Ticlopidine: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Changed protection level for "Ticlopidine" ([Edit=Allow only autoconfirmed users] (expires 23:55, 12 February 2014 (UTC)) [Move=Allow only autoconfirmed users] (expires 23:55, 12 February 2014 (UTC))))
No edit summary
Line 1: Line 1:
{{drugbox
| IUPAC_name = 3-[(2-chlorophenyl)methyl] -7-thia-3-azabicyclo[4.3.0] nona-8,10-diene
| image = Ticlopidine_svg.png
| CAS_number = 55142-85-3
| ATC_prefix = B01
| ATC_suffix = AC05
| ATC_supplemental =
| PubChem = 5472
| DrugBank = APRD01257
| C = 14 | H = 14 | Cl = 1 | N = 1 | S = 1
| molecular_weight = 263.786 g/mol
| bioavailability = >80%
| protein_bound = 98%
| metabolism = [[Liver|Hepatic]]
| elimination_half-life = *12 hours (single dose)
*4 to 5 days (after repeated dosing)
| excretion = [[Kidney|Renal]] and fecal
| pregnancy_AU = B1
| pregnancy_US = C
| legal_status =
| routes_of_administration = Oral
}}
{{CMG}}
__NOTOC__
__NOTOC__


{{Ticlopidine}}


==[[Ticlopidine (patient information)|For patient information, click here]]==
{{CMG}}; {{AE}} {{AZ}}


== Overview ==
'''''For patient information, click <u>[[Ticlopidine (patient information)|here]]'''''</u>.
'''Ticlopidine''' (trade name '''Ticlid''') is an [[antiplatelet drug]] in the thienopyridine family.  Like [[clopidogrel]], it is an [[adenosine diphosphate]] (ADP) receptor inhibitor.  It is used in patients in whom [[aspirin]] is not tolerated, or in whom dual antiplatelet therapy is desirable.  Because it has been reported to increase the risk of [[thrombotic thrombocytopenic purpura]] (TTP) and [[neutropenia]], its use has largely been supplanted by the newer drug, [[clopidogrel]], which is felt to have a much lower hematologic risk. The usual dose is 250mg twice daily by the oral route.
{{SB}} Ticlopidine<sup>®</sup>


== Action ==
==Overview==
* Inihibits [[platelet]] aggregation by altering the function of platelet membranes.
* Prolongs bleeding time.
* Decreased incidence of [[stroke]] in high-risk patients.


== Contraindications ==
==Category==
* [[Hypersensitivity]]
* Bleeding disorders
* Active bleeding
* Severe [[liver disease]]


== Precautions ==
==FDA Package Insert==
* Risk of bleeding ([[Physical trauma|trauma]], surgery, history of [[peptic ulcer disease]])
* [[Renal]] or [[hepatic]] impairment
* [[Geriatric]] patients (increased sensitivity)
* [[Pregnancy]], [[lactation]], or children under 18


{{Antithrombotics}}
'''| [[Ticlopidine indications and usage|Indications and Usage]]'''
'''| [[Ticlopidine dosage and administration|Dosage and Administration]]'''
'''| [[Ticlopidine dosage forms and strengths|Dosage Forms and Strengths]]'''
'''| [[Ticlopidine contraindications|Contraindications]]'''
'''| [[Ticlopidine warnings|Warnings and Precautions]]'''
'''| [[Ticlopidine adverse reactions|Adverse Reactions]]'''
'''| [[Ticlopidine drug interactions|Drug Interactions]]'''
'''| [[Ticlopidine use in specific populations|Use in Specific Populations]]'''
'''| [[Ticlopidine overdosage|Overdosage]]'''
'''| [[Ticlopidine description|Description]]'''
'''| [[Ticlopidine clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Ticlopidine nonclinical toxicology|Nonclinical Toxicology]]'''
'''| [[Ticlopidine clinical studies|Clinical Studies]]'''
'''| [[Ticlopidine how supplied storage and handling|How Supplied/Storage and Handling]]'''
'''| [[Ticlopidine patient counseling information|Patient Counseling Information]]'''
'''| [[Ticlopidine labels and packages|Labels and Packages]]'''


[[Category:ADP receptor inhibitors]]
==Mechanism of Action==
[[Category:Thiophenes]]
[[Category:Drugs]]


==References==


[[de:Ticlopidin]]
{{Reflist|2}}
[[it:Ticlopidina]]
[[pt:Ticlopidina]]
[[zh:噻氯匹定]]


 
[[Category:Drugs]]
 
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}

Revision as of 00:32, 6 February 2014


Ticlopidine
Ticlopidine® FDA Package Insert
Indications and Usage
Dosage and Administration
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Overdosage
Description
Clinical Pharmacology
Nonclinical Toxicology
Clinical Studies
How Supplied/Storage and Handling
Patient Counseling Information
Labels and Packages
Clinical Trials on Ticlopidine
ClinicalTrials.gov

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Zaghw, M.D. [2]

For patient information, click here. Synonyms / Brand Names: Ticlopidine®

Overview

Category

FDA Package Insert

| Indications and Usage | Dosage and Administration | Dosage Forms and Strengths | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Use in Specific Populations | Overdosage | Description | Clinical Pharmacology | Nonclinical Toxicology | Clinical Studies | How Supplied/Storage and Handling | Patient Counseling Information | Labels and Packages

Mechanism of Action

References

Retrieved from "https://www.wikidoc.org/index.php?title=Ticlopidine&oldid=939005"