SGK3

Serum/glucocorticoid regulated kinase family, member 3
File:PBB Protein SGK3 image.jpg PDB rendering based on 1xte.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1xte​, 1xtn​
Identifiers
Symbols	SGK3 ; SGK2; CISK; DKFZp781N0293; SGKL
External IDs	Template:OMIM5 Template:MGI HomoloGene: 56582
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SGK3 220038 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Serum/glucocorticoid regulated kinase family, member 3, also known as SGK3, is a human gene.

This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Further reading

• Lang F, Cohen P (2002). "Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms". Sci. STKE. 2001 (108): RE17. doi:10.1126/stke.2001.108.re17. PMID 11707620.
• Ali A, Hoeflich KP, Woodgett JR (2002). "Glycogen synthase kinase-3: properties, functions, and regulation". Chem. Rev. 101 (8): 2527–40. PMID 11749387.CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kobayashi T, Deak M, Morrice N, Cohen P (2000). "Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase". Biochem. J. 344 Pt 1: 189–97. PMID 10548550.CS1 maint: Multiple names: authors list (link)
• Dai F, Yu L, He H; et al. (2000). "Cloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1". Genomics. 62 (1): 95–7. doi:10.1006/geno.1999.5969. PMID 10585774.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fang X, Yu SX, Lu Y; et al. (2000). "Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A.". Proc. Natl. Acad. Sci. U.S.A. 97 (22): 11960–5. doi:10.1073/pnas.220413597. PMID 11035810.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu J, Liu D, Gill G, Songyang Z (2001). "Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides". J. Cell Biol. 154 (4): 699–705. doi:10.1083/jcb.200105089. PMID 11514587.CS1 maint: Multiple names: authors list (link)
• Yun CC, Chen Y, Lang F (2002). "Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2". J. Biol. Chem. 277 (10): 7676–83. doi:10.1074/jbc.M107768200. PMID 11751930.CS1 maint: Multiple names: authors list (link)
• Fang X, Yu S, Tanyi JL; et al. (2002). "Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway". Mol. Cell. Biol. 22 (7): 2099–110. PMID 11884598.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dai F, Yu L, He H; et al. (2002). "Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction". Biochem. Biophys. Res. Commun. 293 (4): 1191–6. doi:10.1016/S0006-291X(02)00349-2. PMID 12054501.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brickley DR, Mikosz CA, Hagan CR, Conzen SD (2003). "Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1)". J. Biol. Chem. 277 (45): 43064–70. doi:10.1074/jbc.M207604200. PMID 12218062.CS1 maint: Multiple names: authors list (link)
• Gamper N, Fillon S, Feng Y; et al. (2003). "K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK". Pflugers Arch. 445 (1): 60–6. doi:10.1007/s00424-002-0873-2. PMID 12397388.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Henke G, Setiawan I, Böhmer C, Lang F (2003). "Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms". Kidney Blood Press. Res. 25 (6): 370–4. doi:10.1159/000068699. PMID 12590200.CS1 maint: Multiple names: authors list (link)
• Friedrich B, Feng Y, Cohen P; et al. (2003). "The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC". Pflugers Arch. 445 (6): 693–6. doi:10.1007/s00424-002-0993-8. PMID 12632189.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Embark HM, Böhmer C, Vallon V; et al. (2003). "Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms". Pflugers Arch. 445 (5): 601–6. doi:10.1007/s00424-002-0982-y. PMID 12634932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nilsen T, Slagsvold T, Skjerpen CS; et al. (2004). "Peroxisomal targeting as a tool for assaying potein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner". J. Biol. Chem. 279 (6): 4794–801. doi:10.1074/jbc.M309653200. PMID 14604990.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)