TCF21 (gene)

Transcription factor 21
Identifiers
Symbols	TCF21 ; POD1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2414
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TCF21 204931 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Transcription factor 21, also known as TCF21, is a human gene.

TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene.

Further reading

• Littlewood TD, Evan GI (1995). "Transcription factors 2: helix-loop-helix". Protein profile. 2 (6): 621–702. PMID 7553065.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Quaggin SE, Vanden Heuvel GB, Igarashi P (1998). "Pod-1, a mesoderm-specific basic-helix-loop-helix protein expressed in mesenchymal and glomerular epithelial cells in the developing kidney". Mech. Dev. 71 (1–2): 37–48. PMID 9507058.CS1 maint: Multiple names: authors list (link)
• Hidai H, Bardales R, Goodwin R; et al. (1998). "Cloning of capsulin, a basic helix-loop-helix factor expressed in progenitor cells of the pericardium and the coronary arteries". Mech. Dev. 73 (1): 33–43. PMID 9545526.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Robb L, Mifsud L, Hartley L; et al. (1999). "epicardin: A novel basic helix-loop-helix transcription factor gene expressed in epicardium, branchial arch myoblasts, and mesenchyme of developing lung, gut, kidney, and gonads". Dev. Dyn. 213 (1): 105–13. doi:10.1002/(SICI)1097-0177(199809)213:1<105::AID-AJA10>3.0.CO;2-1. PMID 9733105.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Quaggin SE, Schwartz L, Cui S; et al. (2000). "The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis". Development. 126 (24): 5771–83. PMID 10572052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki H, Fukunishi Y, Kagawa I; et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMID 11591653.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Funato N, Ohyama K, Kuroda T, Nakamura M (2003). "Basic helix-loop-helix transcription factor epicardin/capsulin/Pod-1 suppresses differentiation by negative regulation of transcription". J. Biol. Chem. 278 (9): 7486–93. doi:10.1074/jbc.M212248200. PMID 12493738.CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Smith LT, Lin M, Brena RM; et al. (2006). "Epigenetic regulation of the tumor suppressor gene TCF21 on 6q23-q24 in lung and head and neck cancer". Proc. Natl. Acad. Sci. U.S.A. 103 (4): 982–7. doi:10.1073/pnas.0510171102. PMID 16415157.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)