PIP5K1C
| Phosphatidylinositol-4-phosphate 5-kinase, type I, gamma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | PIP5K1C ; KIAA0589; PIP5K-GAMMA; PIP5Kgamma | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 69032 | ||||||||||
| |||||||||||
| RNA expression pattern | |||||||||||
| File:PBB GE PIP5K1C 212518 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Phosphatidylinositol-4-phosphate 5-kinase, type I, gamma, also known as PIP5K1C, is a human gene.[1]
This gene encodes a member of the type I phosphatidylinositol-4-phosphate 5-kinase family of enzymes. A similar protein in mice is found in synapses and focal adhesion plaques, and binds the FERM domain of talin through its C-terminus.[1]
References
Further reading
- Niiro H, Clark EA (2003). "Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1". Immunity. 19 (5): 637–40. PMID 14614850.
- Carpenter CL (2004). "Btk-dependent regulation of phosphoinositide synthesis". Biochem. Soc. Trans. 32 (Pt 2): 326–9. doi:10.1042/ Check
|doi=value (help). PMID 15046600. - Ishihara H, Shibasaki Y, Kizuki N; et al. (1998). "Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family". J. Biol. Chem. 273 (15): 8741–8. PMID 9535851.
- Nagase T, Ishikawa K, Miyajima N; et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. PMID 9628581.
- Gotthardt M, Trommsdorff M, Nevitt MF; et al. (2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". J. Biol. Chem. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173.
- Wenk MR, Pellegrini L, Klenchin VA; et al. (2001). "PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse". Neuron. 32 (1): 79–88. PMID 11604140.
- Di Paolo G, Pellegrini L, Letinic K; et al. (2002). "Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin". Nature. 420 (6911): 85–9. doi:10.1038/nature01147. PMID 12422219.
- Ling K, Doughman RL, Firestone AJ; et al. (2002). "Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions". Nature. 420 (6911): 89–93. doi:10.1038/nature01082. PMID 12422220.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Doughman RL, Firestone AJ, Wojtasiak ML; et al. (2003). "Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling". J. Biol. Chem. 278 (25): 23036–45. doi:10.1074/jbc.M211397200. PMID 12682053.
- Krauss M, Kinuta M, Wenk MR; et al. (2003). "ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma". J. Cell Biol. 162 (1): 113–24. doi:10.1083/jcb.200301006. PMID 12847086.
- Chang JD, Field SJ, Rameh LE; et al. (2004). "Identification and characterization of a phosphoinositide phosphate kinase homolog". J. Biol. Chem. 279 (12): 11672–9. doi:10.1074/jbc.M309721200. PMID 14701839.
- Grimwood J, Gordon LA, Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Wang YJ, Li WH, Wang J; et al. (2005). "Critical role of PIP5KI{gamma}87 in InsP3-mediated Ca(2+) signaling". J. Cell Biol. 167 (6): 1005–10. doi:10.1083/jcb.200408008. PMID 15611330.
- Bairstow SF, Ling K, Su X; et al. (2006). "Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis". J. Biol. Chem. 281 (29): 20632–42. doi:10.1074/jbc.M601465200. PMID 16707488.
- Krauss M, Kukhtina V, Pechstein A, Haucke V (2006). "Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2mu-cargo complexes". Proc. Natl. Acad. Sci. U.S.A. 103 (32): 11934–9. doi:10.1073/pnas.0510306103. PMID 16880396.
- Auvinen E, Kivi N, Vaheri A (2007). "Regulation of ezrin localization by Rac1 and PIPK in human epithelial cells". Exp. Cell Res. 313 (4): 824–33. doi:10.1016/j.yexcr.2006.12.002. PMID 17229424.
- Ling K, Bairstow SF, Carbonara C; et al. (2007). "Type Igamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with mu 1B adaptin". J. Cell Biol. 176 (3): 343–53. doi:10.1083/jcb.200606023. PMID 17261850.
 | This protein-related article is a stub. You can help Wikipedia by expanding it. |