Sideroblastic anemia epidemiology and demographics
Age
- Patients of all age groups may develop sideroblastic anemia.
- Congenital X-linked sideroblastic anemia due to ALAS mutation can remain undiagnosed and then present late in the fourth to eighth decades of life.
- The incidence of acquired sideroblastic anemia increases with age; the median age at diagnosis is 74 years.
- Chronic sideroblastic anemia is usually first diagnosed among middle and older age group.[1]
Race
- There is no racial predilection to sideroblastic anemia.
Gender
- Males are more commonly affected than females in X-linked recessive types of sideroblastic anemia.
- A female would have to inherit 1 abnormal chromosome from each parent to acquire the sideroblastic anemia.
- Primary acquired sideroblastic anemia was found in 60.4% male and 39.6% female.[1]
Region
- Sideroblastic anemia is more prevalent in European countries,in peadiatric population.
Epidemiology and Demographics
Hereditary sideroblastic anemia, being sex-linked, primarily affects males.
• Primary acquired sideroblastic anemia is usually a disease of the elderly.In 25 bone marrow biopsies of children younger than 13 years from Atlanta, Georgia (United States), with anemia, the prevalence of ringed sideroblasts was 8%. [50]
In France, the prevalence of ringed sideroblasts was 57% in patients with primary MDS. [51] In the United Kingdom, amongst healthy volunteers undergoing bone marrow biopsy, siderotic granules (not ring sideroblasts) were present in 29% of men and 19% of women. [52]
Although usually manifested in childhood, congenital X-linked sideroblastic anemia due to ALAS mutation can remain undiagnosed and then present late in the fourth to eighth decades of life. [53, 54] The median age of occurrence of primary acquired sideroblastic anemia is 74 years. [55]
X-linked recessive types of sideroblastic anemia occur more commonly in males. A female would have to inherit 1 abnormal chromosome from each parent to acquire the disease. Progesterone and pregnancy have been reported to induce relapse of sideroblastic anemia. [
References
- ↑ 1.0 1.1 Hadnagy C (1991). "Primary acquired sideroblastic anemia and myelodysplastic syndrome from a geriatric point of view". Z Gerontol. 24 (2): 105–9. PMID 1877285.