Lactic acidosis differential diagnosis: Difference between revisions

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==Overview==
Lactic acidosis must be differentiated from other diseases that cause elevated lactate Any shock state or dysfunction of the metabolic pathway responsible for lactate clearance or production can underlie lactic acidosis. A few are:


== Overview ==
*Inborn errors of metabolism
There are certain conditions to be kept in mind for a diagnosis of lactic acidosis:
*Cardiogenic shock
*Cardiogenic pulmonary edema


* Inborn errors of metabolism
==Differentiating Lactic acidosis from other Diseases==
* Cardiogenic shock
* Cardiogenic pulmonary edema
 
== Differentiating Lactic acidosis from other Diseases ==
Lactic acidosis should be differentiated from:
Lactic acidosis should be differentiated from:


*Any shock state
*Any shock state
*SIRS; lactate may be 2-5 mEq/L
*[[Systemic inflammatory response syndrome|SIRS]]; lactate may be 2-5 mEq/L
*Thiamine deficiency
*[[Beriberi|Thiamine deficiency]]
*Seizures
*D-lactic acidosis
*[[Seizure|Seizures]]
*Infarcted colon
*Infarcted colon
*Hepatic failure
*[[Hepatic failure]]
*Malignancy
*Malignancy
*Heavy exercise
*Heavy exercise
*Albuterol and other beta agonists
*Albuterol and other beta agonists
*Toxicologic Causes:
*Toxicologic Causes:
**Cyanide
**[[Cyanide poisoning|Cyanide]]
**Carbon Monoxide
**[[Carbon monoxide|Carbon Monoxide]]
**Metformin use in diabetics
**Metformin use in diabetics
**Didanosine
**Didanosine
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**Linezolid
**Linezolid
**Strychnine
**Strychnine
**Rotenone (Fish Poison
**[[Rotenone]] (Fish Poison)
**Phospine (rodenticide)
**Phospine (rodenticide)
**INH (if patient seizes)
**INH (if patient seizes)
**Valproate
**Valproate
**Hydrogen Sulfide
**Hydrogen Sulfide
**Nitroprusside (cyanide)
**[[Nitroprusside adverse reactions|Nitroprusside]] (cyanide)
**Ricin & Castor Beans
**Ricin & Castor Beans
**Propofol
**Propofol

Revision as of 11:45, 19 November 2021


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: '''Synonyms and keywords:

Overview

Lactic acidosis must be differentiated from other diseases that cause elevated lactate Any shock state or dysfunction of the metabolic pathway responsible for lactate clearance or production can underlie lactic acidosis. A few are:

  • Inborn errors of metabolism
  • Cardiogenic shock
  • Cardiogenic pulmonary edema

Differentiating Lactic acidosis from other Diseases

Lactic acidosis should be differentiated from:

  • Any shock state
  • SIRS; lactate may be 2-5 mEq/L
  • Thiamine deficiency
  • D-lactic acidosis
  • Seizures
  • Infarcted colon
  • Hepatic failure
  • Malignancy
  • Heavy exercise
  • Albuterol and other beta agonists
  • Toxicologic Causes:
    • Cyanide
    • Carbon Monoxide
    • Metformin use in diabetics
    • Didanosine
    • Stavudine
    • Zidovudine
    • Linezolid
    • Strychnine
    • Rotenone (Fish Poison)
    • Phospine (rodenticide)
    • INH (if patient seizes)
    • Valproate
    • Hydrogen Sulfide
    • Nitroprusside (cyanide)
    • Ricin & Castor Beans
    • Propofol
    • Sympathomimetics (cocaine, methamphetamine)

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