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Interim clinical, laboratory and epidemiologic criteria for case classification — U.S. Monkeypox Response, May 2022
{| class="wikitable"
|Clinical and laboratory classification
|Criteria
|-
|Suspected
|New characteristic rash* OR
|-
|
|Meets one of the epidemiologic criteria and has high clinical suspicion† for monkeypox
|-
|Probable
|No suspicion of other recent orthopoxvirus exposure (e.g., Vaccinia virus in ACAM2000 vaccination) AND demonstration of the presence of
|-
|
|•     Orthopoxvirus DNA by polymerase chain reaction testing of a clinical specimen OR
|-
|
|•     Orthopoxvirus using immunohistochemical or electron microscopy testing methods
start highlight
OR
end highlight
|-
|
|start highlight
•     Detectable levels of antiorthopoxvirus IgM antibody during the period of 4–56 days after rash onset
end highlight
|-
|Confirmed
|Demonstration of the presence of Monkeypox virus DNA by polymerase chain reaction testing or next-generation sequencing of a clinical specimen OR
|-
|
|Isolation of Monkeypox virus in culture from a clinical specimen
|-
|Epidemiologic classification
|
|}
__NOTOC__
__NOTOC__
{{Monkeypox}}
{{Monkeypox}}

Revision as of 20:26, 14 June 2022

Interim clinical, laboratory and epidemiologic criteria for case classification — U.S. Monkeypox Response, May 2022

Clinical and laboratory classification Criteria
Suspected New characteristic rash* OR
Meets one of the epidemiologic criteria and has high clinical suspicion† for monkeypox
Probable No suspicion of other recent orthopoxvirus exposure (e.g., Vaccinia virus in ACAM2000 vaccination) AND demonstration of the presence of
•     Orthopoxvirus DNA by polymerase chain reaction testing of a clinical specimen OR
•     Orthopoxvirus using immunohistochemical or electron microscopy testing methods

start highlight

OR

end highlight

start highlight

•     Detectable levels of antiorthopoxvirus IgM antibody during the period of 4–56 days after rash onset

end highlight

Confirmed Demonstration of the presence of Monkeypox virus DNA by polymerase chain reaction testing or next-generation sequencing of a clinical specimen OR
Isolation of Monkeypox virus in culture from a clinical specimen
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