Syndrome of inappropriate antidiuretic hormone laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]


Overview

The lab findings which help in diagnosis of SIADH are serum electrolytes (especially sodium), creatinine, BUN, serum uric acid, serum cortisol, plasma ADH level. Urine osmolality,urine sodium level and GFR are also of diagnostic significance.

Laboratory Findings

Lab findings consistent with the diagnosis of SIADH are;

  • Decreased serum sodium (<135 meq/l)
  • Decreased serum osmolality(<280mosm/kg)
  • Low BUN levels
  • Low albumin levels
  • Low uric acid
  • Normal Creatinine
  • Normal thyroid hormones
  • Normal cortisol
  • Increased GFR
  • Increased plasma ADH levels[1]

References

  1. Shimamoto K, Murase T, Yamaji T (1976). "A heterologous radioimmunoassay for arginine vasopressin". J. Lab. Clin. Med. 87 (2): 338–44. PMID 1245796.


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