Radium chloride
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alberto Plate [2]
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Overview
Radium chloride is {{{aOrAn}}} {{{drugClass}}} that is FDA approved for the treatment of patients with castration-resistant prostate cancer, symptomatic bone metastases and no known visceral metastatic disease. Common adverse reactions include nausea, diarrhea, vomiting, and peripheral edema.
Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
There is limited information regarding Radium chloride FDA-Labeled Indications and Dosage (Adult) in the drug label.
Off-Label Use and Dosage (Adult)
Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Radium chloride in adult patients.
Non–Guideline-Supported Use
There is limited information regarding Off-Label Non–Guideline-Supported Use of Radium chloride in adult patients.
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
There is limited information regarding Radium chloride FDA-Labeled Indications and Dosage (Pediatric) in the drug label.
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Radium chloride in pediatric patients.
Non–Guideline-Supported Use
There is limited information regarding Off-Label Non–Guideline-Supported Use of Radium chloride in pediatric patients.
Contraindications
There is limited information regarding Radium chloride Contraindications in the drug label.
Warnings
There is limited information regarding Radium chloride Warnings' in the drug label.
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Radium chloride Clinical Trials Experience in the drug label.
Postmarketing Experience
There is limited information regarding Radium chloride Postmarketing Experience in the drug label.
Drug Interactions
There is limited information regarding Radium chloride Drug Interactions in the drug label.
Use in Specific Populations
Pregnancy
Pregnancy Category (FDA):
There is no FDA guidance on usage of Radium chloride in women who are pregnant.
Pregnancy Category (AUS):
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Radium chloride in women who are pregnant.
Labor and Delivery
There is no FDA guidance on use of Radium chloride during labor and delivery.
Nursing Mothers
There is no FDA guidance on the use of Radium chloride in women who are nursing.
Pediatric Use
There is no FDA guidance on the use of Radium chloride in pediatric settings.
Geriatic Use
There is no FDA guidance on the use of Radium chloride in geriatric settings.
Gender
There is no FDA guidance on the use of Radium chloride with respect to specific gender populations.
Race
There is no FDA guidance on the use of Radium chloride with respect to specific racial populations.
Renal Impairment
There is no FDA guidance on the use of Radium chloride in patients with renal impairment.
Hepatic Impairment
There is no FDA guidance on the use of Radium chloride in patients with hepatic impairment.
Females of Reproductive Potential and Males
There is no FDA guidance on the use of Radium chloride in women of reproductive potentials and males.
Immunocompromised Patients
There is no FDA guidance one the use of Radium chloride in patients who are immunocompromised.
Administration and Monitoring
Administration
There is limited information regarding Radium chloride Administration in the drug label.
Monitoring
There is limited information regarding Radium chloride Monitoring in the drug label.
IV Compatibility
There is limited information regarding the compatibility of Radium chloride and IV administrations.
Overdosage
There is limited information regarding Radium chloride overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.
Pharmacology
There is limited information regarding Radium chloride Pharmacology in the drug label.
Mechanism of Action
There is limited information regarding Radium chloride Mechanism of Action in the drug label.
Structure
There is limited information regarding Radium chloride Structure in the drug label.
Pharmacodynamics
There is limited information regarding Radium chloride Pharmacodynamics in the drug label.
Pharmacokinetics
There is limited information regarding Radium chloride Pharmacokinetics in the drug label.
Nonclinical Toxicology
There is limited information regarding Radium chloride Nonclinical Toxicology in the drug label.
Clinical Studies
There is limited information regarding Radium chloride Clinical Studies in the drug label.
How Supplied
There is limited information regarding Radium chloride How Supplied in the drug label.
Storage
There is limited information regarding Radium chloride Storage in the drug label.
Images
Drug Images
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Package and Label Display Panel
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Patient Counseling Information
There is limited information regarding Radium chloride Patient Counseling Information in the drug label.
Precautions with Alcohol
Alcohol-Radium chloride interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
Brand Names
There is limited information regarding Radium chloride Brand Names in the drug label.
Look-Alike Drug Names
There is limited information regarding Radium chloride Look-Alike Drug Names in the drug label.
Drug Shortage Status
Price
References
The contents of this FDA label are provided by the National Library of Medicine.
Template:Chembox new Radium chloride, RaCl2, was the first radium compound to be prepared in a pure state and was the basis of Marie Curie's original separation of radium from barium.[1] The first preparation of radium metal was by the electrolysis of a solution of radium chloride using a mercury cathode.
Preparation
Radium chloride crystallises from solution as the dihydrate. It may be dehydrated by heating to 100 °C in air for one hour followed by 5½ hours at 520 °C under argon.[2] If the presence of other anions is suspected, the dehydration may be effectuated by fusion under hydrogen chloride.[3]
Properties
Radium chloride is a white solid with a blue-green luminescence, especially when heated. It is less soluble in water than other alkaline earth metal chlorides, a fact which is used in the first stages of the separation of radium from barium by fractional crystallization. It is only sparingly soluble in azeotropic hydrochloric acid and virtually insoluble in concentrated hydrochloric acid.[4]
Gaseous radium chloride exists as RaCl2 molecules, as with other alkaline earth metal halides. The gas shows strong absorptions in the visible spectrum at 676.3 nm and 649.8 nm (red): the dissociation energy of the radium–chlorine bond is estimated as 2.9 eV,[5] and its length as 292 pm.[6]
Uses
Radium chloride is still used for the initial stages of the separation of radium from barium during the extraction of radium from pitchblende. The large quantities of material involved (tonnes of ore for milligrams of radium) favour this less costly (but less efficient) method over those based on radium bromide or radium chromate (used for the later stages of the separation).
Sources
- Gmelins Handbuch der anorganischen Chemie (8. Aufl.), Berlin:Verlag Chemie, 1928, pp. 60–61.
- Gmelin Handbuch der anorganischen Chemie (8. Aufl. 2. Erg.-Bd.), Berlin:Springer, 1977, pp. 362–64.
References
- ↑ Curie, M.; Debierne, A. (1910). C. R. Hebd. Acad. Sci. Paris 151:523–25.
- ↑ Weigel, F.; Trinkl, A. (1968). Radiochim. Acta 9:36–41.
- ↑ Hönigschmid, O.; Sachtleben, R. (1934). Z. Anorg. Allg. Chem. 221:65–82.
- ↑ Erbacher, O. (1930). Ber. Dtsch. Chem. Ges. 63:141–56.
- ↑ Lagerqvist, A. (1953). Arkiv Fisik 6:141–42.
- ↑ Karapet'yants, M. Kh.; Ch'ing, Ling-T'ing (1960). Zh. Strukt. Khim. 1:277–85; J. Struct. Chem. (USSR) 1:255–63.