Peptic ulcer historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ;Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Overview
Historical Perspective
In 1997, the Centers for Disease Control and Prevention, with other government agencies, academic institutions, and industry, launched a national education campaign to inform health care providers and consumers about the link between H. pylori and ulcers. This campaign reinforced the news that ulcers are a curable infection, and the fact that health can be greatly improved and money saved by disseminating information about H. pylori.[1]
Helicobacter pylori was rediscovered in 1982 by two Australian scientists Robin Warren and Barry Marshall[2]. In their original paper, Warren and Marshall contended that most stomach ulcers and gastritis were caused by colonization with this bacterium, not by stress or spicy food as had been assumed before.[3]
The H. pylori hypothesis was poorly received, so in an act of self-experimentation Marshall drank a petri-dish containing a culture of organisms extracted from a patient and soon developed gastritis. His symptoms disappeared after two weeks, but he took antibiotics to kill the remaining bacteria at the urging of his wife, since halitosis is one of the symptoms of infection.[4] This experiment was published in 1984 in the Australian Medical Journal and is among the most cited articles from the journal.
In 2005, the Karolinska Institute in Stockholm awarded the Nobel Prize in Physiology or Medicine to Dr. Marshall and his long-time collaborator Dr. Warren "for their discovery of the bacterium Helicobacter pylori and its role in gastritis and peptic ulcer disease". Professor Marshall continues research related to H. pylori and runs a molecular biology lab at UWA in Perth, Western Australia.
- Gastric ulcer was first discovered by Goldstein, a [nationality + occupation], in [year]/during/following [event].
- Spiral-shaped microorganism described by Polish clinical researcher Professor W.Jaworski at Cracow Jagiellonian University 100 years ago but it was confirmed in the animal by G.Bizzazero.In late 1970, J.R Warren, a pathologist in Perth, Australia found the appearance of spiral bacteria overlying gastric mucosa.
In 1982 Warren and B.J marshall cultured the organism and demonstrate a strong association between Helicobacter pylori and inflammation of gastric mucosa ,it is not due to spicy food and stress [5][6] 1994 A National Institutes of Health Consensus Development Conference concludes that there is a strong association between H. pylori and ulcer disease, and recommends that ulcer patients with H. pylori infection be treated with antibiotics.
Overview
Historical Perspective
Discovery
- Peptic ulcer disease was first discovered by Asklepios , a [nationality + occupation], in [year]/during/following [event].
- Spiral-shaped microorganism described by Polish clinical researcher Professor W.Jaworski at Cracow Jagiellonian University 100 years ago but it was confirmed in the animal by G.Bizzazero.In late 1970, J.R Warren, a pathologist in Perth, Australia found the appearance of spiral bacteria overlying gastric mucosa.[5]
- William Brinton’s 1857 book on ulcer of the stomach where he describe his extensive experiences with ulcer disease and gastric cancer.
- The association between Helicobacter pylori and peptic ulcer disease was made in 1982 by Warren and B.J marshall.They contended that most stomach ulcers and gastritis were caused by colonization with this bacterium, not by stress or spicy food as had been assumed before.[7][5][6]
- In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].
A National Institutes of Health Consensus Development Conference concludes that there is a strong association between H. pylori and ulcer disease, and recommends that ulcer patients with H. pylori infection be treated with antibiotics.
Outbreaks
- There have been several outbreaks of [disease name], which are summarized below:
Landmark Events in the Development of Treatment Strategies
- In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].
Impact on Cultural History
Famous Cases
- The following are a few famous cases of disease name:
References
- ↑ Ulcer, Diagnosis and Treatment - CDC Bacterial, Mycotic Diseases
- ↑ Marshall BJ (1983). "Unidentified curved bacillus on gastric epithelium in active chronic gastritis". Lancet. 1 (8336): 1273–1275. PMID 6134060.
- ↑ Marshall BJ, Warren JR (1984). "Unidentified curved bacilli in the stomach patients with gastritis and peptic ulceration". Lancet. 1 (8390): 1311–1315. PMID 6145023.
- ↑ "Research Enterprise, The 2005 Nobel Prize in Physiology or Medicine". Retrieved 2007-08-26.
- ↑ 5.0 5.1 5.2 Konturek JW (2003). "Discovery by Jaworski of Helicobacter pylori and its pathogenetic role in peptic ulcer, gastritis and gastric cancer". J. Physiol. Pharmacol. 54 Suppl 3: 23–41. PMID 15075463.
- ↑ 6.0 6.1 "Home | CDC Ulcer".
- ↑ Marshall BJ, Warren JR (1984). "Unidentified curved bacilli in the stomach patients with gastritis and peptic ulceration". Lancet. 1 (8390): 1311–1315. PMID 6145023.