Sandbox:Roukoz

Diseases	Clinical manifestations						Para-clinical findings				Additional findings
	Symptoms			Physical examination
							Lab Findings			Histopathology
	Symptom 1	Symptom 2	Symptom 3	Physical exam 1	Physical exam 2	Physical exam 3	Presentation	Areas affected	Unique features
Cutaneous squamous cell carcinoma	Pain	Erythema		Indurated	Hyperkeratotic	Increased size	papules, plaques, or nodules, and smooth, hyperkeratotic, or ulcerative lesions	any cutaneous surface, including the head, neck, trunk, extremities, oral mucosa, periungual skin, and anogenital areas	In fair-skinned individuals, SCCs most commonly arise in sites frequently exposed to the sun		60 percent of squamous cell carcinomas occur at the site of a previous actinic keratosis
Merkel cell carcinoma				Starts on areas of skin exposed to the sun	Single pink, red, or purple shiny bump	Painless					Blue-red, dome-shaped nodule
Nodular malignant melanoma				Lump that has been rapidly growing over the past weeks						Cells proliferate downwards through the skin (vertical growth)	Two-thirds arise in normal skin, the rest in existing moles Genetic component in some cases with a positive family history
Amelanotic melanoma				Color usually pink, purple or normal skin color	Usually have an asymmetrical shape with an irregular border	Red, nonspecific lesion with slightly elevated borders					Do not make melanin, so lesions are not pigmented
Basal cell carcinoma				Coarse scale lesion
Superficial basal cell carcinoma				Scaly patch	Erythematous lesion					large, hyperchromatic, oval nuclei and little cytoplasm well differentiated and cells appear histologically similar to basal cells of the epidermis
Nodular basal cell carcinoma				Pearly papule with telangiectasias
Cutaneous metastases of internal malignancy				Other sites lungs, liver, brain, skin, or bone.							The most frequent site of metastasis for cutaneous SCC is the regional lymph nodes;
Benign Skin Lesions
Sebaceous cell carcinoma				Yellow-nodule							Suspected due to evidence of eyelash loss
Rhabdomyosarcoma	Bulging of the eye or a swollen eyelid										Develops in skeletal muscles usually
Actinic keratoses	Pain			Hyperkeratosis	Erythema	less pigmentation, and tend to be somewhat smaller in size.
Prurigo nodules	Hard lesion	Itchy lumps
Paget disease				Eczema-like rash of the skin	Around the genital regions of males and females.					Similar to mammary paget disease	chronic
Inflamed seborrheic keratosis				Waxy, "stuck on," often hyperkeratotic appearance
Viral warts				Verrucous lesion							Caused by HPV
Pyogenic granuloma				Rapidly growing	Red, dome-shaped	Friable papule with a collarette of scale
Bowenoid papulosis				multiple, red- to brown-colored, small papules that							primarily arise on genitals induced by human papillomavirus (HPV) infection
Nummular eczema	Itchy lesions			Coin shaped spots							Chronic condition
Psoriasis	Flaking, inflammation			Thick, white, silvery, or red patches of skin							Chronic condition
Pyoderma gangrenosum				Purulent ulcer	Ragged and violaceous border
Venous stasis ulcers
Traumatic ulcers
Bowen Disease				Red scaly patch							Very early form of skin cancer that is very treatable referred to as squamous cell carcinoma insitu
Sebaceous Hyperplasia				Lesions can be single or multiple lesions	Yellowish, soft, small papules on the face	Usually on the nose, cheeks, and forehead
Allergic Contact Dermatitis	Itchy rash			Red rash							Not contagious
Atopic Dermatitis	Itchy rash	Fever		Red rash							Chronic and sometimes accompanied by asthma
Atypical Fibroxanthoma				Erythematous, dome-shaped papule
Nevus
Chemical Burns
Limbal Dermoid										Contains choristomatous tissue	Benign congenital tumor
Benign hereditary intraepithelial dyskeratosis											Rare autosomal-dominant disorder of the conjunctiva and oral mucosa
primary acquired melanosis
Fibrous xanthoma										Containing fibromatous elements	Arises due to disturbed systemic lipid metabolism
Inflamed seborrheic keratosis				Inflamed and hyperpigmented		On dermatoscopic evaluation, presence of horned cysts and hairpin-shaped blood vessels
Juvenile xanthogranuloma				Reddened, yellowish-tan color of lesions	Slightly raised bumps						Typically
Cutaneous fungal infections
Desmoplastic trichoepithelioma
Adnexal carcinoma											Very rare
Keratoacanthoma
Darier disease											Keratosis follicularis
Cutaneous T-cell lymphoma											Mycosis fungoides
Marjolin's ulcer				Lesions in sites of chronic wounds and scars	Excessive granulation tissue,	Rolled or everted wound margins	Bleeding on touch				rare type of SCC Very slow malignant transformation
Epithelioma cuniculatum							Increased size				Verrucous carcinoma on the plantar foot
Anogenital											also known as giant condyloma acuminatum of Buschke-Loewenstein
Keratoacanthoma				Found on actinically damaged skin	Rapid initial growth	Dome-shaped or crateriform nodules with a central keratotic core	Increased size				keratocytic epithelial tumors