Thrombotic thrombocytopenic purpura diagnostic study of choice: Difference between revisions
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== Overview == | == Overview == | ||
== Study of choice == | == Study of choice == | ||
Complete blood count (CBC) with platelet count | * Complete blood count (CBC) with platelet count | ||
* Review of the peripheral blood smear | |||
Review of the peripheral blood smear | * Serum electrolytes and creatinine | ||
* Serum lactate dehydrogenase (LDH) | |||
Serum electrolytes and creatinine | * Serum bilirubin level | ||
* Coagulation testing ( PT, aPTT, fibrinogen, D-dimer) | |||
Serum lactate dehydrogenase (LDH) | * Serum haptoglobin level | ||
* Direct antiglobulin (Coombs) test (DAT) | |||
Serum bilirubin level | * ADAMTS13 activity and inhibitor testing | ||
* Stool exam | |||
Coagulation testing ( PT, aPTT, fibrinogen, D-dimer) | <br> | ||
==PLASMIC score == | |||
Serum haptoglobin level | {{#Widget:PLASMIC score}} | ||
<br> | |||
Direct antiglobulin (Coombs) test (DAT) | '''<big>Risk of ADAMPTS13 deficiency</big>''' '''<big>in adults with suspected TTP</big>''' <ref name="JammeRondeau2017">{{cite journal|last1=Jamme|first1=Matthieu|last2=Rondeau|first2=Eric|title=The PLASMIC score for thrombotic thrombocytopenic purpura|journal=The Lancet Haematology|volume=4|issue=4|year=2017|pages=e148–e149|issn=23523026|doi=10.1016/S2352-3026(17)30024-8}}</ref>'''<big>:</big>''' | ||
* '''Low-risk''' = 0 to 4 points | |||
ADAMTS13 activity and inhibitor testing | * '''Intermediate risk''' = 5 points | ||
* '''High-risk''' = 6 to 7 points | |||
==References== | |||
Revision as of 15:59, 23 August 2018
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Saeedeh Kowsarnia M.D.[2]
Overview
Study of choice
- Complete blood count (CBC) with platelet count
- Review of the peripheral blood smear
- Serum electrolytes and creatinine
- Serum lactate dehydrogenase (LDH)
- Serum bilirubin level
- Coagulation testing ( PT, aPTT, fibrinogen, D-dimer)
- Serum haptoglobin level
- Direct antiglobulin (Coombs) test (DAT)
- ADAMTS13 activity and inhibitor testing
- Stool exam
PLASMIC score
Risk of ADAMPTS13 deficiency in adults with suspected TTP [1]:
- Low-risk = 0 to 4 points
- Intermediate risk = 5 points
- High-risk = 6 to 7 points
References
- ↑ Jamme, Matthieu; Rondeau, Eric (2017). "The PLASMIC score for thrombotic thrombocytopenic purpura". The Lancet Haematology. 4 (4): e148–e149. doi:10.1016/S2352-3026(17)30024-8. ISSN 2352-3026.