Myeloproliferative neoplasm causes: Difference between revisions

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Revision as of 18:48, 9 June 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2] Shyam Patel [3]

Overview

Myeloproliferative neoplasm is caused by mutations in various genes. Different gene mutations are responsible for each of the 8 subtypes of myeloproliferative neoplasms. ^[1]^[2]^[1]

Causes


Myeloproliferative neoplasm subtype	Causative gene mutation

Polycythemia vera	JAK2 V617F CALR MPL
Essential thrombocythemia	JAK2 V617F CALR MPL
Primary myelofibrosis	JAK2 V617F CALR MPL
Chronic myeloid leukemia	BCR-ABL
Chronic neutrophilic leukemia	CSF3R
Chronic eosinophilic leukemia	FIL1L1-PDGFRA PDGFRB FGFR1 PCM1-JAK2
Myeloproliferative neoplasm, unclassifiable	Variable
Mastocytosis	c-kit D816V

References

↑ ^1.0 ^1.1 Ganfyd. Polycythaemia vera 2015.http://www.ganfyd.org/index.php?title=Polycythemia_vera
↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID http://dx.doi.org/10.1182/blood-2013-11-538983 Check |pmid= value (help).

Template:WH Template:WS

[ganfyd-1] 1.0 ^1.1 Ganfyd. Polycythaemia vera 2015.http://www.ganfyd.org/index.php?title=Polycythemia_vera

[pmidhttp://dx.doi.org/10.1182/blood-2013-11-538983-2] Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID http://dx.doi.org/10.1182/blood-2013-11-538983 Check |pmid= value (help).

[1]

[2]

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Myeloproliferative disease}}
-{{CMG}}{{AE}} {{MJK}}
+{{CMG}}{{AE}} {{MJK}} {{shyam}}
 ==Overview==
-Myeloproliferative neoplasm is caused by a mutation in the ''[[BCR]]-[[ABL]]'', [[Janus kinase 2]], and [[calreticulin]] genes.<ref name="ganfyd">Ganfyd. Polycythaemia vera 2015.http://www.ganfyd.org/index.php?title=Polycythemia_vera</ref><ref name="pmidhttp://dx.doi.org/10.1182/blood-2013-11-538983">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=http://dx.doi.org/10.1182/blood-2013-11-538983 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10  }} </ref><ref name="ganfyd">Ganfyd. Myelofibrosis2015.http://www.ganfyd.org/index.php?title=Primary_myelofibrosis</ref>
+Myeloproliferative neoplasm is caused by mutations in various genes. Different gene mutations are responsible for each of the 8 subtypes of myeloproliferative neoplasms. <ref name="ganfyd">Ganfyd. Polycythaemia vera 2015.http://www.ganfyd.org/index.php?title=Polycythemia_vera</ref><ref name="pmidhttp://dx.doi.org/10.1182/blood-2013-11-538983">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=http://dx.doi.org/10.1182/blood-2013-11-538983 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10  }} </ref><ref name="ganfyd">Ganfyd. Myelofibrosis2015.http://www.ganfyd.org/index.php?title=Primary_myelofibrosis</ref>
 ==Causes==
-Myeloproliferative neoplasm may be caused by a mutation in the following genes:
+{| style="border: 0px; font-size: 90%; margin: 3px; width: 600px" align=center
+|valign=top|
+|+
+! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Myeloproliferative neoplasm subtype}}
+! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Causative gene mutation}}
+|-
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
+Polycythemia vera
+| style="padding: 5px 5px; background: #F5F5F5;" |
+''JAK2'' ''V617F''
+''CALR''
+''MPL''
+|-
+| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
+Essential thrombocythemia
+| style="padding: 5px 5px; background: #F5F5F5;" |
+''JAK2'' ''V617F''
+''CALR''
+''MPL''
+|-
+| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
+Primary myelofibrosis
+| style="padding: 5px 5px; background: #F5F5F5;" |
+''JAK2'' ''V617F''
+''CALR''
+''MPL''
+|-
+| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
+Chronic myeloid leukemia
+| style="padding: 5px 5px; background: #F5F5F5;" |
+''BCR-ABL''
+|-
+| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
+Chronic neutrophilic leukemia
+| style="padding: 5px 5px; background: #F5F5F5;" |
+''CSF3R''
+|-
+| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
+Chronic eosinophilic leukemia
+| style="padding: 5px 5px; background: #F5F5F5;" |
+''FIL1L1-PDGFRA''
+''PDGFRB''
+''FGFR1''
+''PCM1-JAK2''
+|-
+| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
+Myeloproliferative neoplasm, unclassifiable
+| style="padding: 5px 5px; background: #F5F5F5;" |
+Variable
+|-
+| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
+Mastocytosis
+| style="padding: 5px 5px; background: #F5F5F5;" |
+''c-kit'' ''D816V''
+|}
 ==References==

Myeloproliferative neoplasm causes: Difference between revisions

Revision as of 18:48, 9 June 2018

Overview

Causes

References

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