Acute disseminated encephalomyelitis natural history, complications and prognosis: Difference between revisions
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==Natural History== | ==Natural History== | ||
*The classic form, accounting for 70-90% of cases, typically follows a [[monophasic]] pattern<ref name="pmid15295226">{{cite journal| author=Leake JA, Albani S, Kao AS, Senac MO, Billman GF, Nespeca MP | display-authors=etal| title=Acute disseminated encephalomyelitis in childhood: epidemiologic, clinical and laboratory features. | journal=Pediatr Infect Dis J | year= 2004 | volume= 23 | issue= 8 | pages= 756-64 | pmid=15295226 | doi=10.1097/01.inf.0000133048.75452.dd | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15295226 }} </ref><ref name="pmid12391351">{{cite journal| author=Tenembaum S, Chamoles N, Fejerman N| title=Acute disseminated encephalomyelitis: a long-term follow-up study of 84 pediatric patients. | journal=Neurology | year= 2002 | volume= 59 | issue= 8 | pages= 1224-31 | pmid=12391351 | doi=10.1212/wnl.59.8.1224 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12391351 }} </ref>. However, [[multiphasic]] [[disease]] progression ([[M-ADEM]]) has also been previously reported. | |||
*The lag period between [[onset]] to first [[relapse]] can vary from 2 months to 8 years, with one case showing [[recurrence]] after three decades. | |||
* Most of [[M-ADEM]] patients demonstrate resolution of [[lesions]] with no [[neurological]] [[sequelae]] on long-term [[clinical]] and [[imaging]] follow-up. | |||
*[[MRI]] of patients with co-existent [[M-ADEM]] and [[anti-MOG]] [[antibodies]] typically reveal no new [[lesions]] in the [[asymptomatic period]]. | |||
==[[Complications]]== | ==[[Complications]]== | ||
==[[Prognosis]]== | ==[[Prognosis]]== |
Revision as of 07:04, 15 November 2022
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sujaya Chattopadhyay, M.D.[2]
Overview
Natural History
- The classic form, accounting for 70-90% of cases, typically follows a monophasic pattern[1][2]. However, multiphasic disease progression (M-ADEM) has also been previously reported.
- The lag period between onset to first relapse can vary from 2 months to 8 years, with one case showing recurrence after three decades.
- Most of M-ADEM patients demonstrate resolution of lesions with no neurological sequelae on long-term clinical and imaging follow-up.
- MRI of patients with co-existent M-ADEM and anti-MOG antibodies typically reveal no new lesions in the asymptomatic period.
Complications
Prognosis
References
- ↑ Leake JA, Albani S, Kao AS, Senac MO, Billman GF, Nespeca MP; et al. (2004). "Acute disseminated encephalomyelitis in childhood: epidemiologic, clinical and laboratory features". Pediatr Infect Dis J. 23 (8): 756–64. doi:10.1097/01.inf.0000133048.75452.dd. PMID 15295226.
- ↑ Tenembaum S, Chamoles N, Fejerman N (2002). "Acute disseminated encephalomyelitis: a long-term follow-up study of 84 pediatric patients". Neurology. 59 (8): 1224–31. doi:10.1212/wnl.59.8.1224. PMID 12391351.