PTPN2

Protein tyrosine phosphatase, non-receptor type 2
File:PBB Protein PTPN2 image.jpg PDB rendering based on 1l8k.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1l8k​
Identifiers
Symbols	PTPN2 ; PTPT; TC-PTP; TCELLPTP; TCPTP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7497
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein tyrosine phosphatase, non-receptor type 2, also known as PTPN2, is a human gene.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported.

Further reading

• Mosinger B, Tillmann U, Westphal H, Tremblay ML (1992). "Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase". Proc. Natl. Acad. Sci. U.S.A. 89 (2): 499–503. PMID 1731319.CS1 maint: Multiple names: authors list (link)
• Swarup G, Kamatkar S, Radha V, Rema V (1991). "Molecular cloning and expression of a protein-tyrosine phosphatase showing homology with transcription factors Fos and Jun". FEBS Lett. 280 (1): 65–9. PMID 1849097.CS1 maint: Multiple names: authors list (link)
• Brown-Shimer S, Johnson KA, Lawrence JB; et al. (1990). "Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B". Proc. Natl. Acad. Sci. U.S.A. 87 (13): 5148–52. PMID 2164224.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cool DE, Tonks NK, Charbonneau H; et al. (1989). "cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family". Proc. Natl. Acad. Sci. U.S.A. 86 (14): 5257–61. PMID 2546150.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lorenzen JA, Dadabay CY, Fischer EH (1995). "COOH-terminal sequence motifs target the T cell protein tyrosine phosphatase to the ER and nucleus". J. Cell Biol. 131 (3): 631–43. PMID 7593185.CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Johnson CV, Cool DE, Glaccum MB; et al. (1993). "Isolation and mapping of human T-cell protein tyrosine phosphatase sequences: localization of genes and pseudogenes discriminated using fluorescence hybridization with genomic versus cDNA probes". Genomics. 16 (3): 619–29. doi:10.1006/geno.1993.1239. PMID 8325634.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tiganis T, Flint AJ, Adam SA, Tonks NK (1997). "Association of the T-cell protein tyrosine phosphatase with nuclear import factor p97". J. Biol. Chem. 272 (34): 21548–57. PMID 9261175.CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tiganis T, Bennett AM, Ravichandran KS, Tonks NK (1998). "Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase". Mol. Cell. Biol. 18 (3): 1622–34. PMID 9488479.CS1 maint: Multiple names: authors list (link)
• Tiganis T, Kemp BE, Tonks NK (1999). "The protein-tyrosine phosphatase TCPTP regulates epidermal growth factor receptor-mediated and phosphatidylinositol 3-kinase-dependent signaling". J. Biol. Chem. 274 (39): 27768–75. PMID 10488121.CS1 maint: Multiple names: authors list (link)
• Aoki N, Matsuda T (2002). "A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus". Mol. Endocrinol. 16 (1): 58–69. PMID 11773439.
• Iversen LF, Moller KB, Pedersen AK; et al. (2002). "Structure determination of T cell protein-tyrosine phosphatase". J. Biol. Chem. 277 (22): 19982–90. doi:10.1074/jbc.M200567200. PMID 11907034.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Simoncic PD, Lee-Loy A, Barber DL; et al. (2002). "The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3". Curr. Biol. 12 (6): 446–53. PMID 11909529.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• ten Hoeve J, de Jesus Ibarra-Sanchez M, Fu Y; et al. (2002). "Identification of a nuclear Stat1 protein tyrosine phosphatase". Mol. Cell. Biol. 22 (16): 5662–8. PMID 12138178.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhu W, Mustelin T, David M (2002). "Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase". J. Biol. Chem. 277 (39): 35787–90. doi:10.1074/jbc.C200346200. PMID 12171910.CS1 maint: Multiple names: authors list (link)
• Yamamoto T, Sekine Y, Kashima K; et al. (2002). "The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation". Biochem. Biophys. Res. Commun. 297 (4): 811–7. PMID 12359225.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gupta S, Radha V, Sudhakar Ch, Swarup G (2003). "A nuclear protein tyrosine phosphatase activates p53 and induces caspase-1-dependent apoptosis". FEBS Lett. 532 (1–2): 61–6. PMID 12459463.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Galic S, Klingler-Hoffmann M, Fodero-Tavoletti MT; et al. (2003). "Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP". Mol. Cell. Biol. 23 (6): 2096–108. PMID 12612081.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)