Merkel cell cancer laboratory tests: Difference between revisions
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==Overview== | ==Overview== | ||
Laboratory findings consistent with the diagnosis of [[merkel cell cancer]] include [[immunohistochemistry]], [[Cytogenetics|cytogenetic]] and [[molecular]] analysis, and [abnormal test 3]. . | |||
==Laboratory findings== | ==Laboratory findings== | ||
Laboratory findings consistent with the diagnosis of merkel cell cancer include: | Laboratory findings consistent with the diagnosis of [[merkel cell cancer]] include: | ||
'''Immunohistochemistry''' | '''Immunohistochemistry''' | ||
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** Epithelial membrane [[antigen]], and | ** Epithelial membrane [[antigen]], and | ||
** Ber-EP4 | ** Ber-EP4 | ||
* [[Merkel cell carcinoma]] may also shows positive for [[neuroendocrine]] markers such as: | |||
** [[Chromogranin]] | |||
** [[Synaptophysin]] | |||
** [[Calcitonin]] and | |||
** [[Vasoactive intestinal peptide]] | |||
'''Cytogenetic and molecular analysis''' | '''Cytogenetic and molecular analysis''' | ||
Revision as of 00:34, 19 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Overview
Laboratory findings consistent with the diagnosis of merkel cell cancer include immunohistochemistry, cytogenetic and molecular analysis, and [abnormal test 3]. .
Laboratory findings
Laboratory findings consistent with the diagnosis of merkel cell cancer include:
Immunohistochemistry
- Epithelial markers play an important role in the diagnosis of merkel cell cancer which include:[1]
- Cytokeratin AE1/AE3
- CAM 5.2
- Pan-cytokeratin
- Epithelial membrane antigen, and
- Ber-EP4
- Merkel cell carcinoma may also shows positive for neuroendocrine markers such as:
Cytogenetic and molecular analysis
References
- ↑ Weinbreck N, Marie B, Bressenot A, Montagne K, Joud A, Baumann C, Klein O, Vignaud JM (July 2008). "Immunohistochemical markers to distinguish between hemangioblastoma and metastatic clear-cell renal cell carcinoma in the brain: utility of aquaporin1 combined with cytokeratin AE1/AE3 immunostaining". Am. J. Surg. Pathol. 32 (7): 1051–9. doi:10.1097/PAS.0b013e3181609d7d. PMID 18496143.