injury scoring system to assess the physiologic respiratory impairment based on oxygenation status, level of positive end-expiratory pressure, static pulmonary compliance, and chest radiograph involvement.[4] Although the scoring system may be used to quantify the extent of lung injury in the research setting, the lack of survival predictability has limited its clinical usefulness.[5][6]

In 1994, a standardized definition of ARDS was devised by the American European Consensus Conference (AECC).[7] The AECC committee defined acute lung injury (ALI) as "a syndrome of inflammation and increased permeability that is associated with a constellation of clinical, radiologic, and physiologic abnormalities that cannot be explained by, but may coexist with, left atrial or pulmonary capillary hypertension" that "is associated most often with sepsis syndrome, aspiration, primary pneumonia, or multiple trauma". The term ARDS was reserved for the end of this spectrum with the most severe oxygenation deficit. ALI and ARDS are acute in onset and persistent, are associated with one or more known risk factors, and are characterized by arterial hypoxemia resistant to oxygen therapy alone and diffuse radiologic infiltrates. Despite the wide acceptance of the AECC definition, there are limitations across all four diagnostic criteria such as unspecified timing of acute onset, no minimum requirement of PEEP which can influence oxygenation status, and poor inter-observer agreement on interpretation of chest radiographs or pulmonary artery catheter tracings.[8]

In 2012, the AECC definition was superseded by the Berlin definition from the European Society of Intensive Care Medicine.[9] The major changes to the Berlin definition of ARDS include: the term ALI was removed, pulmonary artery wedge pressure requirement was removed, subgroups by severity of oxygenation deficit were added, minimal PEEP or CPAP levels across subgroups were added, and chest CT was incorporated as an alternative imaging modality for determination of lung infiltrates. Data from the pooled cohorts suggested that each stage is associated with a progressive increase in the mortality as well as the duration of mechanical ventilation among survivors. Compared with the AECC definition, the Berlin definition was deemed to be a better predictor of mortality among patients with ARDS.[10]

References

  1. Laennec, René Théophile Hyacinthe, and Sir John Forbes. A Treatise on the Diseases of the Chest, and on Mediate Auscultation. Samuel S. and William Wood, 1838.
  2. Bernard GR (2005). "Acute respiratory distress syndrome: a historical perspective". Am J Respir Crit Care Med. 172 (7): 798–806. doi:10.1164/rccm.200504-663OE. PMC 2718401. PMID 16020801.
  3. Ashbaugh DG, Bigelow DB, Petty TL, Levine BE (1967). "Acute respiratory distress in adults". Lancet. 2 (7511): 319–23. PMID 4143721.
  4. Murray, J. F., M. A. Matthay, J. M. Luce, and M. R. Flick. “An Expanded Definition of the Adult Respiratory Distress Syndrome.” The American Review of Respiratory Disease 138, no. 3 (September 1988): 720–23. doi:10.1164/ajrccm/138.3.720.
  5. Doyle, R. L., N. Szaflarski, G. W. Modin, J. P. Wiener-Kronish, and M. A. Matthay. “Identification of Patients with Acute Lung Injury. Predictors of Mortality.” American Journal of Respiratory and Critical Care Medicine 152, no. 6 Pt 1 (December 1995): 1818–24. doi:10.1164/ajrccm.152.6.8520742.
  6. Zilberberg, Marya D., and Scott K. Epstein. “Acute Lung Injury in the Medical ICU.” American Journal of Respiratory and Critical Care Medicine 157, no. 4 (April 1, 1998): 1159–64. doi:10.1164/ajrccm.157.4.9704088.
  7. “The American-European Consensus Conference on ARDS. Definitions, Mechanisms, Relevant Outcomes, and Clinical Trial Coordination. (ATS Journals).” http://www.atsjournals.org/doi/abs/10.1164/ajrccm.149.3.7509706.
  8. Sweeney, Rob Mac, and Daniel F. McAuley. “Acute Respiratory Distress Syndrome.” Lancet (London, England), April 28, 2016. doi:10.1016/S0140-6736(16)00578-X.
  9. The ARDS Definition Task Force*. “Acute Respiratory Distress Syndrome: The Berlin Definition.” JAMA 307, no. 23 (June 20, 2012): 2526–33. doi:10.1001/jama.2012.5669.
  10. The ARDS Definition Task Force*. “Acute Respiratory Distress Syndrome: The Berlin Definition.” JAMA 307, no. 23 (June 20, 2012): 2526–33. doi:10.1001/jama.2012.5669.