Quinapril overdose
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overdosage topics
Manifestations
Lab determination
Physiological maneuvers
Hemodialysis/peritoneal dialysis
Manifestations
No specific information is available on the treatment of overdosage with Quinapril. The most likely clinical manifestation would be symptoms attributable to severe hypotension. Return to top
Lab determination
Laboratory determinations of serum levels of Quinapril and its metabolites are not widely available, and such determinations have, in any event, no established role in the management of Quinapril overdose. Return to top
Physiological maneuvers
No data are available to suggest physiological maneuvers (eg, maneuvers to change pH of the urine) that might accelerate elimination of Quinapril and its metabolites. Return to top
Hemodialysis/peritoneal dialysis
Hemodialysis and peritoneal dialysis have little effect on the elimination of Quinapril and Quinaprilat. Angiotensin II could presumably serve as a specific antagonist-antidote in the setting of Quinapril overdose, but angiotensin II is essentially unavailable outside of scattered research facilities. Because the hypotensive effect of Quinapril is achieved through vasodilation and effective hypovolemia, it is reasonable to treat Quinapril overdose by infusion of normal saline solution. Return to top
Adapted from the FDA Package Insert.