SEPT5: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Bot: HTTP→HTTPS)
(→‎Interactions: added an author link)
Line 9: Line 9:


SEPT5 has been shown to [[Protein-protein interaction|interact]] with:
SEPT5 has been shown to [[Protein-protein interaction|interact]] with:
* [[Parkin (ligase)|PARK2]],<ref name = pmid14559152>{{cite journal | vauthors = Choi P, Snyder H, Petrucelli L, Theisler C, Chong M, Zhang Y, Lim K, Chung KK, Kehoe K, D'Adamio L, Lee JM, Cochran E, Bowser R, Dawson TM, Wolozin B | author15-link=Benjamin Wolozin | title = SEPT5_v2 is a parkin-binding protein | journal = Brain Research. Molecular Brain Research | volume = 117 | issue = 2 | pages = 179–89 | date = October 2003 | pmid = 14559152 | doi = 10.1016/S0169-328X(03)00318-8 }}</ref><ref name = pmid18845538>{{cite journal | vauthors = Liu M, Aneja R, Sun X, Xie S, Wang H, Wu X, Dong JT, Li M, Joshi HC, Zhou J | title = Parkin regulates Eg5 expression by Hsp70 ubiquitination-dependent inactivation of c-Jun NH2-terminal kinase | journal = The Journal of Biological Chemistry | volume = 283 | issue = 51 | pages = 35783–8 | date = December 2008 | pmid = 18845538 | doi = 10.1074/jbc.M806860200 }}</ref> and
* [[Parkin (ligase)|PARK2]],<ref name = pmid14559152>{{cite journal | vauthors = Choi P, Snyder H, Petrucelli L, Theisler C, Chong M, Zhang Y, Lim K, Chung KK, Kehoe K, D'Adamio L, Lee JM, Cochran E, Bowser R, Dawson TM, Wolozin B | author14-link=Ted M. Dawson | author15-link=Benjamin Wolozin | title = SEPT5_v2 is a parkin-binding protein | journal = Brain Research. Molecular Brain Research | volume = 117 | issue = 2 | pages = 179–89 | date = October 2003 | pmid = 14559152 | doi = 10.1016/S0169-328X(03)00318-8 }}</ref><ref name = pmid18845538>{{cite journal | vauthors = Liu M, Aneja R, Sun X, Xie S, Wang H, Wu X, Dong JT, Li M, Joshi HC, Zhou J | title = Parkin regulates Eg5 expression by Hsp70 ubiquitination-dependent inactivation of c-Jun NH2-terminal kinase | journal = The Journal of Biological Chemistry | volume = 283 | issue = 51 | pages = 35783–8 | date = December 2008 | pmid = 18845538 | doi = 10.1074/jbc.M806860200 }}</ref> and
* [[SEPT8]]<ref name = pmid12909369>{{cite journal | vauthors = Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B | title = Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202) | journal = Gene | volume = 312 | issue =  | pages = 313–20 | date = July 2003 | pmid = 12909369 | doi = 10.1016/S0378-1119(03)00635-8 }}</ref><ref name = pmid12023038>{{cite journal | vauthors = Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B | title = Human septin-septin interaction: CDCrel-1 partners with KIAA0202 | journal = FEBS Letters | volume = 519 | issue = 1-3 | pages = 169–72 | date = May 2002 | pmid = 12023038 | doi = 10.1016/S0014-5793(02)02749-7 }}</ref>
* [[SEPT8]]<ref name = pmid12909369>{{cite journal | vauthors = Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B | title = Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202) | journal = Gene | volume = 312 | issue =  | pages = 313–20 | date = July 2003 | pmid = 12909369 | doi = 10.1016/S0378-1119(03)00635-8 }}</ref><ref name = pmid12023038>{{cite journal | vauthors = Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B | title = Human septin-septin interaction: CDCrel-1 partners with KIAA0202 | journal = FEBS Letters | volume = 519 | issue = 1-3 | pages = 169–72 | date = May 2002 | pmid = 12023038 | doi = 10.1016/S0014-5793(02)02749-7 }}</ref>


Line 22: Line 22:
* {{cite journal | vauthors = Megonigal MD, Rappaport EF, Jones DH, Williams TM, Lovett BD, Kelly KM, Lerou PH, Moulton T, Budarf ML, Felix CA | title = t(11;22)(q23;q11.2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 11 | pages = 6413–8 | date = May 1998 | pmid = 9600980 | pmc = 27754 | doi = 10.1073/pnas.95.11.6413 }}
* {{cite journal | vauthors = Megonigal MD, Rappaport EF, Jones DH, Williams TM, Lovett BD, Kelly KM, Lerou PH, Moulton T, Budarf ML, Felix CA | title = t(11;22)(q23;q11.2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 11 | pages = 6413–8 | date = May 1998 | pmid = 9600980 | pmc = 27754 | doi = 10.1073/pnas.95.11.6413 }}
* {{cite journal | vauthors = Hsu SC, Hazuka CD, Roth R, Foletti DL, Heuser J, Scheller RH | title = Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments | journal = Neuron | volume = 20 | issue = 6 | pages = 1111–22 | date = June 1998 | pmid = 9655500 | doi = 10.1016/S0896-6273(00)80493-6 }}
* {{cite journal | vauthors = Hsu SC, Hazuka CD, Roth R, Foletti DL, Heuser J, Scheller RH | title = Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments | journal = Neuron | volume = 20 | issue = 6 | pages = 1111–22 | date = June 1998 | pmid = 9655500 | doi = 10.1016/S0896-6273(00)80493-6 }}
* {{cite journal | vauthors = Caltagarone J, Rhodes J, Honer WG, Bowser R | title = Localization of a novel septin protein, hCDCrel-1, in neurons of human brain | journal = Neuroreport | volume = 9 | issue = 12 | pages = 2907–12 | date = August 1998 | pmid = 9760144 | doi = 10.1097/00001756-199808240-00042 }}
* {{cite journal | vauthors = Caltagarone J, Rhodes J, Honer WG, Bowser R | title = Localization of a novel septin protein, hCDCrel-1, in neurons of human brain | journal = NeuroReport | volume = 9 | issue = 12 | pages = 2907–12 | date = August 1998 | pmid = 9760144 | doi = 10.1097/00001756-199808240-00042 }}
* {{cite journal | vauthors = Beites CL, Xie H, Bowser R, Trimble WS | title = The septin CDCrel-1 binds syntaxin and inhibits exocytosis | journal = Nature Neuroscience | volume = 2 | issue = 5 | pages = 434–9 | date = May 1999 | pmid = 10321247 | doi = 10.1038/8100 }}
* {{cite journal | vauthors = Beites CL, Xie H, Bowser R, Trimble WS | title = The septin CDCrel-1 binds syntaxin and inhibits exocytosis | journal = Nature Neuroscience | volume = 2 | issue = 5 | pages = 434–9 | date = May 1999 | pmid = 10321247 | doi = 10.1038/8100 }}
* {{cite journal | vauthors = Zhang Y, Gao J, Chung KK, Huang H, Dawson VL, Dawson TM | title = Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 24 | pages = 13354–9 | date = November 2000 | pmid = 11078524 | pmc = 27228 | doi = 10.1073/pnas.240347797 }}
* {{cite journal | vauthors = Zhang Y, Gao J, Chung KK, Huang H, Dawson VL, Dawson TM | title = Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 24 | pages = 13354–9 | date = November 2000 | pmid = 11078524 | pmc = 27228 | doi = 10.1073/pnas.240347797 }}
Line 35: Line 35:
* {{cite journal | vauthors = Lehner B, Sanderson CM | title = A protein interaction framework for human mRNA degradation | journal = Genome Research | volume = 14 | issue = 7 | pages = 1315–23 | date = July 2004 | pmid = 15231747 | pmc = 442147 | doi = 10.1101/gr.2122004 }}
* {{cite journal | vauthors = Lehner B, Sanderson CM | title = A protein interaction framework for human mRNA degradation | journal = Genome Research | volume = 14 | issue = 7 | pages = 1315–23 | date = July 2004 | pmid = 15231747 | pmc = 442147 | doi = 10.1101/gr.2122004 }}
{{refend}}
{{refend}}


{{gene-22-stub}}
{{gene-22-stub}}

Revision as of 17:20, 19 August 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Septin-5 is a protein that in humans is encoded by the SEPT5 gene.[1][2][3]

Function

This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Two transcripts of this gene, a major one of 2.2 kb and a minor one of 3.5 kb, have been observed. The 2.2 kb form results from the utilization of a non-consensus polyA signal (AACAAT). In the absence of polyadenylation from this imperfect site, the consensus polyA signal of the downstream neighboring gene (GP1BB; platelet glycoprotein Ib) is used, resulting in the 3.5 kb transcript. An alternatively spliced transcript variant with a different 5' end has also been identified, but its full-length nature has not been completely determined.[3]

Interactions

SEPT5 has been shown to interact with:

References

  1. ↑ McKie JM, Sutherland HF, Harvey E, Kim UJ, Scambler PJ (November 1997). "A human gene similar to Drosophila melanogaster peanut maps to the DiGeorge syndrome region of 22q11". Human Genetics. 101 (1): 6–12. doi:10.1007/s004390050576. PMID 9385360.
  2. ↑ Yagi M, Zieger B, Roth GJ, Ware J (June 1998). "Structure and expression of the human septin gene HCDCREL-1". Gene. 212 (2): 229–36. doi:10.1016/S0378-1119(98)00146-2. PMID 9611266.
  3. ↑ 3.0 3.1 "Entrez Gene: SEPT5 septin 5".
  4. ↑ Choi P, Snyder H, Petrucelli L, Theisler C, Chong M, Zhang Y, Lim K, Chung KK, Kehoe K, D'Adamio L, Lee JM, Cochran E, Bowser R, Dawson TM, Wolozin B (October 2003). "SEPT5_v2 is a parkin-binding protein". Brain Research. Molecular Brain Research. 117 (2): 179–89. doi:10.1016/S0169-328X(03)00318-8. PMID 14559152.
  5. ↑ Liu M, Aneja R, Sun X, Xie S, Wang H, Wu X, Dong JT, Li M, Joshi HC, Zhou J (December 2008). "Parkin regulates Eg5 expression by Hsp70 ubiquitination-dependent inactivation of c-Jun NH2-terminal kinase". The Journal of Biological Chemistry. 283 (51): 35783–8. doi:10.1074/jbc.M806860200. PMID 18845538.
  6. ↑ Bläser S, Jersch K, Hainmann I, Zieger W, Wunderle D, Busse A, Zieger B (July 2003). "Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202)". Gene. 312: 313–20. doi:10.1016/S0378-1119(03)00635-8. PMID 12909369.
  7. ↑ Bläser S, Jersch K, Hainmann I, Wunderle D, Zgaga-Griesz A, Busse A, Zieger B (May 2002). "Human septin-septin interaction: CDCrel-1 partners with KIAA0202". FEBS Letters. 519 (1–3): 169–72. doi:10.1016/S0014-5793(02)02749-7. PMID 12023038.

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=SEPT5&oldid=1518848"