ARHGEF6: Difference between revisions

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Revision as of 18:13, 29 August 2017

Rho guanine nucleotide exchange factor 6 is a protein that, in humans, is encoded by the ARHGEF6 gene.^[1]^[2]^[3]

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that catalyse the exchange of GDP for GTP in some Rho-family small GTPases. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.^[3]

References

↑ Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 (supplement)". DNA Res. 1 (5): 251–62. doi:10.1093/dnares/1.5.251. PMID 7584048.
↑ Manser E, Loo TH, Koh CG, Zhao ZS, Chen XQ, Tan L, Tan I, Leung T, Lim L (Jul 1998). "PAK kinases are directly coupled to the PIX family of nucleotide exchange factors". Mol Cell. 1 (2): 183–92. doi:10.1016/S1097-2765(00)80019-2. PMID 9659915.
↑ ^3.0 ^3.1 "Entrez Gene: ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6".

External links

Human ARHGEF6 genome location and ARHGEF6 gene details page in the UCSC Genome Browser.

Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
Ebinu JO, Bottorff DA, Chan EY, et al. (1998). "RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs". Science. 280 (5366): 1082–6. doi:10.1126/science.280.5366.1082. PMID 9582122.
Yntema HG, Hamel BC, Smits AP, et al. (1999). "Localisation of a gene for non-specific X linked mental retardation (MRX46) to Xq25-q26". J. Med. Genet. 35 (10): 801–5. doi:10.1136/jmg.35.10.801. PMC 1051453. PMID 9783701.
Yoshii S, Tanaka M, Otsuki Y, et al. (1999). "alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase". Oncogene. 18 (41): 5680–90. doi:10.1038/sj.onc.1202936. PMID 10523848.
Brown A, Wang X, Sawai E, Cheng-Mayer C (1999). "Activation of the PAK-related kinase by human immunodeficiency virus type 1 Nef in primary human peripheral blood lymphocytes and macrophages leads to phosphorylation of a PIX-p95 complex". J. Virol. 73 (12): 9899–907. PMC 113039. PMID 10559302.
Premont RT, Claing A, Vitale N, et al. (2000). "The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing". J. Biol. Chem. 275 (29): 22373–80. doi:10.1074/jbc.275.29.22373. PMID 10896954.
Kutsche K, Yntema H, Brandt A, et al. (2000). "Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation". Nat. Genet. 26 (2): 247–50. doi:10.1038/80002. PMID 11017088.
Lower KM, Gecz J (2001). "Characterization of ARHGEF6, a guanine nucleotide exchange factor for Rho GTPases and a candidate gene for X-linked mental retardation: mutation screening in Börjeson-Forssman-Lehmann syndrome and MRX27". Am. J. Med. Genet. 100 (1): 43–8. doi:10.1002/ajmg.1189. PMID 11337747.
Yoshii S, Tanaka M, Otsuki Y, et al. (2001). "Involvement of alpha-PAK-interacting exchange factor in the PAK1-c-Jun NH(2)-terminal kinase 1 activation and apoptosis induced by benzo[a]pyrene". Mol. Cell. Biol. 21 (20): 6796–807. doi:10.1128/MCB.21.20.6796-6807.2001. PMC 99857. PMID 11564864.
Vikis HG, Li W, Guan KL (2002). "The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding". Genes Dev. 16 (7): 836–45. doi:10.1101/gad.966402. PMC 186329. PMID 11937491.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Rosenberger G, Jantke I, Gal A, Kutsche K (2003). "Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling". Hum. Mol. Genet. 12 (2): 155–67. doi:10.1093/hmg/ddg019. PMID 12499396.
Flanders JA, Feng Q, Bagrodia S, et al. (2003). "The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins". FEBS Lett. 550 (1–3): 119–23. doi:10.1016/S0014-5793(03)00853-6. PMID 12935897.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Djordjevic T, Hess J, Herkert O, et al. (2005). "Rac regulates thrombin-induced tissue factor expression in pulmonary artery smooth muscle cells involving the nuclear factor-kappaB pathway". Antioxid. Redox Signal. 6 (4): 713–20. doi:10.1089/1523086041361703. PMID 15242552.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[pmid7584048-1] Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 (supplement)". DNA Res. 1 (5): 251–62. doi:10.1093/dnares/1.5.251. PMID 7584048.

[pmid9659915-2] Manser E, Loo TH, Koh CG, Zhao ZS, Chen XQ, Tan L, Tan I, Leung T, Lim L (Jul 1998). "PAK kinases are directly coupled to the PIX family of nucleotide exchange factors". Mol Cell. 1 (2): 183–92. doi:10.1016/S1097-2765(00)80019-2. PMID 9659915.

[entrez-3] 3.0 ^3.1 "Entrez Gene: ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Rho guanine nucleotide exchange factor 6''' is a [[protein]] that, in humans, is encoded by the ''ARHGEF6'' [[gene]].<ref name="pmid7584048">{{cite journal | vauthors = Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S | title = Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 (supplement) | journal = DNA Res | volume = 1 | issue = 5 | pages = 251–62 |date=Dec 1995 | pmid = 7584048 | pmc =  | doi =10.1093/dnares/1.5.251  }}</ref><ref name="pmid9659915">{{cite journal | vauthors = Manser E, Loo TH, Koh CG, Zhao ZS, Chen XQ, Tan L, Tan I, Leung T, Lim L | title = PAK kinases are directly coupled to the PIX family of nucleotide exchange factors | journal = Mol Cell | volume = 1 | issue = 2 | pages = 183–92 |date=Jul 1998 | pmid = 9659915 | pmc =  | doi =10.1016/S1097-2765(00)80019-2  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9459| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image = PBB_Protein_ARHGEF6_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ujy.
- | PDB = {{PDB2|1ujy}}, {{PDB2|1wyr}}
- | Name = Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
- | HGNCid = 685
- | Symbol = ARHGEF6
- | AltSymbols =; COOL2; Cool-2; KIAA0006; MRX46; PIXA; alpha-PIX; alphaPIX
- | OMIM = 300267
- | ECnumber =
- | Homologene = 3561
- | MGIid = 1920591
-  | GeneAtlas_image1 = PBB_GE_ARHGEF6_209539_at_tn.png
-  | Function = {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005089 |text = Rho guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}}
- | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
- | Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007254 |text = JNK cascade}} {{GNF_GO|id=GO:0035023 |text = regulation of Rho protein signal transduction}}
-  | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 9459
-    | Hs_Ensembl = ENSG00000129675
-    | Hs_RefseqProtein = NP_004831
-    | Hs_RefseqmRNA = NM_004840
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = X
-    | Hs_GenLoc_start = 135575372
-    | Hs_GenLoc_end = 135691913
-    | Hs_Uniprot = Q15052
-    | Mm_EntrezGene = 73341
-    | Mm_Ensembl = ENSMUSG00000031133
-    | Mm_RefseqmRNA = NM_152801
-    | Mm_RefseqProtein = NP_690014
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = X
-    | Mm_GenLoc_start = 53578271
-    | Mm_GenLoc_end = 53685513
-    | Mm_Uniprot = Q8K4I3
-  }}
-}}
-'''Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6''', also known as '''ARHGEF6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9459| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.<ref name="entrez">{{cite web | title = Entrez Gene: ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9459| accessdate = }}</ref>
+| summary_text = Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that catalyse the exchange of GDP for GTP in some Rho-family small GTPases. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.<ref name="entrez"/>
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
+==External links==
+* {{UCSC gene info|ARHGEF6}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Nomura N, Miyajima N, Sazuka T, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. |journal=DNA Res. |volume=1 |issue= 1 |pages= 27-35 |year= 1995 |pmid= 7584026 |doi=  }}
+*{{cite journal  | vauthors=Nomura N, Miyajima N, Sazuka T |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. |journal=DNA Res. |volume=1 |issue= 1 |pages= 27–35 |year= 1995 |pmid= 7584026 |doi=10.1093/dnares/1.1.27  |display-authors=etal}}
-*{{cite journal  | author=Nomura N, Miyajima N, Sazuka T, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). |journal=DNA Res. |volume=1 |issue= 1 |pages= 47-56 |year= 1995 |pmid= 7584028 |doi=  }}
+*{{cite journal  | vauthors=Nomura N, Miyajima N, Sazuka T |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). |journal=DNA Res. |volume=1 |issue= 1 |pages= 47–56 |year= 1995 |pmid= 7584028 |doi=10.1093/dnares/1.1.47  |display-authors=etal}}
-*{{cite journal  | author=Nomura N, Nagase T, Miyajima N, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 (supplement). |journal=DNA Res. |volume=1 |issue= 5 |pages= 251-62 |year= 1995 |pmid= 7584048 |doi=  }}
+*{{cite journal  | vauthors=Ebinu JO, Bottorff DA, Chan EY |title=RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs. |journal=Science |volume=280 |issue= 5366 |pages= 1082–6 |year= 1998 |pmid= 9582122 |doi=10.1126/science.280.5366.1082  |display-authors=etal}}
-*{{cite journal  | author=Ebinu JO, Bottorff DA, Chan EY, ''et al.'' |title=RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs. |journal=Science |volume=280 |issue= 5366 |pages= 1082-6 |year= 1998 |pmid= 9582122 |doi=  }}
+*{{cite journal  | vauthors=Yntema HG, Hamel BC, Smits AP |title=Localisation of a gene for non-specific X linked mental retardation (MRX46) to Xq25-q26. |journal=J. Med. Genet. |volume=35 |issue= 10 |pages= 801–5 |year= 1999 |pmid= 9783701 |doi=10.1136/jmg.35.10.801  | pmc=1051453  |display-authors=etal}}
-*{{cite journal  | author=Manser E, Loo TH, Koh CG, ''et al.'' |title=PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. |journal=Mol. Cell |volume=1 |issue= 2 |pages= 183-92 |year= 1998 |pmid= 9659915 |doi=  }}
+*{{cite journal  | vauthors=Yoshii S, Tanaka M, Otsuki Y |title=alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase. |journal=Oncogene |volume=18 |issue= 41 |pages= 5680–90 |year= 1999 |pmid= 10523848 |doi= 10.1038/sj.onc.1202936 |display-authors=etal}}
-*{{cite journal  | author=Yntema HG, Hamel BC, Smits AP, ''et al.'' |title=Localisation of a gene for non-specific X linked mental retardation (MRX46) to Xq25-q26. |journal=J. Med. Genet. |volume=35 |issue= 10 |pages= 801-5 |year= 1999 |pmid= 9783701 |doi=  }}
+*{{cite journal  | vauthors=Brown A, Wang X, Sawai E, Cheng-Mayer C |title=Activation of the PAK-related kinase by human immunodeficiency virus type 1 Nef in primary human peripheral blood lymphocytes and macrophages leads to phosphorylation of a PIX-p95 complex. |journal=J. Virol. |volume=73 |issue= 12 |pages= 9899–907 |year= 1999 |pmid= 10559302 |doi=  | pmc=113039  }}
-*{{cite journal  | author=Yoshii S, Tanaka M, Otsuki Y, ''et al.'' |title=alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase. |journal=Oncogene |volume=18 |issue= 41 |pages= 5680-90 |year= 1999 |pmid= 10523848 |doi= 10.1038/sj.onc.1202936 }}
+*{{cite journal  | vauthors=Premont RT, Claing A, Vitale N |title=The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing. |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22373–80 |year= 2000 |pmid= 10896954 |doi=10.1074/jbc.275.29.22373  |display-authors=etal}}
-*{{cite journal  | author=Brown A, Wang X, Sawai E, Cheng-Mayer C |title=Activation of the PAK-related kinase by human immunodeficiency virus type 1 Nef in primary human peripheral blood lymphocytes and macrophages leads to phosphorylation of a PIX-p95 complex. |journal=J. Virol. |volume=73 |issue= 12 |pages= 9899-907 |year= 1999 |pmid= 10559302 |doi=  }}
+*{{cite journal  | vauthors=Kutsche K, Yntema H, Brandt A |title=Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation. |journal=Nat. Genet. |volume=26 |issue= 2 |pages= 247–50 |year= 2000 |pmid= 11017088 |doi= 10.1038/80002 |display-authors=etal}}
-*{{cite journal  | author=Premont RT, Claing A, Vitale N, ''et al.'' |title=The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing. |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22373-80 |year= 2000 |pmid= 10896954 |doi=  }}
+*{{cite journal  | vauthors=Lower KM, Gecz J |title=Characterization of ARHGEF6, a guanine nucleotide exchange factor for Rho GTPases and a candidate gene for X-linked mental retardation: mutation screening in Börjeson-Forssman-Lehmann syndrome and MRX27. |journal=Am. J. Med. Genet. |volume=100 |issue= 1 |pages= 43–8 |year= 2001 |pmid= 11337747 |doi=10.1002/ajmg.1189  }}
-*{{cite journal  | author=Kutsche K, Yntema H, Brandt A, ''et al.'' |title=Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation. |journal=Nat. Genet. |volume=26 |issue= 2 |pages= 247-50 |year= 2000 |pmid= 11017088 |doi= 10.1038/80002 }}
+*{{cite journal  | vauthors=Yoshii S, Tanaka M, Otsuki Y |title=Involvement of alpha-PAK-interacting exchange factor in the PAK1-c-Jun NH(2)-terminal kinase 1 activation and apoptosis induced by benzo[a]pyrene. |journal=Mol. Cell. Biol. |volume=21 |issue= 20 |pages= 6796–807 |year= 2001 |pmid= 11564864 |doi= 10.1128/MCB.21.20.6796-6807.2001  | pmc=99857 |display-authors=etal}}
-*{{cite journal  | author=Lower KM, Gecz J |title=Characterization of ARHGEF6, a guanine nucleotide exchange factor for Rho GTPases and a candidate gene for X-linked mental retardation: mutation screening in Börjeson-Forssman-Lehmann syndrome and MRX27. |journal=Am. J. Med. Genet. |volume=100 |issue= 1 |pages= 43-8 |year= 2001 |pmid= 11337747 |doi=  }}
+*{{cite journal  | vauthors=Vikis HG, Li W, Guan KL |title=The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding. |journal=Genes Dev. |volume=16 |issue= 7 |pages= 836–45 |year= 2002 |pmid= 11937491 |doi= 10.1101/gad.966402  | pmc=186329 }}
-*{{cite journal  | author=Yoshii S, Tanaka M, Otsuki Y, ''et al.'' |title=Involvement of alpha-PAK-interacting exchange factor in the PAK1-c-Jun NH(2)-terminal kinase 1 activation and apoptosis induced by benzo[a]pyrene. |journal=Mol. Cell. Biol. |volume=21 |issue= 20 |pages= 6796-807 |year= 2001 |pmid= 11564864 |doi= 10.1128/MCB.21.20.6796-6807.2001 }}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Vikis HG, Li W, Guan KL |title=The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding. |journal=Genes Dev. |volume=16 |issue= 7 |pages= 836-45 |year= 2002 |pmid= 11937491 |doi= 10.1101/gad.966402 }}
+*{{cite journal  | vauthors=Rosenberger G, Jantke I, Gal A, Kutsche K |title=Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling. |journal=Hum. Mol. Genet. |volume=12 |issue= 2 |pages= 155–67 |year= 2003 |pmid= 12499396 |doi=10.1093/hmg/ddg019  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Flanders JA, Feng Q, Bagrodia S |title=The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins. |journal=FEBS Lett. |volume=550 |issue= 1–3 |pages= 119–23 |year= 2003 |pmid= 12935897 |doi=10.1016/S0014-5793(03)00853-6  |display-authors=etal}}
-*{{cite journal  | author=Rosenberger G, Jantke I, Gal A, Kutsche K |title=Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling. |journal=Hum. Mol. Genet. |volume=12 |issue= 2 |pages= 155-67 |year= 2003 |pmid= 12499396 |doi=  }}
+*{{cite journal  | vauthors=Brill LM, Salomon AR, Ficarro SB |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d |display-authors=etal}}
-*{{cite journal  | author=Flanders JA, Feng Q, Bagrodia S, ''et al.'' |title=The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins. |journal=FEBS Lett. |volume=550 |issue= 1-3 |pages= 119-23 |year= 2003 |pmid= 12935897 |doi=  }}
+*{{cite journal  | vauthors=Djordjevic T, Hess J, Herkert O |title=Rac regulates thrombin-induced tissue factor expression in pulmonary artery smooth muscle cells involving the nuclear factor-kappaB pathway |journal=Antioxid. Redox Signal. |volume=6 |issue= 4 |pages= 713–20 |year= 2005 |pmid= 15242552 |doi= 10.1089/1523086041361703 |display-authors=etal}}
-*{{cite journal  | author=Brill LM, Salomon AR, Ficarro SB, ''et al.'' |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763-72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
+*{{cite journal  | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446 |display-authors=etal}}
-*{{cite journal  | author=Djordjevic T, Hess J, Herkert O, ''et al.'' |title=Rac regulates thrombin-induced tissue factor expression in pulmonary artery smooth muscle cells involving the nuclear factor-kappaB pathway. |journal=Antioxid. Redox Signal. |volume=6 |issue= 4 |pages= 713-20 |year= 2005 |pmid= 15242552 |doi= 10.1089/1523086041361703 }}
+*{{cite journal  | vauthors=Jin J, Smith FD, Stark C |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |display-authors=etal}}
-*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
-*{{cite journal  | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
 }}
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ARHGEF6: Difference between revisions

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