DDB2

Damage-specific DNA binding protein 2, 48kDa
Identifiers
Symbols	DDB2 ; FLJ34321
External IDs	Template:OMIM5 Template:MGI HomoloGene: 83
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Damage-specific DNA binding protein 2, 48kDa, also known as DDB2, is a human gene.

DDB2 is the smaller subunit of a heterodimeric protein implicated in the etiology of xeroderma pigmentosum group E. This subunit appears to be required for DNA binding.

Further reading

• El-Deiry WS (2003). "Transactivation of repair genes by BRCA1". Cancer Biol. Ther. 1 (5): 490–1. PMID 12496474.
• Qian YW, Wang YC, Hollingsworth RE; et al. (1993). "A retinoblastoma-binding protein related to a negative regulator of Ras in yeast". Nature. 364 (6438): 648–52. doi:10.1038/364648a0. PMID 8350924.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Keeney S, Chang GJ, Linn S (1993). "Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E.". J. Biol. Chem. 268 (28): 21293–300. PMID 8407967.CS1 maint: Multiple names: authors list (link)
• Dualan R, Brody T, Keeney S; et al. (1996). "Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein". Genomics. 29 (1): 62–9. doi:10.1006/geno.1995.1215. PMID 8530102.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Taunton J, Hassig CA, Schreiber SL (1996). "A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p". Science. 272 (5260): 408–11. PMID 8602529.CS1 maint: Multiple names: authors list (link)
• Nichols AF, Ong P, Linn S (1996). "Mutations specific to the xeroderma pigmentosum group E Ddb- phenotype". J. Biol. Chem. 271 (40): 24317–20. PMID 8798680.CS1 maint: Multiple names: authors list (link)
• Hayes S, Shiyanov P, Chen X, Raychaudhuri P (1998). "DDB, a putative DNA repair protein, can function as a transcriptional partner of E2F1". Mol. Cell. Biol. 18 (1): 240–9. PMID 9418871.CS1 maint: Multiple names: authors list (link)
• Martinez E, Palhan VB, Tjernberg A; et al. (2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Mol. Cell. Biol. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMID 11564863.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen X, Zhang Y, Douglas L, Zhou P (2002). "UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation". J. Biol. Chem. 276 (51): 48175–82. doi:10.1074/jbc.M106808200. PMID 11673459.CS1 maint: Multiple names: authors list (link)
• Sun NK, Kamarajan P, Huang H, Chao CC (2002). "Restoration of UV sensitivity in UV-resistant HeLa cells by antisense-mediated depletion of damaged DNA-binding protein 2 (DDB2)". FEBS Lett. 512 (1–3): 168–72. PMID 11852074.CS1 maint: Multiple names: authors list (link)
• Tan T, Chu G (2002). "p53 Binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice". Mol. Cell. Biol. 22 (10): 3247–54. PMID 11971958.
• Rapić-Otrin V, McLenigan MP, Bisi DC; et al. (2002). "Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation". Nucleic Acids Res. 30 (11): 2588–98. PMID 12034848.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bergametti F, Sitterlin D, Transy C (2002). "Turnover of hepatitis B virus X protein is regulated by damaged DNA-binding complex". J. Virol. 76 (13): 6495–501. PMID 12050362.CS1 maint: Multiple names: authors list (link)
• Bontron S, Lin-Marq N, Strubin M (2002). "Hepatitis B virus X protein associated with UV-DDB1 induces cell death in the nucleus and is functionally antagonized by UV-DDB2". J. Biol. Chem. 277 (41): 38847–54. doi:10.1074/jbc.M205722200. PMID 12151405.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sun NK, Lu HP, Chao CC (2003). "Overexpression of damaged-DNA-binding protein 2 (DDB2) potentiates UV resistance in hamster V79 cells". Chang Gung medical journal. 25 (11): 723–33. PMID 12553360.CS1 maint: Multiple names: authors list (link)
• Groisman R, Polanowska J, Kuraoka I; et al. (2003). "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage". Cell. 113 (3): 357–67. PMID 12732143.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rapić-Otrin V, Navazza V, Nardo T; et al. (2004). "True XP group E patients have a defective UV-damaged DNA binding protein complex and mutations in DDB2 which reveal the functional domains of its p48 product". Hum. Mol. Genet. 12 (13): 1507–22. PMID 12812979.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fitch ME, Nakajima S, Yasui A, Ford JM (2004). "In vivo recruitment of XPC to UV-induced cyclobutane pyrimidine dimers by the DDB2 gene product". J. Biol. Chem. 278 (47): 46906–10. doi:10.1074/jbc.M307254200. PMID 12944386.CS1 maint: Multiple names: authors list (link)