TRPV4

Transient receptor potential cation channel, subfamily V, member 4
Identifiers
Symbols	TRPV4 ; OTRPC4; TRP12; VR-OAC; VRL-2; VRL2; VROAC
External IDs	Template:OMIM5 Template:MGI HomoloGene: 11003
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:219516 at
File:61963 at
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Transient receptor potential cation channel, subfamily V, member 4, also known as TRPV4, is a human gene.

This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Harteneck C, Plant TD, Schultz G (2000). "From worm to man: three subfamilies of TRP channels". Trends Neurosci. 23 (4): 159–66. PMID 10717675.CS1 maint: Multiple names: authors list (link)
• Clapham DE, Julius D, Montell C, Schultz G (2006). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.CS1 maint: Multiple names: authors list (link)
• Plant TD, Strotmann R (2007). "TRPV4". Handb Exp Pharmacol (179): 189–205. doi:10.1007/978-3-540-34891-7_11. PMID 17217058.
• Harteneck C, Reiter B (2007). "TRP channels activated by extracellular hypo-osmoticity in epithelia". Biochem. Soc. Trans. 35 (Pt 1): 91–5. doi:10.1042/BST0350091. PMID 17233610.