Glafenine: Difference between revisions

Glafenine
	Error creating thumbnail: File missing
Clinical data
ATC code	N02BG03 (WHO) ;
Identifiers
	IUPAC name 2,3-Dihydroxypropyl 2-[(7-chloro-4-quinolinyl)amino]benzoate;
CAS Number	3820-67-5;
PubChem CID	3474;
ChemSpider	3355;
ChEBI	CHEBI:31653 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C19H17ClN2O4
Molar mass	372.802 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC(O)CO)c1ccccc1Nc2c3ccc(Cl)cc3ncc2;
	InChI InChI=1S/C19H17ClN2O4/c20-12-5-6-14-17(7-8-21-18(14)9-12)22-16-4-2-1-3-15(16)19(25)26-11-13(24)10-23/h1-9,13,23-24H,10-11H2,(H,21,22); Key:GWOFUCIGLDBNKM-UHFFFAOYSA-N;

VisualWikitext

Revision as of 19:35, 4 February 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

For patient information about Glafenine, click here

Synonyms / Brand Names:

Overview

Glafenine is a non-steroidal anti-inflammatory drug (NSAID). Use of glafenine is limited due to the risk of anaphylaxis and acute renal failure.^[1]^[2]

FDA Package Insert

Mechanism of Action

References

↑ "Withdrawal of glafenine". The Lancet. 339 (8789): 357. 1992. doi:10.1016/0140-6736(92)91670-4.
↑ Kleinknecht, D; Landais, P; Goldfarb, B (1986). "Analgesic and non-steroidal anti-inflammatory drug-associated acute renal failure: A prospective collaborative study". Clinical nephrology. 25 (6): 275–81. PMID 2873910.

[1] "Withdrawal of glafenine". The Lancet. 339 (8789): 357. 1992. doi:10.1016/0140-6736(92)91670-4.

[2] Kleinknecht, D; Landais, P; Goldfarb, B (1986). "Analgesic and non-steroidal anti-inflammatory drug-associated acute renal failure: A prospective collaborative study". Clinical nephrology. 25 (6): 275–81. PMID 2873910.

[1]

[2]

@@ Line 1: / Line 1: @@
+{{Drugbox
+| drug_name         = Glafenine
+| IUPAC_name        = 2,3-Dihydroxypropyl 2-[(7-chloro-4-quinolinyl)amino]benzoate
+| image             = Glafenine.svg
+| width             = 180
+| caption           =
+<!-- Clinical data -->
+| tradename         =
+| Drugs.com         =
+| MedlinePlus       =
+| pregnancy_AU      = <!-- A / B1 / B2 / B3 / C / D / X -->
+| pregnancy_US      = <!-- A / B            / C / D / X -->
+| pregnancy_category=
+| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
+| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
+| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM -->
+| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
+| legal_status      =
+| routes_of_administration =
+<!-- Pharmacokinetic data -->
+| bioavailability   =
+| protein_bound     =
+| metabolism        =
+| elimination_half-life =
+| excretion         =
+<!-- Identifiers -->
+| CAS_number        = 3820-67-5
+| ATCvet            =
+| ATC_prefix        = N02
+| ATC_suffix        = BG03
+| PubChem           = 3474
+| ChEBI_Ref = {{ebicite|correct|EBI}}
+| ChEBI = 31653
+| DrugBank          =
+| ChemSpiderID      = 3355
+<!-- Chemical data -->
+| C=19 | H=17 | Cl=1 | N=2 | O=4
+| molecular_weight  = 372.802 g/mol
+| smiles            = O=C(OCC(O)CO)c1ccccc1Nc2c3ccc(Cl)cc3ncc2
+| InChI             = 1/C19H17ClN2O4/c20-12-5-6-14-17(7-8-21-18(14)9-12)22-16-4-2-1-3-15(16)19(25)26-11-13(24)10-23/h1-9,13,23-24H,10-11H2,(H,21,22)
+| InChIKey          = GWOFUCIGLDBNKM-UHFFFAOYAI
+| StdInChI          = 1S/C19H17ClN2O4/c20-12-5-6-14-17(7-8-21-18(14)9-12)22-16-4-2-1-3-15(16)19(25)26-11-13(24)10-23/h1-9,13,23-24H,10-11H2,(H,21,22)
+| StdInChIKey       = GWOFUCIGLDBNKM-UHFFFAOYSA-N
+}}
 __NOTOC__
 {{CMG}}; {{AE}}
@@ Line 7: / Line 55: @@
 ==Overview==
+'''Glafenine''' is a [[non-steroidal anti-inflammatory drug]] (NSAID).  Use of glafenine is limited due to the risk of [[anaphylaxis]] and [[acute renal failure]].<ref>{{Cite journal | doi = 10.1016/0140-6736(92)91670-4 | title = Withdrawal of glafenine | year = 1992 | journal = The Lancet | volume = 339 | issue = 8789 | pages = 357}}</ref><ref>{{Cite journal | pmid = 2873910 | year = 1986 | last1 = Kleinknecht | first1 = D | last2 = Landais | first2 = P | last3 = Goldfarb | first3 = B | title = Analgesic and non-steroidal anti-inflammatory drug-associated acute renal failure: A prospective collaborative study | volume = 25 | issue = 6 | pages = 275–81 | journal = Clinical nephrology}}</ref>
 ==Category==

Clinical data
Error creating thumbnail: File missing
ATC code	N02BG03 (WHO)
Identifiers
IUPAC name 2,3-Dihydroxypropyl 2-[(7-chloro-4-quinolinyl)amino]benzoate
CAS Number	3820-67-5
PubChem CID	3474
ChemSpider	3355
ChEBI	CHEBI:31653^Y
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₁₉H₁₇ClN₂O₄
Molar mass	372.802 g/mol
3D model (JSmol)	Interactive image
SMILES O=C(OCC(O)CO)c1ccccc1Nc2c3ccc(Cl)cc3ncc2
InChI InChI=1S/C19H17ClN2O4/c20-12-5-6-14-17(7-8-21-18(14)9-12)22-16-4-2-1-3-15(16)19(25)26-11-13(24)10-23/h1-9,13,23-24H,10-11H2,(H,21,22) Key:GWOFUCIGLDBNKM-UHFFFAOYSA-N