Sandbox: sadaf: Difference between revisions

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|Predictable, dose-dependent myelosuppression
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!folate, vitamin B12, copper
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|an autoimmune mechanism
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| align="center" style="background:#F5F5F5;" + |Mild
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! rowspan="3" |'''Thrombotic microangiopathy (TMA)'''
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!Thrombotic thrombocytopenic purpura (TTP)
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!Hemolytic uremic syndrome (HUS)
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!Drug-induced TMA (DITMA)
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! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category
! rowspan="4" |'''Bone marrow disorders'''
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!Myelodysplastic syndromes
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!Aplastic anemia
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!Acute leukemia
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!Paroxysmal nocturnal hemoglobinuria (PNH)
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<references />
<references />

Revision as of 18:20, 7 August 2018

Thrombocytopenia Differential Diagnosis

Differentiating the diseases that can cause thrombocytopenia:

Category Condition Clinical manifestations Para−clinical findings Gold standard Associated findings
Symptoms Signs
Lab Findings Imaging
Severity Fever Bleeding BP Other CBC PBS Coagulopathy
Mechanism
Infectious diseases Gestational thrombocytopenia
Chronic liver disease
portal hypertension
Hypersplenism
Immune thrombocytopenia Antibody-mediated platelet destruction Moderate to severe - Diagnosis of exclusion
Congenital platelet disorders MYH-9 related disorders
Bernard-Soulier syndrome
Gray platelet syndrome
Wiskott-Aldrich syndrome
Thrombocytopenia with absent radius (TAR) syndrome
Alport syndrome
Von Willebrand disease
Category
Infection Viral infections such as:

rubella, mumps, varicella, parvovirus, hepatitis C, and Epstein-Barr virus

HIV
  • Direct toxicity to megakaryocytes
  • An ITP-like condition called primary HIV-associated thrombocytopenia (PHAT)
  • Secondary opportunistic infections
Sepsis Direct bone marrow suppression
Helicobacter pylori Immune thrombocytopenia
leptospirosis, brucellosis, anaplasmosis, and other tick-borne infections
Intracellular parasites Malaria
Babesiosis
Medications Drug-induced immune thrombocytopenia
  • Antibiotics
    • Sulfonamides
    • Ampicillin
    • Piperacillin
    • Vancomycin
    • Rifampin
  • Older antiepileptic agents
    • carbamazepine
    • Phenytoin
  • Quinine
 Occurrence of drug-dependent, platelet-reactive antibodies
Heparin-induced thrombocytopenia
Cytotoxic chemotherapy
Radiation therapy Predictable, dose-dependent myelosuppression
OTC agents Quinine-containing beverages
Alcohol
Malignancy
Nutrient deficiencies folate, vitamin B12, copper an autoimmune mechanism Mild
Thrombotic microangiopathy (TMA) Thrombotic thrombocytopenic purpura (TTP)
Hemolytic uremic syndrome (HUS)
Drug-induced TMA (DITMA)
Bone marrow disorders Myelodysplastic syndromes
Aplastic anemia
Acute leukemia
Paroxysmal nocturnal hemoglobinuria (PNH)
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