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{{Underlinked|date=April 2014}}
{{Infobox gene}}
{{Infobox gene}}
'''STEAP family member 4''' is a [[protein]] that in humans is encoded by the STEAP4 [[gene]].<ref name="entrez">{{cite web
| title = Entrez Gene: STEAP family member 4 | url = https://www.ncbi.nlm.nih.gov/gene/79689 }}</ref>


'''STEAP family member 4''' is a [[protein]] that in humans is encoded by the STEAP4 [[gene]].
== Function ==
<ref name="entrez">
{{cite web
| title = Entrez Gene: STEAP family member 4
| url = https://www.ncbi.nlm.nih.gov/gene/79689
| accessdate = 2014-01-12 <!-- T22:31:08.793228-08:00 -->
}}</ref>


==Function==
The protein encoded by this gene belongs to the STEAP (six [[Transmembrane protein|transmembrane]] epithelial antigen of prostate) family, and resides in the [[golgi apparatus]]. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene may be involved in adipocyte development and [[metabolism]], and may contribute to the normal biology of the prostate cell, as well as prostate [[cancer]] progression. Alternatively spliced transcript variants encoding different [[Protein isoform|isoforms]] have been found for this gene
 
The protein encoded by this gene belongs to the STEAP (six [[Transmembrane protein|transmembrane]] epithelial antigen of prostate) family, and resides in the [[golgi apparatus]]. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and [[metabolism]], and may contribute to the normal biology of the prostate cell, as well as prostate [[cancer]] progression. Alternatively spliced transcript variants encoding different [[Protein isoform|isoforms]] have been found for this gene. [provided by RefSeq, Apr 2011].


== References ==
== References ==
{{reflist}}
{{reflist}}


== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
*{{Cite journal  
* {{cite journal | vauthors = Zhang CM, Chi X, Wang B, Zhang M, Ni YH, Chen RH, Li XN, Guo XR | title = Downregulation of STEAP4, a highly-expressed TNF-alpha-inducible gene in adipose tissue, is associated with obesity in humans | journal = Acta Pharmacologica Sinica | volume = 29 | issue = 5 | pages = 587–92 | date = May 2008 | pmid = 18430367 | pmc = | doi = 10.1111/j.1745-7254.2008.00793.x }}
| last1 = Zhang | first1 = C. M.
* {{cite journal | vauthors = Bi YW, Wang CM, Yan ZT, Li NF, Guo YY, Wang HM, Yao XG, Liang DP | title = [Negative association of STAMP2 gene polymorphisms with essential hypertension in Xinjiang Uygur population] | journal = Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics | volume = 28 | issue = 1 | pages = 64–8 | date = February 2011 | pmid = 21287513 | pmc =  | doi = 10.3760/cma.j.issn.1003-9406.2011.01.015 }}
| last2 = Chi | first2 = X.
* {{cite journal | vauthors = Kralisch S, Sommer G, Weise S, Lipfert J, Lossner U, Kamprad M, Schröck K, Bluher M, Stumvoll M, Fasshauer M | title = Interleukin-1beta is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro | journal = FEBS Letters | volume = 583 | issue = 7 | pages = 1196–200 | date = April 2009 | pmid = 19289123 | pmc = | doi = 10.1016/j.febslet.2009.03.015 }}
| last3 = Wang | first3 = B.
* {{cite journal | vauthors = Guo YY, Li NF, Wang CM, Yan ZT, Zhang JH, Wang HM, Zhou L, Luo WL | title = [Genetic variation and association of STEAP4 gene with metabolic syndrome in Chinese Uygur patients] | journal = Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics | volume = 28 | issue = 1 | pages = 78–82 | date = February 2011 | pmid = 21287516 | pmc =  | doi = 10.3760/cma.j.issn.1003-9406.2011.01.018 }}
| last4 = Zhang | first4 = M.
* {{cite journal | vauthors = Nanfang L, Yanying G, Hongmei W, Zhitao Y, Juhong Z, Ling Z, Wenli L | title = Variations of six transmembrane epithelial antigen of prostate 4 (STEAP4) gene are associated with metabolic syndrome in a female Uygur general population | journal = Archives of Medical Research | volume = 41 | issue = 6 | pages = 449–56 | date = August 2010 | pmid = 21044749 | pmc = | doi = 10.1016/j.arcmed.2010.08.006 }}
| last5 = Ni | first5 = Y. H.
* {{cite journal | vauthors = Tanaka Y, Matsumoto I, Iwanami K, Inoue A, Minami R, Umeda N, Kanamori A, Ochiai N, Miyazawa K, Sugihara M, Hayashi T, Goto D, Ito S, Sumida T | title = Six-transmembrane epithelial antigen of prostate4 (STEAP4) is a tumor necrosis factor alpha-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis | journal = Modern Rheumatology | volume = 22 | issue = 1 | pages = 128–36 | date = February 2012 | pmid = 21633911 | pmc = | doi = 10.1007/s10165-011-0475-y }}
| last6 = Chen | first6 = R. H.
* {{cite journal | vauthors = Guo YY, Li NF, Zhou L, Yao XG, Wang HM, Zhang JH, Luo WL | title = A common variation within the STEAP4 gene exons is associated with obesity in Uygur general population | journal = Chinese Medical Journal | volume = 124 | issue = 14 | pages = 2096–100 | date = July 2011 | pmid = 21933608 }}
| last7 = Li | first7 = X. N.
* {{cite journal | vauthors = Wangensteen T, Akselsen H, Holmen J, Undlien D, Retterstøl L | title = A common haplotype in NAPEPLD is associated with severe obesity in a Norwegian population-based cohort (the HUNT study) | journal = Obesity | volume = 19 | issue = 3 | pages = 612–7 | date = March 2011 | pmid = 20885390 | pmc = | doi = 10.1038/oby.2010.219 }}
| last8 = Guo | first8 = X. R.
* {{cite journal | vauthors = Korkmaz CG, Korkmaz KS, Kurys P, Elbi C, Wang L, Klokk TI, Hammarstrom C, Troen G, Svindland A, Hager GL, Saatcioglu F | title = Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer | journal = Oncogene | volume = 24 | issue = 31 | pages = 4934–45 | date = July 2005 | pmid = 15897894 | pmc = | doi = 10.1038/sj.onc.1208677 }}
| doi = 10.1111/j.1745-7254.2008.00793.x
| title = Downregulation of STEAP4, a highly-expressed TNF-α-inducible gene in adipose tissue, is associated with obesity in humans  
| journal = Acta Pharmacologica Sinica  
| volume = 29  
| issue = 5  
| pages = 587–592
| year = 2008  
| pmid = 18430367  
| pmc =  
}}
*{{Cite journal  
| last1 = Bi | first1 = Y. W.
| last2 = Wang | first2 = C. M.
| last3 = Yan | first3 = Z. T.
| last4 = Li | first4 = N. F.
| last5 = Guo | first5 = Y. Y.
| last6 = Wang | first6 = H. M.
| last7 = Yao | first7 = X. G.
| last8 = Liang | first8 = D. P.
| title = Negative association of STAMP2 gene polymorphisms with essential hypertension in Xinjiang Uygur population  
| journal = Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
| volume = 28  
| issue = 1  
| pages = 64–68
| year = 2011  
| doi = 10.3760/cma.j.issn.1003-9406.2011.01.015  
| pmid = 21287513
| pmc =
}}
*{{Cite journal  
| last1 = Kralisch | first1 = S.
| last2 = Sommer | first2 = G.
| last3 = Weise | first3 = S.
| last4 = Lipfert | first4 = J.
| last5 = Lossner | first5 = U.
| last6 = Kamprad | first6 = M.
| last7 = Schröck | first7 = K.
| last8 = Bluher | first8 = M.
| last9 = Stumvoll | first9 = M.
| last10 = Fasshauer | first10 = M.
| doi = 10.1016/j.febslet.2009.03.015
| title = Interleukin-1ß is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro  
| journal = FEBS Letters  
| volume = 583  
| issue = 7  
| pages = 1196–1200
| year = 2009  
| pmid = 19289123  
| pmc =  
}}
*{{Cite journal  
| last1 = Guo | first1 = Y. Y.
| last2 = Li | first2 = N. F.
| last3 = Wang | first3 = C. M.
| last4 = Yan | first4 = Z. T.
| last5 = Zhang | first5 = J. H.
| last6 = Wang | first6 = H. M.
| last7 = Zhou | first7 = L.
| last8 = Luo | first8 = W. L.
| title = Genetic variation and association of STEAP4 gene with metabolic syndrome in Chinese Uygur patients  
| journal = Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
| volume = 28  
| issue = 1  
| pages = 78–82  
| year = 2011  
| doi = 10.3760/cma.j.issn.1003-9406.2011.01.018  
| pmid = 21287516
| pmc =
}}
*{{Cite journal  
| last1 = Nanfang | first1 = L.
| last2 = Yanying | first2 = G.
| last3 = Hongmei | first3 = W.
| last4 = Zhitao | first4 = Y.
| last5 = Juhong | first5 = Z.
| last6 = Ling | first6 = Z.
| last7 = Wenli | first7 = L.
| doi = 10.1016/j.arcmed.2010.08.006
| title = Variations of Six Transmembrane Epithelial Antigen of Prostate 4 (STEAP4) Gene Are Associated with Metabolic Syndrome in a Female Uygur General Population
| journal = Archives of Medical Research  
| volume = 41  
| issue = 6  
| pages = 449–456
| year = 2010  
| pmid = 21044749  
| pmc =  
}}
*{{Cite journal  
| last1 = Tanaka | first1 = Y.
| last2 = Matsumoto | first2 = I.
| last3 = Iwanami | first3 = K.
| last4 = Inoue | first4 = A.
| last5 = Minami | first5 = R.
| last6 = Umeda | first6 = N.
| last7 = Kanamori | first7 = A.
| last8 = Ochiai | first8 = N.
| last9 = Miyazawa | first9 = K.
| last10 = Sugihara | first10 = M.
| last11 = Hayashi | first11 = T.
| last12 = Goto | first12 = D.
| last13 = Ito | first13 = S.
| last14 = Sumida | first14 = T.
| title = Six-transmembrane epithelial antigen of prostate4 (STEAP4) is a tumor necrosis factor alpha-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis  
| doi = 10.1007/s10165-011-0475-y
| journal = Modern Rheumatology  
| volume = 22  
| issue = 1  
| pages = 128–136
| year = 2011
| pmid = 21633911  
| pmc =  
}}
*{{Cite journal  
| last1 = Guo | first1 = Y. Y.
| last2 = Li | first2 = N. F.
| last3 = Zhou | first3 = L.
| last4 = Yao | first4 = X. G.
| last5 = Wang | first5 = H. M.
| last6 = Zhang | first6 = J. H.
| last7 = Luo | first7 = W. L.
| title = A common variation within the STEAP4 gene exons is associated with obesity in Uygur general population  
| journal = Chinese medical journal
| volume = 124  
| issue = 14  
| pages = 2096–2100
| year = 2011  
| pmid = 21933608
}}
*{{Cite journal  
| last1 = Wangensteen | first1 = T.
| last2 = Akselsen | first2 = H.
| last3 = Holmen | first3 = J.
| last4 = Undlien | first4 = D.
| last5 = Retterstøl | first5 = L.
| title = A Common Haplotype in NAPEPLD is Associated with Severe Obesity in a Norwegian Population-Based Cohort (the HUNT Study)  
| doi = 10.1038/oby.2010.219
| journal = Obesity  
| volume = 19  
| issue = 3  
| pages = 612–617
| year = 2010
| pmid = 20885390  
| pmc =  
}}
*{{Cite journal  
| last1 = Korkmaz | first1 = C. G.
| last2 = Korkmaz | first2 = K. S.
| last3 = Kurys | first3 = P.
| last4 = Elbi | first4 = C.
| last5 = Wang | first5 = L.
| last6 = Klokk | first6 = T. I.
| last7 = Hammarstrom | first7 = C.
| last8 = Troen | first8 = G.
| last9 = Svindland | first9 = A.
| last10 = Hager | first10 = G. L.
| last11 = Saatcioglu | first11 = F.
| doi = 10.1038/sj.onc.1208677
| title = Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer  
| journal = Oncogene  
| volume = 24  
| issue = 31  
| pages = 4934–4945
| year = 2005  
| pmid = 15897894  
| pmc =  
}}
 
{{refend}}
{{refend}}


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[[Category:Genes on human chromosome 7]]
[[Category:Genes on human chromosome 7]]


{{gene-7-stub}}
{{gene-7-stub}}

Latest revision as of 02:23, 22 March 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

STEAP family member 4 is a protein that in humans is encoded by the STEAP4 gene.[1]

Function

The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene may be involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene

References

  1. ↑ "Entrez Gene: STEAP family member 4".

Further reading

  • Zhang CM, Chi X, Wang B, Zhang M, Ni YH, Chen RH, Li XN, Guo XR (May 2008). "Downregulation of STEAP4, a highly-expressed TNF-alpha-inducible gene in adipose tissue, is associated with obesity in humans". Acta Pharmacologica Sinica. 29 (5): 587–92. doi:10.1111/j.1745-7254.2008.00793.x. PMID 18430367.
  • Bi YW, Wang CM, Yan ZT, Li NF, Guo YY, Wang HM, Yao XG, Liang DP (February 2011). "[Negative association of STAMP2 gene polymorphisms with essential hypertension in Xinjiang Uygur population]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics. 28 (1): 64–8. doi:10.3760/cma.j.issn.1003-9406.2011.01.015. PMID 21287513.
  • Kralisch S, Sommer G, Weise S, Lipfert J, Lossner U, Kamprad M, Schröck K, Bluher M, Stumvoll M, Fasshauer M (April 2009). "Interleukin-1beta is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro". FEBS Letters. 583 (7): 1196–200. doi:10.1016/j.febslet.2009.03.015. PMID 19289123.
  • Guo YY, Li NF, Wang CM, Yan ZT, Zhang JH, Wang HM, Zhou L, Luo WL (February 2011). "[Genetic variation and association of STEAP4 gene with metabolic syndrome in Chinese Uygur patients]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics. 28 (1): 78–82. doi:10.3760/cma.j.issn.1003-9406.2011.01.018. PMID 21287516.
  • Nanfang L, Yanying G, Hongmei W, Zhitao Y, Juhong Z, Ling Z, Wenli L (August 2010). "Variations of six transmembrane epithelial antigen of prostate 4 (STEAP4) gene are associated with metabolic syndrome in a female Uygur general population". Archives of Medical Research. 41 (6): 449–56. doi:10.1016/j.arcmed.2010.08.006. PMID 21044749.
  • Tanaka Y, Matsumoto I, Iwanami K, Inoue A, Minami R, Umeda N, Kanamori A, Ochiai N, Miyazawa K, Sugihara M, Hayashi T, Goto D, Ito S, Sumida T (February 2012). "Six-transmembrane epithelial antigen of prostate4 (STEAP4) is a tumor necrosis factor alpha-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis". Modern Rheumatology. 22 (1): 128–36. doi:10.1007/s10165-011-0475-y. PMID 21633911.
  • Guo YY, Li NF, Zhou L, Yao XG, Wang HM, Zhang JH, Luo WL (July 2011). "A common variation within the STEAP4 gene exons is associated with obesity in Uygur general population". Chinese Medical Journal. 124 (14): 2096–100. PMID 21933608.
  • Wangensteen T, Akselsen H, Holmen J, Undlien D, Retterstøl L (March 2011). "A common haplotype in NAPEPLD is associated with severe obesity in a Norwegian population-based cohort (the HUNT study)". Obesity. 19 (3): 612–7. doi:10.1038/oby.2010.219. PMID 20885390.
  • Korkmaz CG, Korkmaz KS, Kurys P, Elbi C, Wang L, Klokk TI, Hammarstrom C, Troen G, Svindland A, Hager GL, Saatcioglu F (July 2005). "Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer". Oncogene. 24 (31): 4934–45. doi:10.1038/sj.onc.1208677. PMID 15897894.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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