DDX19B

Revision as of 10:27, 14 February 2018 by en>R'n'B (Disambiguating links to Nucleus (link changed to Cell nucleus) using DisamAssist.)
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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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ATP-dependent RNA helicase DDX19B is an enzyme that in humans is encoded by the DDX19B gene.[1][2]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.[2]

References

  1. Schmitt C, von Kobbe C, Bachi A, Pante N, Rodrigues JP, Boscheron C, Rigaut G, Wilm M, Seraphin B, Carmo-Fonseca M, Izaurralde E (Sep 1999). "Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p". EMBO J. 18 (15): 4332–47. doi:10.1093/emboj/18.15.4332. PMC 1171509. PMID 10428971.
  2. 2.0 2.1 "Entrez Gene: DDX19B DEAD (Asp-Glu-Ala-As) box polypeptide 19B".

Further reading