Legius syndrome

Jump to navigation Jump to search
Legius syndrome
DiseasesDB 34916

WikiDoc Resources for Legius syndrome

Articles

Most recent articles on Legius syndrome

Most cited articles on Legius syndrome

Review articles on Legius syndrome

Articles on Legius syndrome in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Legius syndrome

Images of Legius syndrome

Photos of Legius syndrome

Podcasts & MP3s on Legius syndrome

Videos on Legius syndrome

Evidence Based Medicine

Cochrane Collaboration on Legius syndrome

Bandolier on Legius syndrome

TRIP on Legius syndrome

Clinical Trials

Ongoing Trials on Legius syndrome at Clinical Trials.gov

Trial results on Legius syndrome

Clinical Trials on Legius syndrome at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Legius syndrome

NICE Guidance on Legius syndrome

NHS PRODIGY Guidance

FDA on Legius syndrome

CDC on Legius syndrome

Books

Books on Legius syndrome

News

Legius syndrome in the news

Be alerted to news on Legius syndrome

News trends on Legius syndrome

Commentary

Blogs on Legius syndrome

Definitions

Definitions of Legius syndrome

Patient Resources / Community

Patient resources on Legius syndrome

Discussion groups on Legius syndrome

Patient Handouts on Legius syndrome

Directions to Hospitals Treating Legius syndrome

Risk calculators and risk factors for Legius syndrome

Healthcare Provider Resources

Symptoms of Legius syndrome

Causes & Risk Factors for Legius syndrome

Diagnostic studies for Legius syndrome

Treatment of Legius syndrome

Continuing Medical Education (CME)

CME Programs on Legius syndrome

International

Legius syndrome en Espanol

Legius syndrome en Francais

Business

Legius syndrome in the Marketplace

Patents on Legius syndrome

Experimental / Informatics

List of terms related to Legius syndrome

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[3]

Synonyms and keywords: Neurofibromatosis, type 1-like syndrome

Overview

Legius syndrome (LS) is an autosomal dominant condition characterized by cafe au lait spots.[1]

Historical Perspective

  • It was first described in 2007 and is often mistaken for Neurofibromatosis type I (NF-1).
  • The syndrome is named after Eric Legius, Professor at the Katholieke Universiteit Leuven|Catholic University of Leuven.

Pathophysiology

Genetics

It is caused by mutations in the SPRED1 gene.[2][3][4]

Differentiating Legius syndrome from other Diseases

Neurofibromatosis type 1

  • The similarity of symptoms stem from the fact that the different genes affected in the two syndromes code for proteins that carry out a similar task in the same reaction pathway.
  • A genetic test is often the only way to make sure a person has Legius syndrome and not NF-1.
  • Because of this difference, Legius syndrome is often seen as the less severe of the two syndromes.

Diagnosis

Symptoms

Physical Examination

Skin

Head

Neurologic

Other

Other Diagnostic Studies

References


Template:WS