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==Overview==
==Overview==
Tabes dorsalis is now very rare because syphilis is usually treated early in the disease.
Tabes dorsalis is now very rare because [[syphilis]] is usually treated early in the disease.


In 2012, the [[incidence]] of [[syphilis]] was estimated to be 6 million cases worldwide. From year 2005 to 2014, the [[incidence]] of [[syphilis]] in the United States increased from 2.9 to 6.3 cases/100,000/year. The rate of reported cases increased by 15.1% between 2013 and 2014 in the United States. In 2012, the [[prevalence]] of syphilis was estimated to be approximately 18 million cases in men and women aged 15-29 worldwide. Among infected patients with [[Treponema pallidum]] only 3 to 5% develop [[neurosyphilis]] and only 5% of those individuals develop tabes dorsalis, 10–20 years later.
In 2012, the [[incidence]] of [[syphilis]] was estimated to be 6 million cases worldwide. From year 2005 to 2014, the [[incidence]] of [[syphilis]] in the United States increased from 2.9 to 6.3 cases/100,000/year. The rate of reported cases increased by 15.1% between 2013 and 2014 in the United States. In 2012, the [[prevalence]] of syphilis was estimated to be approximately 18 million cases in men and women aged 15-29 worldwide. Among infected patients with [[Treponema pallidum]] only 3 to 5% develop [[neurosyphilis]] and only 5% of those individuals develop tabes dorsalis, 10–20 years later.


== Epidemiology of syphilis and tabes dorsalis ==
== Epidemiology of syphilis and tabes dorsalis ==
Tabes dorsalis is now very rare because syphilis is usually treated early in the disease.
Tabes dorsalis is now very rare because [[syphilis]] is usually treated early in the disease.


In 2012, the [[incidence]] of [[syphilis]] was estimated to be 6 million cases worldwide. From year 2005 to 2014, the [[incidence]] of [[syphilis]] in the United States increased from 2.9 to 6.3 cases/100,000/year. The rate of reported cases increased by 15.1% between 2013 and 2014 in the United States.<ref name="CDC">https://www.cdc.gov/std/stats14/surv-2014-print.pdf Accessed on September 16, 2016</ref> [[Syphilis]] incidence increased in every region of the Untied States in 2014, with the highest rate in the West and lowest rate in the Midwest. In 2012, the [[prevalence]] of syphilis was estimated to be approximately 18 million cases in men and women aged 15-29 worldwide.<ref name="pmid26646541">{{cite journal| author=Newman L, Rowley J, Vander Hoorn S, Wijesooriya NS, Unemo M, Low N et al.| title=Global Estimates of the Prevalence and Incidence of Four Curable Sexually Transmitted Infections in 2012 Based on Systematic Review and Global Reporting. | journal=PLoS One | year= 2015 | volume= 10 | issue= 12 | pages= e0143304 | pmid=26646541 | doi=10.1371/journal.pone.0143304 | pmc=4672879 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26646541  }} </ref> The incidence and prevalence of [[syphilis]] may be affected by age, gender, race, sexual behavior and geographical distribution. Among infected patients with [[Treponema pallidum]] only 3 to 5% develop [[neurosyphilis]] and only 5% of those individuals develop tabes dorsalis, 10–20 years later.<ref name="CDC">https://www.cdc.gov/std/stats14/surv-2014-print.pdf Accessed on September 16, 2016</ref><ref name="pmid23403598">{{cite journal| author=Satterwhite CL, Torrone E, Meites E, Dunne EF, Mahajan R, Ocfemia MC et al.| title=Sexually transmitted infections among US women and men: prevalence and incidence estimates, 2008. | journal=Sex Transm Dis | year= 2013 | volume= 40 | issue= 3 | pages= 187-93 | pmid=23403598 | doi=10.1097/OLQ.0b013e318286bb53 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23403598  }} </ref><ref name="WHO2012">http://apps.who.int/iris/bitstream/10665/85376/1/9789241505895_eng.pdf?=1 Accessed on September 16, 2016</ref><ref name="pmid23049658">{{cite journal| author=Purcell DW, Johnson CH, Lansky A, Prejean J, Stein R, Denning P et al.| title=Estimating the population size of men who have sex with men in the United States to obtain HIV and syphilis rates. | journal=Open AIDS J | year= 2012 | volume= 6 | issue=  | pages= 98-107 | pmid=23049658 | doi=10.2174/1874613601206010098 | pmc=3462414 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23049658  }} </ref><ref name="pmid17463387">{{cite journal| author=Heffelfinger JD, Swint EB, Berman SM, Weinstock HS| title=Trends in primary and secondary syphilis among men who have sex with men in the United States. | journal=Am J Public Health | year= 2007 | volume= 97 | issue= 6 | pages= 1076-83 | pmid=17463387 | doi=10.2105/AJPH.2005.070417 | pmc=1874206 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17463387  }} </ref><ref name="pmid6893897">{{cite journal| author=Judson FN, Penley KA, Robinson ME, Smith JK| title=Comparative prevalence rates of sexually transmitted diseases in heterosexual and homosexual men. | journal=Am J Epidemiol | year= 1980 | volume= 112 | issue= 6 | pages= 836-43 | pmid=6893897 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6893897  }} </ref><ref name="pmid22330117">{{cite journal| author=Pandey S| title=Magnetic resonance imaging of the spinal cord in a man with tabes dorsalis. | journal=J Spinal Cord Med | year= 2011 | volume= 34 | issue= 6 | pages= 609-11 | pmid=22330117 | doi=10.1179/2045772311Y.0000000041 | pmc=3237288 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22330117  }} </ref>
In 2012, the [[incidence]] of [[syphilis]] was estimated to be 6 million cases worldwide. From year 2005 to 2014, the [[incidence]] of [[syphilis]] in the United States increased from 2.9 to 6.3 cases/100,000/year. The rate of reported cases increased by 15.1% between 2013 and 2014 in the United States.<ref name="CDC">https://www.cdc.gov/std/stats14/surv-2014-print.pdf Accessed on September 16, 2016</ref> [[Syphilis]] incidence increased in every region of the Untied States in 2014, with the highest rate in the West and lowest rate in the Midwest. In 2012, the [[prevalence]] of syphilis was estimated to be approximately 18 million cases in men and women aged 15-29 worldwide.<ref name="pmid26646541">{{cite journal| author=Newman L, Rowley J, Vander Hoorn S, Wijesooriya NS, Unemo M, Low N et al.| title=Global Estimates of the Prevalence and Incidence of Four Curable Sexually Transmitted Infections in 2012 Based on Systematic Review and Global Reporting. | journal=PLoS One | year= 2015 | volume= 10 | issue= 12 | pages= e0143304 | pmid=26646541 | doi=10.1371/journal.pone.0143304 | pmc=4672879 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26646541  }} </ref> The [[incidence]] and [[prevalence]] of [[syphilis]] may be affected by age, gender, race, sexual behavior and geographical distribution. Among infected patients with [[Treponema pallidum]] only 3 to 5% develop [[neurosyphilis]] and only 5% of those individuals develop tabes dorsalis, 10–20 years later.<ref name="CDC">https://www.cdc.gov/std/stats14/surv-2014-print.pdf Accessed on September 16, 2016</ref><ref name="pmid23403598">{{cite journal| author=Satterwhite CL, Torrone E, Meites E, Dunne EF, Mahajan R, Ocfemia MC et al.| title=Sexually transmitted infections among US women and men: prevalence and incidence estimates, 2008. | journal=Sex Transm Dis | year= 2013 | volume= 40 | issue= 3 | pages= 187-93 | pmid=23403598 | doi=10.1097/OLQ.0b013e318286bb53 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23403598  }} </ref><ref name="WHO2012">http://apps.who.int/iris/bitstream/10665/85376/1/9789241505895_eng.pdf?=1 Accessed on September 16, 2016</ref><ref name="pmid23049658">{{cite journal| author=Purcell DW, Johnson CH, Lansky A, Prejean J, Stein R, Denning P et al.| title=Estimating the population size of men who have sex with men in the United States to obtain HIV and syphilis rates. | journal=Open AIDS J | year= 2012 | volume= 6 | issue=  | pages= 98-107 | pmid=23049658 | doi=10.2174/1874613601206010098 | pmc=3462414 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23049658  }} </ref><ref name="pmid17463387">{{cite journal| author=Heffelfinger JD, Swint EB, Berman SM, Weinstock HS| title=Trends in primary and secondary syphilis among men who have sex with men in the United States. | journal=Am J Public Health | year= 2007 | volume= 97 | issue= 6 | pages= 1076-83 | pmid=17463387 | doi=10.2105/AJPH.2005.070417 | pmc=1874206 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17463387  }} </ref><ref name="pmid6893897">{{cite journal| author=Judson FN, Penley KA, Robinson ME, Smith JK| title=Comparative prevalence rates of sexually transmitted diseases in heterosexual and homosexual men. | journal=Am J Epidemiol | year= 1980 | volume= 112 | issue= 6 | pages= 836-43 | pmid=6893897 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6893897  }} </ref><ref name="pmid22330117">{{cite journal| author=Pandey S| title=Magnetic resonance imaging of the spinal cord in a man with tabes dorsalis. | journal=J Spinal Cord Med | year= 2011 | volume= 34 | issue= 6 | pages= 609-11 | pmid=22330117 | doi=10.1179/2045772311Y.0000000041 | pmc=3237288 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22330117  }} </ref>


==References==
==References==

Revision as of 14:59, 12 February 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Mohamadmostafa Jahansouz M.D.[2] Associate Editor(s)-in-Chief: Aysha Anwar, M.B.B.S[3]; Nate Michalak, B.A.

Overview

Tabes dorsalis is now very rare because syphilis is usually treated early in the disease.

In 2012, the incidence of syphilis was estimated to be 6 million cases worldwide. From year 2005 to 2014, the incidence of syphilis in the United States increased from 2.9 to 6.3 cases/100,000/year. The rate of reported cases increased by 15.1% between 2013 and 2014 in the United States. In 2012, the prevalence of syphilis was estimated to be approximately 18 million cases in men and women aged 15-29 worldwide. Among infected patients with Treponema pallidum only 3 to 5% develop neurosyphilis and only 5% of those individuals develop tabes dorsalis, 10–20 years later.

Epidemiology of syphilis and tabes dorsalis

Tabes dorsalis is now very rare because syphilis is usually treated early in the disease.

In 2012, the incidence of syphilis was estimated to be 6 million cases worldwide. From year 2005 to 2014, the incidence of syphilis in the United States increased from 2.9 to 6.3 cases/100,000/year. The rate of reported cases increased by 15.1% between 2013 and 2014 in the United States.[1] Syphilis incidence increased in every region of the Untied States in 2014, with the highest rate in the West and lowest rate in the Midwest. In 2012, the prevalence of syphilis was estimated to be approximately 18 million cases in men and women aged 15-29 worldwide.[2] The incidence and prevalence of syphilis may be affected by age, gender, race, sexual behavior and geographical distribution. Among infected patients with Treponema pallidum only 3 to 5% develop neurosyphilis and only 5% of those individuals develop tabes dorsalis, 10–20 years later.[1][3][4][5][6][7][8]

References

  1. 1.0 1.1 https://www.cdc.gov/std/stats14/surv-2014-print.pdf Accessed on September 16, 2016
  2. Newman L, Rowley J, Vander Hoorn S, Wijesooriya NS, Unemo M, Low N; et al. (2015). "Global Estimates of the Prevalence and Incidence of Four Curable Sexually Transmitted Infections in 2012 Based on Systematic Review and Global Reporting". PLoS One. 10 (12): e0143304. doi:10.1371/journal.pone.0143304. PMC 4672879. PMID 26646541.
  3. Satterwhite CL, Torrone E, Meites E, Dunne EF, Mahajan R, Ocfemia MC; et al. (2013). "Sexually transmitted infections among US women and men: prevalence and incidence estimates, 2008". Sex Transm Dis. 40 (3): 187–93. doi:10.1097/OLQ.0b013e318286bb53. PMID 23403598.
  4. http://apps.who.int/iris/bitstream/10665/85376/1/9789241505895_eng.pdf?=1 Accessed on September 16, 2016
  5. Purcell DW, Johnson CH, Lansky A, Prejean J, Stein R, Denning P; et al. (2012). "Estimating the population size of men who have sex with men in the United States to obtain HIV and syphilis rates". Open AIDS J. 6: 98–107. doi:10.2174/1874613601206010098. PMC 3462414. PMID 23049658.
  6. Heffelfinger JD, Swint EB, Berman SM, Weinstock HS (2007). "Trends in primary and secondary syphilis among men who have sex with men in the United States". Am J Public Health. 97 (6): 1076–83. doi:10.2105/AJPH.2005.070417. PMC 1874206. PMID 17463387.
  7. Judson FN, Penley KA, Robinson ME, Smith JK (1980). "Comparative prevalence rates of sexually transmitted diseases in heterosexual and homosexual men". Am J Epidemiol. 112 (6): 836–43. PMID 6893897.
  8. Pandey S (2011). "Magnetic resonance imaging of the spinal cord in a man with tabes dorsalis". J Spinal Cord Med. 34 (6): 609–11. doi:10.1179/2045772311Y.0000000041. PMC 3237288. PMID 22330117.


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