PURSUIT risk score
Definition and History
The PURSUIT (Platelet glycoprotein IIb/IIIa in Unstable angina: Receptor Suppression Using Integrilin Therapy) risk score was developed in a randomized clinical trial which recruited 9,461 patients and compared eptifibatide (Integrilin) to placebo in the management of Unstable Angina (UA) or Non-ST elevation Myocardial Infarction (NSTEMI).
Function
- By using multivariate regression analysis, the investigators established seven risk predictors for death and myocardial infarction (MI) in patients with acute coronary syndromes.
- Five of these risk factors were then combined into a scoring system:
- Higher age
- Sex
- Worst Canadian Cardiovascular Society (CCS) class of angina
- Signs of heart failure
- ST-segment depression on the index ECG
- Each of these elements is scored accordingly, resulting in a score ranging 1 - 18.
| Elements | Entry | Score |
|---|---|---|
| Age |
|
|
| Sex | ||
| Worst CCS class past 6 weeks | ||
| Signs of heart failure | ||
| ST depression on ECG |