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| align="center" style="background:#F5F5F5;" + |Beta F1+, [[CD2]]-/+, [[CD3]]+, [[CD3]]- ([[CD4]]-positive variant), [[CD4]]+ ([[CD4]]-positive variant), [[CD4]]-, [[CD5]]-, [[CD7]]+/-, [[CD8]]+, [[CD8]]- ([[CD4]]-positive variant), [[Granzyme B|Granzyme B+]], and [[perforin]]+
| align="center" style="background:#F5F5F5;" + |Beta F1+, [[CD2]]-/+, [[CD3]]+, [[CD3]]- ([[CD4]]-positive variant), [[CD4]]+ ([[CD4]]-positive variant), [[CD4]]-, [[CD5]]-, [[CD7]]+/-, [[CD8]]+, [[CD8]]- ([[CD4]]-positive variant), [[Granzyme B|Granzyme B+]], and [[perforin]]+
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:* polymorphous inflammatory infiltrate in the dermis that contains small numbers of frankly atypical [[lymphoid]] cells
:* These cells may line up individually along the epidermal basal layer
:* The presence of spongiosis is highly suggestive of mycosis fungoides
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Revision as of 15:28, 21 January 2019


xray showing femur fracture source:Case courtesy of Dr Andrew Dixon, Radiopaedia.org, rID: 25704


X-ray showing Humerus Fracture source:Case courtesy of Dr Benoudina Samir, Radiopaedia.org, rID: 22063


X-Ray showing Tibial Fracture source:Case courtesy of MD PhD gasssss, Radiopaedia.org, rID: 13768


==References==

Differentiating NHL

Category Disease Etiology Constitutional symptoms Rash Abdominal pain Diarrhea Mass Other WBC Hb Plt Immunochemistry Histopathology Gold standard Associated findings
T cell lymphoma Precursor T-cell lymphoblastic leukemia/lymphoma
  • Precursor T-cell Lymphomas
T-cell granular lymphocytic
T-cell prolymphocytic leukemia
Adult T cell leukemia/lymphoma[1][2][3]
  • Mature T-cell Lymphoma
  • Human T-lymphotrophic virus 1 infection
  • Hepatospleanomagaly
  • Hypercalcemia
  • Skin lesions
  • Lytic bone lesions
  • Elevated LDH
  • T-cell deficiency leading immunodeficiency causing opportunistic infection
+
  • Anemia
  • Thrombocytopenia
  • Elevated lymphocyte count
  • Adult T-cell leukemia cells are typically CD2, CD4, CD5, and CD8 positive
  • Charecterstic leukemia cells with sharp nuclear indentations and a prominent nucleoli
  • "Cloverleaf" or "flower" cells
Hypercalcemia
Anaplastic large cell lymphoma[4][5][6][7]
  • Mature T-cell Lymphoma
+ +
  • Strongly immunoreactive for CD30, Anaplastic lymphoma kinase (ALK), EMA, and vimentin
  • Nucleoli tend to be more prominent
  • The cytoplasm may be either basophilic or eosinophilic and the cell might have many nuclei with dispersed or clumped chromatin
Cutaneous T-cell lymphoma Mycosis fungoides / Sézary syndrome
  • Cutaneous manifestations
Beta F1+, CD2-/+, CD3+, CD3- (CD4-positive variant), CD4+ (CD4-positive variant), CD4-, CD5-, CD7+/-, CD8+, CD8- (CD4-positive variant), Granzyme B+, and perforin+
  • polymorphous inflammatory infiltrate in the dermis that contains small numbers of frankly atypical lymphoid cells
  • These cells may line up individually along the epidermal basal layer
  • The presence of spongiosis is highly suggestive of mycosis fungoides
Peripheral T-cell lymphoma Subcutaneous panniculitis-like T-cell lymphoma
  • Mature T-cell Lymphoma
Hepatosplenic T-cell lymphoma
  • Mature T-cell Lymphoma
Enteropathy-type intestinal T-cell lymphoma
  • Mature T-cell Lymphoma
Extranodal T-cell lymphoma, nasal type
  • Mature T-cell Lymphoma
Angioimmunoblastic T-cell lymphoma
  • Mature T-cell Lymphoma
Peripheral T-cell lymphoma, unspecified
  • Mature T-cell Lymphoma
  1. Matutes E (2007). "Adult T-cell leukaemia/lymphoma". J. Clin. Pathol. 60 (12): 1373–7. doi:10.1136/jcp.2007.052456. PMC 2095573. PMID 18042693.
  2. Matutes E (2007) Adult T-cell leukaemia/lymphoma. J Clin Pathol 60 (12):1373-7. DOI:10.1136/jcp.2007.052456 PMID: 18042693
  3. Shimoyama M (1991). "Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87)". Br J Haematol. 79 (3): 428–37. PMID 1751370.
  4. Al-Ahmad, Selma; Maertens, Vincent; Libeer, Christophe; Schelfhout, Vera; Vanhoenacker, Filip; Boeckx, Nancy; Vandevenne, Marleen (2017). "The masquerading presentation of a systemic anaplastic large cell lymphoma, ALK positive: a case report and review of the literature". Acta Clinica Belgica. 72 (6): 454–460. doi:10.1080/17843286.2017.1312057. ISSN 1784-3286.
  5. Yu L, Yan LL, Yang SJ (2014). "Sarcomatoid variant of ALK- anaplastic large cell lymphoma involving multiple lymph nodes and both lungs with production of proinflammatory cytokines: report of a case and review of literature". Int J Clin Exp Pathol. 7 (8): 4806–16. PMC 4152041. PMID 25197351.
  6. de Campos FPF, Zerbini MCN, Felipe-Silva A, Simões AB, Lovisolo SM, da Fonseca LG; et al. (2014). "Unusual clinical presentation of anaplastic large cell lymphoma". Autops Case Rep. 4 (1): 21–27. doi:10.4322/acr.2014.004. PMC 5470561. PMID 28652989.
  7. Watanabe M, Ogawa Y, Itoh K; et al. (January 2008). "Hypomethylation of CD30 CpG islands with aberrant JunB expression drives CD30 induction in Hodgkin lymphoma and anaplastic large cell lymphoma". Lab. Invest. 88 (1): 48–57. doi:10.1038/labinvest.3700696. PMID 17965727.

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