Histone deacetylase 5

Histone deacetylase 5
Identifiers
Symbols	HDAC5 ; FLJ90614; HD5; NY-CO-9
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3995
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Histone deacetylase 5, also known as HDAC5, is a human gene.

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.

See also

• Histone deacetylase

Further reading

• Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. PMID 12168954.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Verdin E, Dequiedt F, Kasler HG (2003). "Class II histone deacetylases: versatile regulators". Trends Genet. 19 (5): 286–93. PMID 12711221.CS1 maint: Multiple names: authors list (link)
• Scanlan MJ, Chen YT, Williamson B; et al. (1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". Int. J. Cancer. 76 (5): 652–8. PMID 9610721.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase T, Ishikawa K, Miyajima N; et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. PMID 9628581.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grozinger CM, Hassig CA, Schreiber SL (1999). "Three proteins define a class of human histone deacetylases related to yeast Hda1p". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4868–73. PMID 10220385.CS1 maint: Multiple names: authors list (link)
• Huang EY, Zhang J, Miska EA; et al. (2000). "Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway". Genes Dev. 14 (1): 45–54. PMID 10640275.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lemercier C, Verdel A, Galloo B; et al. (2000). "mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity". J. Biol. Chem. 275 (20): 15594–9. doi:10.1074/jbc.M908437199. PMID 10748098.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grozinger CM, Schreiber SL (2000). "Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7835–40. doi:10.1073/pnas.140199597. PMID 10869435.
• Huynh KD, Fischle W, Verdin E, Bardwell VJ (2000). "BCoR, a novel corepressor involved in BCL-6 repression". Genes Dev. 14 (14): 1810–23. PMID 10898795.CS1 maint: Multiple names: authors list (link)
• Mahlknecht U, Schnittger S, Ottmann OG; et al. (2000). "Chromosomal organization and localization of the human histone deacetylase 5 gene (HDAC5)". Biochim. Biophys. Acta. 1493 (3): 342–8. PMID 11018260.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang CL, McKinsey TA, Lu JR, Olson EN (2001). "Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor". J. Biol. Chem. 276 (1): 35–9. doi:10.1074/jbc.M007364200. PMID 11022042.CS1 maint: Multiple names: authors list (link)
• McKinsey TA, Zhang CL, Lu J, Olson EN (2000). "Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation". Nature. 408 (6808): 106–11. doi:10.1038/35040593. PMID 11081517.CS1 maint: Multiple names: authors list (link)
• McKinsey TA, Zhang CL, Olson EN (2001). "Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14400–5. doi:10.1073/pnas.260501497. PMID 11114197.CS1 maint: Multiple names: authors list (link)
• Fischle W, Dequiedt F, Fillion M; et al. (2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". J. Biol. Chem. 276 (38): 35826–35. doi:10.1074/jbc.M104935200. PMID 11466315.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McKinsey TA, Zhang CL, Olson EN (2001). "Identification of a signal-responsive nuclear export sequence in class II histone deacetylases". Mol. Cell. Biol. 21 (18): 6312–21. PMID 11509672.CS1 maint: Multiple names: authors list (link)
• Ozawa Y, Towatari M, Tsuzuki S; et al. (2001). "Histone deacetylase 3 associates with and represses the transcription factor GATA-2". Blood. 98 (7): 2116–23. PMID 11567998.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Potter GB, Beaudoin GM, DeRenzo CL; et al. (2001). "The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor". Genes Dev. 15 (20): 2687–701. doi:10.1101/gad.916701. PMID 11641275.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fischle W, Dequiedt F, Hendzel MJ; et al. (2002). "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". Mol. Cell. 9 (1): 45–57. PMID 11804585.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lemercier C, Brocard MP, Puvion-Dutilleul F; et al. (2002). "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor". J. Biol. Chem. 277 (24): 22045–52. doi:10.1074/jbc.M201736200. PMID 11929873.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huang Y, Tan M, Gosink M; et al. (2002). "Histone deacetylase 5 is not a p53 target gene, but its overexpression inhibits tumor cell growth and induces apoptosis". Cancer Res. 62 (10): 2913–22. PMID 12019172.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• HDAC5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain. Template:WikiDoc Sources