Sjögren's syndrome laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
*Laboratory findings consistent with the diagnosis of Sjögren's syndrome include: | *Laboratory findings consistent with the diagnosis of Sjögren's syndrome include:<ref name="pmid24162151">{{cite journal |vauthors=Ramos-Casals M, Brito-Zerón P, Solans R, Camps MT, Casanovas A, Sopeña B, Díaz-López B, Rascón FJ, Qanneta R, Fraile G, Pérez-Alvarez R, Callejas JL, Ripoll M, Pinilla B, Akasbi M, Fonseca E, Canora J, Nadal ME, de la Red G, Fernández-Regal I, Jiménez-Heredia I, Bosch JA, Ayala MD, Morera-Morales L, Maure B, Mera A, Ramentol M, Retamozo S, Kostov B |title=Systemic involvement in primary Sjogren's syndrome evaluated by the EULAR-SS disease activity index: analysis of 921 Spanish patients (GEAS-SS Registry) |journal=Rheumatology (Oxford) |volume=53 |issue=2 |pages=321–31 |date=February 2014 |pmid=24162151 |doi=10.1093/rheumatology/ket349 |url=}}</ref><ref name="pmid23436818">{{cite journal |vauthors=Yazdany J, Schmajuk G, Robbins M, Daikh D, Beall A, Yelin E, Barton J, Carlson A, Margaretten M, Zell J, Gensler LS, Kelly V, Saag K, King C |title=Choosing wisely: the American College of Rheumatology's Top 5 list of things physicians and patients should question |journal=Arthritis Care Res (Hoboken) |volume=65 |issue=3 |pages=329–39 |date=March 2013 |pmid=23436818 |pmc=4106486 |doi=10.1002/acr.21930 |url=}}</ref><ref name="pmid26766898">{{cite journal |vauthors=Beckman KA, Luchs J, Milner MS |title=Making the diagnosis of Sjögren's syndrome in patients with dry eye |journal=Clin Ophthalmol |volume=10 |issue= |pages=43–53 |date=2016 |pmid=26766898 |pmc=4699514 |doi=10.2147/OPTH.S80043 |url=}}</ref><ref name="pmid28367079">{{cite journal |vauthors=Both T, Dalm VA, van Hagen PM, van Daele PL |title=Reviewing primary Sjögren's syndrome: beyond the dryness - From pathophysiology to diagnosis and treatment |journal=Int J Med Sci |volume=14 |issue=3 |pages=191–200 |date=2017 |pmid=28367079 |pmc=5370281 |doi=10.7150/ijms.17718 |url=}}</ref> | ||
**Elevated erythrocyte sedimentation rate (ESR) | **Elevated erythrocyte sedimentation rate (ESR) | ||
**Anemia | **Anemia | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
- Laboratory findings consistent with the diagnosis of Sjögren's syndrome include:[1][2][3][4]
- Elevated erythrocyte sedimentation rate (ESR)
- Anemia
- Leukopenia
- Thrombocytopenia
- Eosinophilia
- Hypergammaglobulinemia
- Presence of anti-SSA/Ro, anti-SSB/La
- Presence of rheumatoid factor (RF)
- Presence of anti–alpha-fodrin antibody (diagnostic marker of juvenile Sjögren's syndrome)
- Increasing Creatinine (Cr) level
- Proteinuria or cellular casts and hematuria
References
- ↑ Ramos-Casals M, Brito-Zerón P, Solans R, Camps MT, Casanovas A, Sopeña B, Díaz-López B, Rascón FJ, Qanneta R, Fraile G, Pérez-Alvarez R, Callejas JL, Ripoll M, Pinilla B, Akasbi M, Fonseca E, Canora J, Nadal ME, de la Red G, Fernández-Regal I, Jiménez-Heredia I, Bosch JA, Ayala MD, Morera-Morales L, Maure B, Mera A, Ramentol M, Retamozo S, Kostov B (February 2014). "Systemic involvement in primary Sjogren's syndrome evaluated by the EULAR-SS disease activity index: analysis of 921 Spanish patients (GEAS-SS Registry)". Rheumatology (Oxford). 53 (2): 321–31. doi:10.1093/rheumatology/ket349. PMID 24162151.
- ↑ Yazdany J, Schmajuk G, Robbins M, Daikh D, Beall A, Yelin E, Barton J, Carlson A, Margaretten M, Zell J, Gensler LS, Kelly V, Saag K, King C (March 2013). "Choosing wisely: the American College of Rheumatology's Top 5 list of things physicians and patients should question". Arthritis Care Res (Hoboken). 65 (3): 329–39. doi:10.1002/acr.21930. PMC 4106486. PMID 23436818.
- ↑ Beckman KA, Luchs J, Milner MS (2016). "Making the diagnosis of Sjögren's syndrome in patients with dry eye". Clin Ophthalmol. 10: 43–53. doi:10.2147/OPTH.S80043. PMC 4699514. PMID 26766898.
- ↑ Both T, Dalm VA, van Hagen PM, van Daele PL (2017). "Reviewing primary Sjögren's syndrome: beyond the dryness - From pathophysiology to diagnosis and treatment". Int J Med Sci. 14 (3): 191–200. doi:10.7150/ijms.17718. PMC 5370281. PMID 28367079.