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| {| class="wikitable sortable"
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| ! Drug Class
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| ! Drug
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| ! Initial daily dose, target dose (mg)
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| ! Preferred use
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| ! Preferably combined with
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| |-
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| | rowspan="4" | [[Thiazide diuretics]] || [[Chlorthalidone]] || 12.5, 12.5-25|| rowspan="4" | [[Heart failure]], [[systolic hypertension|isolated systolic hypertension]], black population|| rowspan="4" | [[ACE inhibitors]], [[ARBs]], [[calcium channel blockers]]
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| |-
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| |[[Hydrochlorothiazide]] || 12.5-25, 25-100
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| |-
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| |[[Bendroflumethiazide]] || 5, 10
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| |-
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| |[[Indapamide]] || 1.25, 1.25-2.5
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| |-
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| | rowspan="3" | [[ACE inhibitors]] || [[Enalapril]] || 5, 20|| rowspan="3" | [[Left ventricular hypertrophy]], [[atherosclerosis]], [[renal insufficiency]], previous [[myocardial infarction]], [[heart failure]], [[atrial fibrillation]] (prevention), [[peripheral artery disease]], [[metabolic syndrome]], [[diabetes mellitus]]|| rowspan="3" | [[Calcium channel blockers]], [[thiazide diuretics]]
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| |-
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| |[[Lisinopril]] || 10, 40
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| |-
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| |[[Captopril]] || 50, 150-200
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| |-
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| | rowspan="5" | [[ARBs]] || [[Candesartan]] || 4, 12-32|| rowspan="5" | [[Left ventricular hypertrophy]], [[renal insufficiency]], previous [[myocardial infarction]], [[heart failure]], [[atrial fibrillation]] (prevention), [[metabolic syndrome]], [[diabetes mellitus]]|| rowspan="5" | [[Calcium channel blockers]], [[thiazide diuretics]]
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| |-
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| |[[Losartan]] || 50, 100
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| |-
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| |[[Valsartan]] || 40-80, 160-320
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| |-
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| |[[Eprosartan]] || 400, 600-800
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| |-
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| |[[Irbesartan]] || 75, 300
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| |-
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| | rowspan="2" | [[Beta blockers]] || [[Atenolol]] || 25-50, 100|| rowspan="2" | Previous [[myocardial infarction]], [[atrial fibrillation]] (prevention and ventricular rate control), [[heart failure]], [[Chronic stable angina|angina pectoris]], [[aortic aneurysm]], [[pregnancy]]|| rowspan="2" | [[Thiazide diuretics]] (with limitations)<br>'''Only [[Calcium channel blocker#Dihydropyridine|dihydropyridine calcium channel blockers]] should be combined with [[beta blockers]]'''
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| |-
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| |[[Metoprolol succinate]] || 50, 100-200
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| |-
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| | rowspan="3" | [[Calcium channel blockers]]|| [[Amlodipine]] || 2.5, 10|| rowspan="3" | [[Left ventricular hypertrophy]], [[pregnancy]] ([[nifedipine]]), previous [[myocardial infarction]], [[atrial fibrillation]] ([[verapamil]], [[diltiazem]]), [[metabolic syndrome]], [[peripheral artery disease]], [[atherosclerosis]], [[Chronic stable angina|angina pectoris]], [[systolic hypertension|isolated systolic hypertension]], black population|| rowspan="3" | [[ACE inhibitors]], [[ARBs]], [[thiazide diuretics]]
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| |-
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| |[[Diltiazem extended release]] || 120-180, 360
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| |-
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| |[[Nitrendipine]] || 10, 20
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| |-
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| |}
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