Sjögren's syndrome natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Natural History

Natural History

• The symptoms of (disease name) usually develop in the first/ second/ third decade of life, and start with symptoms such as ___.
• The symptoms of (disease name) typically develop ___ years after exposure to ___.
• If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].

Complications

• Common complications of Sjögren's syndrome include:
  • Dental cavities
  • Yeast infections
  • Blurred vision and corneal damage
  • Pneumonia
  • Bronchitis
  • Lymphoma
  • peripheral neuropathy
  • Myelitis
  • Optic neuritis

Prognosis

• Prognosis is generally good and presence of low complement level is associated with a particularly poor prognosis among patients with Sjögren's syndrome.
• Primary Sjögren syndrome is associated with lower cardiovascular risk factors complication such as myocardial infraction and stroke.