PON3
| Paraoxonase 3 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | PON3 ; | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 37371 | ||||||||||
| |||||||||||
| RNA expression pattern | |||||||||||
| File:PBB GE PON3 213695 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Paraoxonase 3, also known as PON3, is a human gene.[1]
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized.[1]
References
Further reading
- Mackness B, Durrington PN, Mackness MI (2003). "The paraoxonase gene family and coronary heart disease". Curr. Opin. Lipidol. 13 (4): 357–62. PMID 12151850.
- Ng CJ, Shih DM, Hama SY; et al. (2005). "The paraoxonase gene family and atherosclerosis". Free Radic. Biol. Med. 38 (2): 153–63. doi:10.1016/j.freeradbiomed.2004.09.035. PMID 15607899.
- Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN (1996). "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family". Genomics. 33 (3): 498–507. PMID 8661009.
- La Du BN (2001). "Is paraoxonase-3 another hdl-associated protein protective against atherosclerosis?". Arterioscler. Thromb. Vasc. Biol. 21 (4): 467–8. PMID 11304457.
- Reddy ST, Wadleigh DJ, Grijalva V; et al. (2001). "Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids". Arterioscler. Thromb. Vasc. Biol. 21 (4): 542–7. PMID 11304470.
- Xu XR, Huang J, Xu ZG; et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMID 11752456.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
- Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
- Aharoni A, Gaidukov L, Yagur S; et al. (2004). "Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization". Proc. Natl. Acad. Sci. U.S.A. 101 (2): 482–7. doi:10.1073/pnas.2536901100. PMID 14695884.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Jin P, Fu GK, Wilson AD; et al. (2004). "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes". Genomics. 83 (4): 566–71. doi:10.1016/j.ygeno.2003.09.023. PMID 15028279.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Draganov DI, Teiber JF, Speelman A; et al. (2005). "Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities". J. Lipid Res. 46 (6): 1239–47. doi:10.1194/jlr.M400511-JLR200. PMID 15772423.
- Shamir R, Hartman C, Karry R; et al. (2005). "Paraoxonases (PONs) 1, 2, and 3 are expressed in human and mouse gastrointestinal tract and in Caco-2 cell line: selective secretion of PON1 and PON2". Free Radic. Biol. Med. 39 (3): 336–44. doi:10.1016/j.freeradbiomed.2005.03.016. PMID 15993332.
- Lu H, Zhu J, Zang Y; et al. (2005). "Cloning, high level expression of human paraoxonase-3 in Sf9 cells and pharmacological characterization of its product". Biochem. Pharmacol. 70 (7): 1019–25. doi:10.1016/j.bcp.2005.07.004. PMID 16099434.
- Lu H, Zhu J, Zang Y; et al. (2006). "Cloning, purification, and refolding of human paraoxonase-3 expressed in Escherichia coli and its characterization". Protein Expr. Purif. 46 (1): 92–9. doi:10.1016/j.pep.2005.07.021. PMID 16139510.
- Liu T, Qian WJ, Gritsenko MA; et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.
 | This protein-related article is a stub. You can help Wikipedia by expanding it. |