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Lipomatous tumor Age of onset Gender preponderance Location Clinical features Diagnostic feature(s) Other features
Angiolipoma
  • Second and third decades of life
  • Male > female
  • More commonly seen in forearm
  • May also affect trunk and upper arm
  • Subcutaneous nodule
  • Tender to palpation
  • Less than 2 cm
  • Encapsulated, yellow nodules with a reddish tinge
  • A combination of fatty tissue and vascular channels
  • Fibrin thrombi is present in vascular channels (characteristic finding)
  • Benign
Myolipoma
  • Fifth and sixth decades of life
  • Female > male
  • More commonly seen in retroperitoneum, abdomen, pelvis, inguinal region, or abdominal wall
  • May also affect extremities
  • Subcutaneous mass which may also engage superficial muscular fascia
  • Size differs depending on the location
  • Partially encapsulated mass with partially yellow-white cut surface
  • A combination of mature adipocytes and sheets of well-differentiated smooth muscle
  • No nuclear atypia
  • Sieve-like appearance at low magnification (due to interspersed location of smooth muscle component)
  • Benign
  • It is usually large and located in the deep soft tissues
Myelolipoma
  • Fifth decade of life
  • Male = female
  • More commonly seen in adrenal glands
  • Other possible locations include:
  • thoracic,  retroperitoneum  and presacral region,  mediastinum,  liver,  and bone
  • Usually asymptomatic
  • May cause abdominal pain, nausea, and constipation (depending on the location and size)
  • Uncommonly, may cause retro-peritoneal hemorrhage
  • 3 to 7 cm
  • A combination of bone marrow elements and adipose tissue in varying proportions
  • May show myxoid changes
  • Well-circumscribed radiolucent mass in radiologic imaging
  • May have hromonal activity
Spindle Cell/Pleomorphic Lipoma
  • Fifth to seventh decades of life
  • Male > female
  • More commonly seen in posterior neck, shoulder, and back
  • It is also reported in oral cavity
  • Subcutaneous nodule with firm consistency
  • Slowly growing and painless
  • Mostly between 3 to 5 cm
  • Similar to ordinary lipoma
  • A combination of mature fat cells and spindle cell or pleomorphic elements
  • Lipomatous component may vary in amount
  • Immunohistochemically positive for CD34
  • Benign
Chondroid Lipoma
  • Third or fourth decade of life
  • Female > male
  • More commonly seen in limbs and limb girdles
  • May also involves trunk, and the head and neck region, particularly the oral cavity
  • Slowly growing painless mass
  • Sizes ranges from 1 to 11 cm
  • Encapsulated tumor with a yellow, white, or pink-tan cut surface
  • A combination of mature adipocytes in association with nests of vacuolated cells in a myxochondroid or hyalinized fibrous background
  • Heterogeneous soft tissue mass in radiologic imaging
  • Benign


Example #1

The patient presented with S.O.B. one year after hysterectomy for a leiomyomatous uterus.