Hirschsprung's disease risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Younes M.B.B.CH [2]

Overview

The most potent risk factor for Hirschsprung's disease is a strong family history (multiple family members afflicted). Other risk factors include a family history of long segment disease and the proband being female.

Risk factors

The most potent risk factors for developing Hirschsprung's disease include:

  • Having multiple family members affected by the disease[1]
  • Family history of the long segment variant of the disease
  • Male gender[2]

References

  1. Swenson O (2002). "Hirschsprung's disease: a review". Pediatrics. 109 (5): 914–8. PMID 11986456.
  2. Passarge E (1967). "The genetics of Hirschsprung's disease. Evidence for heterogeneous etiology and a study of sixty-three families". N. Engl. J. Med. 276 (3): 138–43. doi:10.1056/NEJM196701192760303. PMID 4224912.