WASF3
WAS protein family, member 3 | |||||||||||
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Identifiers | |||||||||||
Symbols | WASF3 ; KIAA0900; SCAR3; WAVE3 | ||||||||||
External IDs | Template:OMIM5 Template:MGI HomoloGene: 68527 | ||||||||||
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RNA expression pattern | |||||||||||
File:PBB GE WASF3 204042 at tn.png | |||||||||||
More reference expression data | |||||||||||
Orthologs | |||||||||||
Template:GNF Ortholog box | |||||||||||
Species | Human | Mouse | |||||||||
Entrez | n/a | n/a | |||||||||
Ensembl | n/a | n/a | |||||||||
UniProt | n/a | n/a | |||||||||
RefSeq (mRNA) | n/a | n/a | |||||||||
RefSeq (protein) | n/a | n/a | |||||||||
Location (UCSC) | n/a | n/a | |||||||||
PubMed search | n/a | n/a |
WAS protein family, member 3, also known as WASF3, is a human gene.[1]
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.[1]
References
Further reading
- Jones GE (2000). "Cellular signaling in macrophage migration and chemotaxis". J. Leukoc. Biol. 68 (5): 593–602. PMID 11073096.
- Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. PMID 12168954.
- Schott DR, Chang JN, Deng G; et al. (1994). "A candidate tumor suppressor gene in human breast cancers". Cancer Res. 54 (6): 1393–6. PMID 8137235.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.
- Bear JE, Rawls JF, Saxe CL (1998). "SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development". J. Cell Biol. 142 (5): 1325–35. PMID 9732292.
- Nagase T, Ishikawa K, Suyama M; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. PMID 10048485.
- Suetsugu S, Miki H, Takenawa T (1999). "Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex". Biochem. Biophys. Res. Commun. 260 (1): 296–302. doi:10.1006/bbrc.1999.0894. PMID 10381382.
- Marchand JB, Kaiser DA, Pollard TD, Higgs HN (2001). "Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex". Nat. Cell Biol. 3 (1): 76–82. doi:10.1038/35050590. PMID 11146629.
- Millard TH, Machesky LM (2001). "The Wiskott-Aldrich syndrome protein (WASP) family". Trends Biochem. Sci. 26 (3): 198–9. PMID 11246027.
- Sossey-Alaoui K, Su G, Malaj E; et al. (2002). "WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma". Oncogene. 21 (38): 5967–74. doi:10.1038/sj.onc.1205734. PMID 12185600.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Sossey-Alaoui K, Head K, Nowak N, Cowell JK (2003). "Genomic organization and expression profile of the human and mouse WAVE gene family". Mamm. Genome. 14 (5): 314–22. doi:10.1007/s00335-002-2247-7. PMID 12856283.
- Dunham A, Matthews LH, Burton J; et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMID 15057823.
- Oda A, Miki H, Wada I; et al. (2005). "WAVE/Scars in platelets". Blood. 105 (8): 3141–8. doi:10.1182/blood-2003-04-1319. PMID 15280206.
- Kashiwagi H, Shiraga M, Kato H; et al. (2005). "Expression and subcellular localization of WAVE isoforms in the megakaryocyte/platelet lineage". J. Thromb. Haemost. 3 (2): 361–8. doi:10.1111/j.1538-7836.2004.01082.x. PMID 15670045.
- Stovold CF, Millard TH, Machesky LM (2006). "Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2". BMC Cell Biol. 6 (1): 11. doi:10.1186/1471-2121-6-11. PMID 15752430.
- Sossey-Alaoui K, Li X, Ranalli TA, Cowell JK (2005). "WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinase". J. Biol. Chem. 280 (23): 21748–55. doi:10.1074/jbc.M500503200. PMID 15826941.
- Sossey-Alaoui K, Ranalli TA, Li X; et al. (2005). "WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression". Exp. Cell Res. 308 (1): 135–45. doi:10.1016/j.yexcr.2005.04.011. PMID 15907837.
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