PIK3CG

Phosphoinositide-3-kinase, catalytic, gamma polypeptide
File:PBB Protein PIK3CG image.jpg PDB rendering based on 17eu.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1e7u​, 1e7v​, 1e8w​, 1e8x​, 1e8y​, 1e8z​, 1e90​, 1he8​, 2a4z​, 2a5u​, 2chw​, 2chx​, 2chz​
Identifiers
Symbols	PIK3CG ; PI3K; PI3CG; PI3Kgamma; PIK3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68269
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PIK3CG 206370 at tn.png
File:PBB GE PIK3CG 206369 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Phosphoinositide-3-kinase, catalytic, gamma polypeptide, also known as PIK3CG, is a human gene.

This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.

See also

• Class I PI 3-kinases
• p87PIKAP

Further reading

• Alloatti G, Montrucchio G, Lembo G, Hirsch E (2004). "Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease". Biochem. Soc. Trans. 32 (Pt 2): 383–6. doi:10.1042/ . PMID 15046613.CS1 maint: Multiple names: authors list (link)
• Rommel C, Camps M, Ji H (2007). "PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?". Nat. Rev. Immunol. 7 (3): 191–201. doi:10.1038/nri2036. PMID 17290298.CS1 maint: Multiple names: authors list (link)