Glucose-6-phosphate dehydrogenase deficiency diagnostic study of choice: Difference between revisions
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* Among the patients who present with clinical signs of [disease name], the [investigation name] is the most specific test for the diagnosis. | * Among the patients who present with clinical signs of [disease name], the [investigation name] is the most specific test for the diagnosis. | ||
* Among the patients who present with clinical signs of [disease name], the [investigation name] is the most sensitive test for diagnosis. | * Among the patients who present with clinical signs of [disease name], the [investigation name] is the most sensitive test for diagnosis. | ||
Among the patients who present with clinical signs of [disease name], the [investigation name] is the most efficient test for diagnosis. | |||
==== The comparison of various diagnostic studies for [disease name] ==== | ==== The comparison of various diagnostic studies for [disease name] ==== | ||
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__NOTOC__ | __NOTOC__ | ||
{{Glucose-6-phosphate dehydrogenase deficiency}} | {{Glucose-6-phosphate dehydrogenase deficiency}} | ||
Other standard tests are DNA testing and sequencing of the G6PD gene.<ref name="pmid29262208">{{cite journal |vauthors=Richardson SR, O'Malley GF |title= |journal= |volume= |issue= |pages= |date= |pmid=29262208 |doi= |url=}}</ref>{{CMG}}; {{AE}}{{MA}} [mailto:malihash@bidmc.harvard.edu] [mailto:malihash@bidmc.harvard.edu] [mailto:malihash@bidmc.harvard.edu] [mailto:malihash@bidmc.harvard.edu] | Other standard tests are DNA testing and sequencing of the G6PD gene.<ref name="pmid29262208">{{cite journal |vauthors=Richardson SR, O'Malley GF |title= |journal= |volume= |issue= |pages= |date= |pmid=29262208 |doi= |url=}}</ref>{{CMG}}; {{AE}} {{MA}} [mailto:malihash@bidmc.harvard.edu] [mailto:malihash@bidmc.harvard.edu] [mailto:malihash@bidmc.harvard.edu] [mailto:malihash@bidmc.harvard.edu] | ||
== Overview == | == Overview == | ||
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===== Diagnostic results ===== | ===== Diagnostic results ===== | ||
The following result of Beutler fluorescent spot testis is confirmatory of G6PD deficiency. | |||
* No fluorescence under ultraviolet light. False negative result in active hemolysis, so this test is done 2-3 weeks after hemolysis. | |||
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Revision as of 19:54, 27 August 2018
Xyz Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Glucose-6-phosphate dehydrogenase deficiency diagnostic study of choice On the Web |
American Roentgen Ray Society Images of Glucose-6-phosphate dehydrogenase deficiency diagnostic study of choice |
FDA on Glucose-6-phosphate dehydrogenase deficiency diagnostic study of choice |
CDC on Glucose-6-phosphate dehydrogenase deficiency diagnostic study of choice |
Glucose-6-phosphate dehydrogenase deficiency diagnostic study of choice in the news |
Blogs on Glucose-6-phosphate dehydrogenase deficiency diagnostic study of choice |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Diagnostic Study of Choice
Study of choice
[Name of the investigation] is the gold standard test for the diagnosis of [disease name].
OR
The following result of [gold standard test] is confirmatory of [disease name]:
- [Result 1]
- [Result 2]
OR
[Name of the investigation] must be performed when:
- The patient presents with [symptom/sign 1], [symptom/sign 2], and [symptom/sign 3].
- A [name of test] is positive for [sign 1], [sign 2], and [sign 3] in the patient.
OR
[Name of the investigation] is the gold standard test for the diagnosis of [disease name].
OR
The diagnostic study of choice for [disease name] is [name of the investigation].
OR
There is no single diagnostic study of choice for the diagnosis of [disease name].
OR
There is no single diagnostic study of choice for the diagnosis of [disease name], but [disease name] can be diagnosed based on [name of the investigation 1] and [name of the investigation 2].
OR
[Disease name] is primarily diagnosed based on the clinical presentation.
OR
Investigations:
- Among the patients who present with clinical signs of [disease name], the [investigation name] is the most specific test for the diagnosis.
- Among the patients who present with clinical signs of [disease name], the [investigation name] is the most sensitive test for diagnosis.
Among the patients who present with clinical signs of [disease name], the [investigation name] is the most efficient test for diagnosis.
The comparison of various diagnostic studies for [disease name]
Test | Sensitivity | Specificity |
---|---|---|
Test 1 | ...% | ...% |
Test 2 | ...% | ...% |
[Name of test with higher sensitivity and specificity] is the preferred investigation based on the sensitivity and specificity
Diagnostic results
The following finding(s) on performing [investigation name] is(are) confirmatory for [disease name]:
- [Finding 1]
- [Finding 2]
Sequence of Diagnostic Studies
The [name of investigation] must be performed when:
- The patient presented with symptoms/signs 1, 2, and 3 as the first step of diagnosis.
- A positive [test] is detected in the patient, to confirm the diagnosis.
OR
The various investigations must be performed in the following order:
- [Initial investigation]
- [2nd investigation]
Name of Diagnostic Criteria
It is recommended that you include the criteria in a table. Make sure you always cite the source of the content and whether the table has been adapted from another source.
[Disease name] is primarily diagnosed based on clinical presentation. There are no established criteria for the diagnosis of [disease name].
OR
There is no single diagnostic study of choice for [disease name], though [disease name] may be diagnosed based on [name of criteria] established by [...].
OR
The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].
OR
The diagnosis of [disease name] is based on the [criteria name] criteria, which includes [criterion 1], [criterion 2], and [criterion 3].
OR
[Disease name] may be diagnosed at any time if one or more of the following criteria are met:
- Criteria 1
- Criteria 2
- Criteria 3
OR
IF there are clear, established diagnostic criteria
The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].
OR
The diagnosis of [disease name] is based on the [criteria name] criteria, which include [criterion 1], [criterion 2], and [criterion 3].
OR
The diagnosis of [disease name] is based on the [definition name] definition, which includes [criterion 1], [criterion 2], and [criterion 3].
OR
IF there are no established diagnostic criteria
There are no established criteria for the diagnosis of [disease name].
References
Glucose-6-phosphate dehydrogenase deficiency Microchapters |
Differentiating Glucose-6-phosphate dehydrogenase deficiency from other Diseases |
---|
Diagnosis |
Treatment |
Case Studies |
Glucose-6-phosphate dehydrogenase deficiency diagnostic study of choice On the Web |
American Roentgen Ray Society Images of Glucose-6-phosphate dehydrogenase deficiency diagnostic study of choice |
FDA on Glucose-6-phosphate dehydrogenase deficiency diagnostic study of choice |
CDC on Glucose-6-phosphate dehydrogenase deficiency diagnostic study of choice |
Glucose-6-phosphate dehydrogenase deficiency diagnostic study of choice in the news |
Blogs on Glucose-6-phosphate dehydrogenase deficiency diagnostic study of choice |
Directions to Hospitals Treating Glucose-6-phosphate dehydrogenase deficiency |
Other standard tests are DNA testing and sequencing of the G6PD gene.[1]Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [3] [4] [5] [6] [7]
Overview
Diagnostic Study of Choice
Study of choice
Testing for G6PD deficiency may be done in the following settings:[2]
- Neonatal jaundice
- Unexplained hemolytic anemia
- High risk patients before administration oxidant medications.
- Asymptomatic family members
Beutler fluorescent spot test is the gold standard test for the diagnosis of G6PD deficiency. This test detects NADPH produced by G6PD under ultraviolet light.[1]
DNA testing and sequencing of the G6PD gene
Diagnostic results
The following result of Beutler fluorescent spot testis is confirmatory of G6PD deficiency.
- No fluorescence under ultraviolet light. False negative result in active hemolysis, so this test is done 2-3 weeks after hemolysis.
Test | Sensitivity | Specificity |
---|---|---|
Test 1 | ...% | ...% |
Test 2 | ...% | ...% |
[Name of test with higher sensitivity and specificity] is the preferred investigation based on the sensitivity and specificity
Diagnostic results
The following finding(s) on performing [investigation name] is(are) confirmatory for [disease name]:
- [Finding 1]
- [Finding 2]
Sequence of Diagnostic Studies
The [name of investigation] must be performed when:
- The patient presented with symptoms/signs 1, 2, and 3 as the first step of diagnosis.
- A positive [test] is detected in the patient, to confirm the diagnosis.
OR
The various investigations must be performed in the following order:
- [Initial investigation]
- [2nd investigation]