Acipimox

Acipimox

Skeletal formula
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	C10AD06 (WHO)
Identifiers
IUPAC name 5-carboxy-2-methyl-1-oxidopyrazin-1-ium
CAS Number	51037-30-0 Y
PubChem CID	5310993
ChemSpider	4470534 Y
UNII	K9AY9IR2SD
KEGG	D07190 Y
ChEMBL	ChEMBL345714 Y
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C6H6N2O3
Molar mass	154.124 g/mol
3D model (JSmol)	Interactive image
SMILES [O-][n+]1c(cnc(C(=O)O)c1)C
InChI InChI=1S/C6H6N2O3/c1-4-2-7-5(6(9)10)3-8(4)11/h2-3H,1H3,(H,9,10) Y Key:DJQOOSBJCLSSEY-UHFFFAOYSA-N Y
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Evidence Based Medicine
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Clinical Trials
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Experimental / Informatics
List of terms related to Acipimox

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Acipimox is a niacin derivative used as a hypolipidemic agent. It is used in low doses and may have less marked adverse effects, although it is unclear whether the recommended dose is as effective as are standard doses of nicotinic acid. Acipimox inhibits the production of triglycerides by the liver and the secretion of VLDL, which leads indirectly to a modest reduction in LDL and increase in HDL. Long-term administration is associated with reduced mortality, but unwanted effects limit its clinical use. Adverse effects include flushing (associated with Prostaglandin D2), palpitations, and GI disturbances. Flushing can be reduced by taking aspirin 20-30 min before taking Acipimox. High doses can cause disorders of liver function, impair glucose tolerance and precipitate gout.