Hereditary nonpolyposis colorectal cancer risk factors

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Overview

The most potent risk factor in the development of Hereditary nonpolyposis colorectal cancer is gene mutations caused by defective DNA mismatch repair. There are no other risk factors associated with this condition.

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Genetics

The 4 main MMR genes associated with Lynch syndrome are MLH1, MSH2, MSH6 and PMS2. Most mutations (90%) that cause Lynch syndrome are found in the MLH1 or MSH2 genes. The other 2 genes, MSH6 and PMS2, and possibly others, account for the other 10% of mutations.[1]

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